https://hdl.handle.net/11000/7 2026-07-05T13:03:38Z https://hdl.handle.net/11000/40160 Título : La sostenibilidad y los ods desde el área de organización de empresas. Una propuesta de metodología docente para escalar modelos de negocio sostenibles. Autor : Sanchis Palacio, Joan Ramon; Campos Climent, Vanessa; Melian Navarro, Amparo; Ejarque Catalá, Ana Teresa 2026-07-03T10:32:43Z https://hdl.handle.net/11000/40159 Título : Las Comunidades de Regantes: infraestructura y organización. Autor : Melián Navarro, María Amparo 2026-07-03T10:31:49Z https://hdl.handle.net/11000/40158 Título : Propuesta de mejoras y su valoración. Autor : Melían Navarro, María Amparo; Ruiz Canales, Antonio 2026-07-03T10:31:07Z https://hdl.handle.net/11000/40157 Título : Safety of Dupilumab Therapy for Atopic Dermatitis during Pregnancy: A Systematic Review and Meta-analysis Autor : Sánchez-García, Verónica; de Miguel Balsa, Eva; Ramos Rincón, José Manuel; Belinchón-Romero, Isabel Resumen : Atopic dermatitis (AD) is the most common skin condition among pregnant women. However, there is limited information on the safety of biologicals during pregnancy. A systematic review and meta-analysis was conducted following the PRISMA guidelines to evaluate the effects of exposure to biologicals during pregnancy and/or preconception in women with AD, and to estimate the pooled prevalence of spontaneous abortions and congenital malformations in their newborns. MEDLINE, Embase, Scopus, and Web of Science to 31 May 2024 were searched to identify randomized controlled trials and non-randomized studies. To test the robustness of our findings, sensitivity analyses were performed. Fifteen observational studies involving 115 pregnant women with a mean age of 33.46 years (standard deviation [SD] 3.02 were included). All studies evaluated dupilumab. The mean duration of exposure to dupilumab during pregnancy was 27.52 weeks (SD 11.16). The weighted prevalence of spontaneous abortions was 18.9% (95% confidence interval 5.3 to 38.2). There were no reports of congenital malformations. The sensitivity analyses showed no significant differences in weighted prevalences. In conclusion, the current scientific evidence suggests that dupilumab is probably safe during pregnancy and preconception in women with AD, with no significant increase in the risk of miscarriage or congenital malformations compared to the general population. However, the results of this review are inconclusive due to the limited number of large, well-designed clinical studies. 2026-07-03T10:28:46Z https://hdl.handle.net/11000/40156 Título : Comparative analysis of patient and family satisfaction in Spanish Intensive Care Units: A cross-sectional study of the impact of diagnosis Autor : de Miguel Balsa, Eva; Rios-Albert, Esther; Quevedo-Sánchez, Beatriz; Jorda- Miñana, Angela; Portillo-Requena, Cristina; Perez-Quesada, Sonia; Alfaro-Garcia, Elena; Alcalá-López, Adoración Resumen : Analysing relatives and patients experiences and satisfaction can highlight areas for improving Intensive Care Units (ICUs) care. Patients and families may differ about satisfaction and experience, depending on the diagnosis and procedures. We aimed to compare the experience and satisfaction of patients according to diagnosis, severity, and the procedures received, and also between relatives and patients. Methods: Prospective analysis of voluntary responses to the FS (Family Satisfaction)- ICU 24 R questionnaire from surviving ICU patients and their relatives (January-April 2023) in four Spanish hospitals, according to diagnostic groups. Responses were scored on a Likert scale (0: worst score; 100: best score), and means and standard deviations were compared. Results: 185 responses were analysed, mostly acute cardiac pathology patients (91, 50.83%), followed by septic shock patients (22.9%). Patients rated the team performance higher than their relatives (98.79 5.37 vs 89.68 18.43; p < 0.0001), also symptom management such as pain (95.62 9.52 vs 89.64 17.24; p = 0.0001, and dyspnoea (94.23 12.27 vs 88.09 17.87; p = <0.001), the information process (91.50 13.43 vs 83.17 21.00; p < 0.001), and decision-making (80.38 13.60 vs 65.84 23.60; p < 0.001). Patients found visits to be scarce (43.75 20.79), although their families were satisfied with their involvement in care (85.49 19.64). Patients with sepsis and septic shock rated pain management the lowest compared to other diagnostic groups (sepsis/septic shock 89.58 12.5 vs 98.61 5.89; p < 0.001). Conclusions: Open visiting policies and enhancing the protocols for conscious sedation/analgesia in invasive procedures are opportunities to improve the satisfaction and experience of ICU patients and their families. 