https://hdl.handle.net/11000/7 Sat, 03 Oct 2026 14:38:38 GMT 2026-10-03T14:38:38Z https://hdl.handle.net/11000/40906 Título : Perfiles latentes de uso problemático de videojuegos en adolescentes y su asociación longitudinal con variables socioemocionales Autor : Espada, José P.; Gonzálvez Maestre, María Teresa; Amorós-Reche, Víctor; Orgilés, Mireia Resumen : El uso problemático de videojuegos en la adolescencia ha sido conceptualizado como un fenómeno heterogéneo con repercusiones en la salud mental. El presente estudio tuvo como objetivo identificar perfiles latentes de adolescentes jugadores a partir de los nueve indicadores del Trastorno de Juego por Internet y analizar su asociación longitudinal con variables socioemocionales un año después. La muestra estuvo compuesta por 1.610 adolescentes españoles (67,1% chicos; M = 13,2 años). Se realizó un Análisis de Perfiles Latentes a partir del Internet Gaming Disorder Scale – Short Form (IGDS9-SF) en la evaluación T1 y se examinaron las asociaciones con ansiedad, regulación emocional e integración/ competencia social en T2, ajustando por niveles basales. El modelo más parsimonioso identificó cuatro perfiles: sintomatología alta (5,7%), sintomatología moderada con interferencia (10,5%), sintomatología moderada sin interferencia (18,9%) y perfil normativo (64,9%). Una mayor probabilidad de pertenencia al perfil de sintomatología alta se asoció longitudinalmente con mayores dificultades de regulación emocional y menor competencia social en comparación con el perfil normativo. No se observaron diferencias significativas en ansiedad tras el ajuste por niveles previos. Estos hallazgos subrayan la heterogeneidad del uso problemático de videojuegos y la relevancia de la interferencia funcional y de la regulación emocional como dimensiones clave en su impacto socioemocional.; Problematic video game use in adolescence has been conceptualized as a heterogeneous phenomenon, with potentially different socioemotional implications over time. The present study aimed to identify latent profiles of adolescent video game players based on the nine criteria of Internet Gaming Disorder (IGD) and to examine their longitudinal associations with socioemotional outcomes one year later. The sample comprised 1,610 Spanish adolescents (67.1% boys; M = 13.2 years). A Latent Profile Analysis (LPA) was conducted using the Internet Gaming Disorder Scale – Short Form (IGDS9-SF) at the Time 1 measure. Longitudinal associations with anxiety symptoms, emotion regulation difficulties, and social integration/competence at Time 2 were examined, adjusting for baseline levels, age, and gender. The most parsimonious model identified four profiles: high symptomatology (5.7%), moderate symptomatology with functional interference (10.5%), moderate symptomatology without interference (18.9%), and a normative profile (64.9%). A higher probability of belonging to the high-symptom profile was longitudinally associated with greater emotion regulation difficulties and lower social competence compared to the normative profile. No significant longitudinal differences were observed between profiles in anxiety after controlling for baseline levels. These findings highlight the heterogeneity of problematic video game use in adolescence and underscore the relevance of functional impairment and emotion regulation as key dimensions for understanding its socioemotional impact over time. Thu, 01 Oct 2026 13:22:28 GMT https://hdl.handle.net/11000/40906 2026-10-01T13:22:28Z https://hdl.handle.net/11000/40904 Título : Lipschitz upper semicontinuity of linear inequality systems under full perturbations Autor : Camacho Moro, Jesús; Cánovas Cánovas, María Josefa; Gfrerer, Helmut; Parra López, Juan Resumen : The present paper is focused on the computation of the Lipschitz upper semicontinuity modulus of the feasible set mapping in the context of fully perturbed linear inequality systems, i.e. where all coefficients are allowed to be perturbed. The direct antecedent comes from the framework of right-hand side (RHS, for short) perturbations. The difference between both parametric contexts, full versus RHS perturbations, is emphasized. In particular, the polyhedral structure of the graph of the feasible set mapping in the latter framework enables us to apply classical results as those of Hoffman [On approximate solutions of systems of linear inequalities. J Res Natl Bur Stand. 