2026-07-03T10:23:51Z https://hdl.handle.net/11000/40155 Título : Screening for Human T-Cell Lymphotropic Virus (HTLV) in Pregnant Women in the Peruvian Amazon and Systematic Review with Meta-Analysis of HTLV Infection in Peru Autor : Ramos Rincón, José Manuel; Ortiz-Martínez, Sonia; Vásquez Chasnamote, María Esteyner; de Miguel Balsa, Eva; Gamboa-Paredes, Olga-Nohelia; Talledo, Michael ; López-Campana, Giovanni; Celis Salinas, Juan Carlos; Prieto-Pérez, Laura; Górgolas-Hernández, Miguel; Casapía-Morales, Martin Resumen : Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. The infection is endemic in some areas of Peru, but its prevalence in the Peruvian Amazon is not well established. We aimed to assess the seroprevalence of HTLV-1 infection in pregnant women in the Peruvian Amazon. Moreover, we performed a systematic literature review and meta-analysis of the seroprevalence of HTLV infection in Peru. (2)Methods. This is a prospective cross-sectional study involving pregnant women attending health centers in the city of Iquitos, Peru, in May and June 2019. The presence of antibodies against HTLV-1was assessed using ELISA(HTLV I + II ELISArecombinant v.4.0,Wiener lab, Rosario, Argentina). Positive caseswere confirmed byWestern Blot andHTLV-1 proviral load. (3)Results. The study included 300 pregnant women with a mean age of 26 years (standard deviation [SD] 6.4). Five patients were diagnosed with HTLV-1 infection (prevalence 1.7%, 95% confidence interval (CI) 0.7% to 3.8%). Pregnant women with HTLV-1 infection were discretely younger (mean age 22.6 [SD 22.6] vs. 26.8 [SD 6.3]; p = 0.128). None of the five women had been transfused, and all were asymptomatic. Two (40%) also had a positive serology for Strongyloides, but larvae were not detected in any of the parasitological stool studies. The systematic review component identified 40 studies, which showed that the prevalence of HTLV infection in the general population was 2.9% (95% CI 1.2% to 5.3%) and in women of childbearing age, 2.5% (95% CI 1.2% to 4.0%). (4) Conclusion. The prevalence of HTLV-1 in the Peruvian Amazon basin is about 1.7%, indicating an endemic presence. Screening for HTLV-1 in prenatal care is warranted. 2026-07-03T10:22:33Z https://hdl.handle.net/11000/40154 Título : Mineral and metal(loid)s content in canned tuna available in the Spanish market Autor : Jiménez-Redondo, Nuria; Casanova-Martínez, Isabel; Sendra, Esther; Cano-Lamadrid, Marina; Signes-Pastor, Antonio J. Resumen : Global fish consumption has increased in recent decades, and tuna is among the most popular and widely consumed species worldwide, although demand varies by region. However, tuna, including canned tuna, may contain metal(loid)s such as Hg, As, and Cd, which can pose health risks if intake exceeds established safety limits and recommended intake. This study aimed to evaluate macroelements, microelements and metal(loid)s concentrations in all available private-label (store-brand: 58 types x 2 production batches) canned tuna products commercialized in the Spanish market at the time of purchase from supermarkets in the Vega Baja del Segura region (Alicante, Spain). All available canned tuna types were analyzed, and a novel aspect was correlating element content with FAO fishing area, tuna species, and covering liquid in recently purchased samples. As and Cd levels were highest in tuna from FAO areas 51 and 34, respectively. Significant differences by species were observed only for K, Fe, Cu and Cd. Tuna in brine generally had higher macro- and microelement levels, while tomato sauce samples showed the highest Cd content. The results suggest that the mineral and metal (loid) content in canned tuna is mainly influenced by the fishing zone and the covering liquid, while the species plays a less important role. In line with these results, which highlight the importance of origin and processing in the nutritional and toxicological characterization of canned tuna products. Our findings suggest that preservation techniques aimed at minimizing metal transfer during processing should be considered, particularly through the optimization of covering liquids, especially for products originating from areas where higher concentrations were detected. 