1952;49:263–265] and Robinson [Some continuity properties of polyhedral multifunctions. Math Progr Study. 1981;14:206–214]. In contrast, the graph of the feasible set mapping under full perturbations is no longer polyhedral (not even convex). This fact requires ad hoc techniques to analyse the Lipschitz upper semicontinuity property and its corresponding modulus. Thu, 01 Oct 2026 09:28:06 GMT https://hdl.handle.net/11000/40904 2026-10-01T09:28:06Z https://hdl.handle.net/11000/40903 Título : Lipschitz upper semicontinuity in linear optimization via local directional convexity Autor : Camacho Moro, Jesús; Cánovas Cánovas, María Josefa; Parra López, Juan Resumen : This work is focussed on computing the Lipschitz upper semicontinuity modulus of the argmin mapping for canonically perturbed linear programs. The immediate antecedent can be traced out from Camacho J et al. [2022. From calmness to Hoffman constants for linear semi-infinite inequality systems. Available from: https://arxiv.org/pdf/2107.10000v2.pdf], devoted to the feasible set mapping. The aimed modulus is expressed in terms of a finite amount of calmness moduli, previously studied in the literature. Despite the parallelism in the results, the methodology followed in the current paper differs notably from Camacho J et al. [2022] as far as the graph of the argmin mapping is not convex; specifically, a new technique based on a certain type of local directional convexity is developed. Thu, 01 Oct 2026 09:26:03 GMT https://hdl.handle.net/11000/40903 2026-10-01T09:26:03Z https://hdl.handle.net/11000/40883 Título : Consecutive intrabronchial administration of Wharton’s jelly-derived mesenchymal stromal cells in ECMO-supported pediatric patients with end-stage interstitial lung disease: a safety and feasibility study (CIBA method) Autor : Dominguez-Pinilla, Nerea; González-Granado, Luis Ignacio; Gonzaga, Aitor; López Diaz, María; Castellano Yáñez, Cecilia; Aymerich, Clara; Freire, Xabier; Ordoñez, Olga; Gimeno Diaz de Atauri, Álvaro; Albi Rodríguez, María Salomé; Martínez López, Elisa; Iñiguez, Rodrigo; Serrano Garrote, Olga; Castro Frontiñán, Almudena; Andreu, Etelvina; Gutiérrez-Vílchez, Ana Mª; Anton-Bonete, Marga; Martínez-Navarrete, Gema; Castillo-Flores, Nerea; Prat-Vidal, Cristina; Blanco, Margarita; Morante Valverde, Rocío; Fernández, Eduardo; Querol, Sergi; Hernández-Blasco, Luis Manuel; Belda-Hofheinz, Sylvia; Soria, Bernat Resumen : Background: Patients ineligible for lung transplant with end-stage Interstitial Lung Disease (ILD) on Extra-Corporeal Membrane Oxygenation (ECMO) face an appalling prognosis with limited therapeutic options. Due to the beneficial effect of Mesenchymal Stromal Cells (MSC) on inflammatory, immunological and infectious diseases, cell therapy has been proposed as an option, but administration is hampered by the ECMO. Methods: Cryopreserved Wharton-jelly derived MSC (WJ-MSC) were conveniently diluted and directly applied consecutively on each lobule (5,1 ml = 107 cells) at a continuous slow rate infused over one hour via flexible bronchoscopy (Consecutive IntraBronchial Administration method, CIBA method). Results: Intrabronchial administration of MSC to a patient on ECMO was well tolerated by the patient even though it did not reverse the patient’s ILD. This manuscript presents preliminary evidence from ongoing clinical trials program on Cell Therapy of Inflammatory, Immune and Infectious Diseases and, to our knowledge, is the first report of intrabronchial administration of MSC in a paediatric ECMO patient with ILD. Even more, MSC administered by this method do not reach the systemic circulation and do get blocked on ECMO membrane. Conclusions: Direct intrabronchial administration of MSC in a patient on ECMO is feasible and safe, and may be a new avenue to be assayed in ECMO patients with inflammatory, immunological and infectious diseases of the lung. Tue, 29 Sep 2026 17:39:56 GMT https://hdl.handle.net/11000/40883 2026-09-29T17:39:56Z https://hdl.handle.net/11000/40882 Título : Tuning the Nonlinear Optical Properties of MoS2 by Interfacing with Bay- or Imide-Substituted Perylene Diimides Autor : Nikoli, Eleni; Canton-Vitoria, Ruben; Skentzos, Georgios; Pramatioti, Efrosyni; Zink-Lorre, Nathalie; Gutiérrez-Vílchez, Ana Mª; Fernández-Lázaro, Fernando; Arenal, Raul; Couris, Stelios; Tagmatarchis, Nikos Resumen : We have investigated the tuning of nonlinear optical (NLO) properties in semiconducting MoS2 nanosheets through covalent functionalization with bay- or imide-substituted perylene diimide (PDI) derivatives. Five MoS2−PDI hybrid nanomaterials 1a−5a were synthesized by attaching PDI variants featuring azobenzene or other substituents, characterized via Raman, IR, TGA, STEM-EDS, ultraviolet−visible (UV−vis), photoluminescence, and electrochemical analyses, and evaluated for NLO response under nanosecond (4 ns, 1064/532 nm) and femtosecond (70 fs, 800/400 nm) laser excitations. The hybrids exhibit enhanced and tunable NLO-absorptive (switching from saturable to reverse-saturable absorption with intensity) and NLO-refractive (self-focusing) responses compared to exfoliated MoS2, with 1a and 2a (azobenzene-substituted PDIs) showing the strongest effects due to efficient electron-transfer and -resonant excitations. Hybrids demonstrate superior NLO susceptibility (χ3) values, particularly under resonant 532 nm excitation, with Im{χ3} values of up to −514.7 ± 57.4 × 10−13 esu·mL/mg for 2a at low intensities, attributed to Pauli blocking, defect states, and two-photon processes. Hybrids having bay-substituted PDIs grafted on MoS2 enhance conjugation and performance over imide variants, enabling applications in optical-limiting, mode-locking, and photonic devices. Threshold intensities for NLA switching (150−250 MW/cm2) exceed those of MoS2, highlighting the stability for high-power uses. The developed hybrid materials advance two-dimensional transition-metal dichalcogenide-based optoelectronics by overcoming light−matter interaction limits through molecular antenna effects from PDIs. The study underscores the substituent position and azobenzene integration as levers for NLO optimization in hybrid nanoarchitectures. Tue, 29 Sep 2026 16:58:22 GMT https://hdl.handle.net/11000/40882 2026-09-29T16:58:22Z https://hdl.handle.net/11000/40880 Título : Functionalization tuning of the nonlinear optical response of perylene diimide derivativatives Autor : Skentzos, George; Pramatioti, Efrosyni; Zink-Lorre, Nathalie; Gutiérrez-Vílchez, Ana Mª; Nikoli, Eleni; Canton-Vitoria, Ruben; Fernández-Lázaro, Fernando; Couris, Stelios Resumen : The synthesis and characterization of perylene diimide (PDI) derivatives functionalized by electron donating groups at their bay and imide positions have been reported. Five different PDI derivatives were synthesized and their linear optical and third-order non-linear optical (NLO) properties were studied. The NLO measurements of the synthesized PDI derivatives were conducted under nanosecond (ns) and femtosecond (fs) laser excitation conditions, using the Z-scan technique employing 4 ns, 1064/532 nm and 70 fs, 800/400 nm laser pulses. A noticeable tuning of the NLO character between the synthesized PDI derivatives was observed, revealing the importance of the functionalization of the PDI core by the anchored electron donating units. The largest NLO value was achieved by the incorporation of p-aminoazobenzene at the PDI bay position. The experimental NLO findings and trends were further corroborated with theoretical computations of UV-Vis spectra and NLO response, performed using density functional theory (DFT). It was found that both experiments and simulations satisfactorily convey changes in the NLO response between the studied PDI derivatives. The mechanism that could lead to an efficient tuning of the PDIs’ NLO response, is associated with the modification of their electronic character resulting by the proper PDI core functionalization. Tue, 29 Sep 2026 16:41:37 GMT https://hdl.handle.net/11000/40880 2026-09-29T16:41:37Z https://hdl.handle.net/11000/40878 Título : Zinc Phthalocyanine N-Linked to Pyrroloperylenediimide Dyad: Significance of N-Connectivity in Modulating Photodynamics Toward Prolonging the Lifetime of Charge Separation Autor : Ileperuma, Chamari V.; Garcés-Garcés, Jose; Gutiérrez-Vílchez, Ana