2026-07-01T12:27:37Z https://hdl.handle.net/11000/40153 Título : Evaluating Sustainable Feed Alternatives in Sparus aurata: How Alternative Proteins and Oils Maintain EPA+DHA Content and Improve Human Health Lipid Indices Autor : Sendra, Esther; Casanova-Martínez, Isabel; Rodríguez-Estrada, Marcos; Calduch-Giner, Josep Àlvar; Pérez-Sánchez, Jaume; Cano-Lamadrid, Marina Resumen : This study evaluated the effects of alternative feed formulations on the proximate composition and lipid quality of gilthead sea bream (Sparus aurata) in a long-term feeding trial (May 2022–September 2023). Three isoenergetic and isoproteic diets were tested in replicate tanks: a fishmeal-based control (CTRL), a processed animal protein–based diet (PAP), and a diet including insect meal and microalgae oil (ALT). Diet pellet sizes were adapted to the fishes’ developmental stage. Proximate composition and fatty acid profiles were assessed in feed and in fish fillets, with 20 fish analyzed per dietary treatment. The human health lipid indices of the fillets were calculated. Virtual diets were reconstructed to estimate theoretical fatty acid intake across growth, based on feed composition and consumption. Partial least squares discriminant analysis (PLS-DA) revealed distinct clustering by diet. Fillets from all diets met European Food Safety Authority criteria for being high in omega-3 fatty acids, with some variation in EPA and DHA concentrations among formulations. The ALT diet showed a 15% higher EPA+DHA content and the greatest fish lipid quality (FLQ) values, even having the lowest polyunsaturated fatty acids (PUFA) intake from feed, partly due to its elevated lauric acid (C12:0) content, which may contribute to rapid energy mobilization and omega-3 preservation. PAP-fed fish showed the most balanced PUFA/SFA and n6/n3 ratios. These findings demonstrate the viability of sustainable feed alternatives for maintaining nutritional quality in gilthead sea bream, supporting aquaculture sustainability without compromising nutritional value. 2026-07-01T12:27:01Z https://hdl.handle.net/11000/40152 Título : Metabolic and microbial stability of protein-fortified fermented dairy drinks: Effect of base and storage Autor : Rodríguez-Soriano, Marta; Solivella-Poveda, Ana M.; Ropero, Ana B.; Beltrá, Marta; Cano-Lamadrid, Marina; Sendra, Esther Resumen : Aging, particularly in the elderly, is marked by physiological changes that alter protein requirements and utilization, while higher protein intake helps maintain nutritional status and physical function. Fermented dairy products improve protein digestibility and calcium bioavailability, offering benefits for the elderly. Whey protein is a suitable fortifier due to its solubility, digestibility, and acceptance. For these reasons, this study aimed to formulate and analyse whey protein–fortified fermented dairy drinks suitable for home preparation and acceptable to elderly consumers in terms of nutritional, functional, and sensory properties. To facilitate self-care or caregiver-assisted intake, the drinks were designed to be prepared in advance and stored for consumption throughout the day. Changes in sensory attributes, microbial load, physicochemical properties (pH and color), organic acids, sugars, and free amino acids (FAA) were evaluated. Regarding sensory quality, all formulations were free of off-flavors, and notable differences in their profiles allowed for adaptation to different preferences. Microbial counts remained high (>8 log CFU g⁻¹) throughout storage, with quark and kefir-drinks showing the highest stability. The addition of whey protein decreased lightness and increased a* and b*, whereas storage at 24h20C maximized kefir acidification. Lactic acid was the predominant organic acid, and lactose and glucose levels decreased over time due to microbial activity. Finally, storage at 24h20C led to enhanced proteolytic activity; notably, kefir significantly doubled their essential FAA content. Overall, all formulations were shelf- stable under the tested conditions. 2026-07-01T12:24:14Z https://hdl.handle.net/11000/40151 Título : Derecho de los tratados [Reseña de libro] Autor : Cresppo Navarro, Elena 2026-07-01T10:26:24Z