Mª; Sastre-Santos, Ángela; Fernández-Lázaro, Fernando; D'Souza, Francis Resumen : A zinc phthalocyanine–pyrroloperylenediimide dyad connected through a nitrogen heteroatom (PDI-N-ZnPc) has been newly synthesized and characterized. Solvent-polarity-dependent singlet–singlet energy transfer and electron-transfer quenching were envisioned from absorption and steady-state fluorescence studies. Electrochemical and spectroelectrochemical studies enabled the assessment of the redox potentials of the donor and acceptor entities, as well as the spectral characterization of the one-electron oxidation and reduction products. Density functional theory (DFT) studies were performed to investigate the geometry and electronic structure, as well as the role of N-connectivity in determining the relative orientation of the entities. Further, time-dependent DFT studies helped establish the different excited states responsible for promoting charge separation. An energy diagram was subsequently established to visualize different photophysical events. Finally, femtosecond transient absorption spectral studies were performed in both nonpolar and polar solvents to observe energy- and electron-transfer events. The kinetic data were subsequently analyzed using global and target analyses. The persistence of the charge-separated state in the present dyad, compared with earlier reported ZnPc–PDI dyads featuring carbon–carbon connectivity, was the primary outcome of the present study, highlighting the role of heteroatom linkage in regulating electron-transfer dynamics in donor–acceptor conjugates. Tue, 29 Sep 2026 16:13:07 GMT https://hdl.handle.net/11000/40878 2026-09-29T16:13:07Z https://hdl.handle.net/11000/40877 Título : Occurrence of excited state charge separation in a N-doped graphene–perylenediimide hybrid formed via ‘click’ chemistry Autor : Gobeze, Habtom B.; Arellano, Luis M.; Gutiérrez-Vílchez, Ana Mª; Gómez-Escalonilla, María J.; Sastre-Santos, Ángela; Fernández-Lázaro, Fernando; Langa, Fernando; D'Souza, Francis Resumen : Hetero-atom doped graphene is a two-dimensional material with a band gap, needed to build optoelectronic devices. However, research progress in this area has been sluggish due to synthetic challenges to build energy harvesting materials, especially donor–acceptor type hybrids. In the present study, using click chemistry, we have successfully synthesized a donor–acceptor hybrid comprised of Ndoped graphene and perylenediimide (PDI), a well-known electron-accepting photosensitizer. The TGA and XPS results revealed the attachment of the PDI moiety in the hybrid. Ground and excited state interactions were monitored by a variety of spectral and electrochemical techniques. Finally, the ability of the present donor–acceptor hybrid to undergo photoinduced charge separation from singlet excited PDI was systematically probed using femtosecond transient spectral techniques. Evidence of charge separation was possible to achieve from comparison of transient and spectroelectrochemical results. These results suggest the potential use of covalently functionalized, substitutional N-doped graphene as a functional material for building optoelectronic devices. Tue, 29 Sep 2026 15:46:58 GMT https://hdl.handle.net/11000/40877 2026-09-29T15:46:58Z https://hdl.handle.net/11000/40854 Título : La comedia televisiva Autor : Gómez Morales, Beatriz Maria; Hidalgo Marí, Tatiana; Ferrer Ceresola, Rosa Tue, 29 Sep 2026 11:16:11 GMT https://hdl.handle.net/11000/40854 2026-09-29T11:16:11Z https://hdl.handle.net/11000/40851 Título : A zinc phthalocyanine–benzoperylenetriimide conjugate for solvent dependent ultrafast energy vs. electron transfer Autor : Navarro-Pérez, Valeria; Gutiérrez-Vílchez, Ana Mª; Ortiz, Javier; Sastre-Santos, Ángela; Fernández-Lázaro, Fernando; Seetharaman, Sairaman; Duffy, M. J.; Karr, Paul A.; D’Souza, Francis Resumen : A novel zinc phthalocyanine–benzoperylenetriimide conjugate has been synthesized and its ability to undergo ultrafast energy and electron transfer as a function of solvent polarity has been demonstrated using the femtosecond transient absorption (fs-TA) technique operating at a femto- to nanosecond time scale. Mon, 28 Sep 2026 18:29:17 GMT https://hdl.handle.net/11000/40851 2026-09-28T18:29:17Z