https://hdl.handle.net/11000/6 2026-07-21T17:58:06Z 2026-07-21T17:58:06Z Gómez Bellvís, Ana Belén https://hdl.handle.net/11000/40277 2026-07-21T13:58:52Z 2026-07-21T13:58:52Z

Título : Los efectos de la sanción penal desde los datos científicos Autor : Gómez Bellvís, Ana Belén

2026-07-21T13:58:52Z Ni, Jiaqi Nishi, Stephanie K. BABIO SÁNCHEZ, NANCY Belzer, Clara Vioque, Jesús Corella, Dolores Hernando Redondo, Javier Vidal, Josep Moreno-Indias, Isabel Compañ Gabucio, Laura M Coltell, Oscar Fitó, Montse Toledo, Estefanía Wang, Dong D. Tinahones, Francisco J https://hdl.handle.net/11000/40256 2026-07-21T12:14:22Z 2026-07-21T12:14:09Z

Título : Total and different types of olive oil consumption, gut microbiota, and cognitive function changes in older adults Autor : Ni, Jiaqi; Nishi, Stephanie K.; BABIO SÁNCHEZ, NANCY; Belzer, Clara; Vioque, Jesús; Corella, Dolores; Hernando Redondo, Javier; Vidal, Josep; Moreno-Indias, Isabel; Compañ Gabucio, Laura M; Coltell, Oscar; Fitó, Montse; Toledo, Estefanía; Wang, Dong D.; Tinahones, Francisco J Resumen : Background: Over the past decade, emerging evidence has shed light on the role of the gut microbiota in the interface between diet and brain health. Olive oil, particularly virgin olive oil, a key component and major fat source in the Mediterranean diet, has exhibited widespread healthful benefits, including improvements in gut microbiota and cognitive health. Despite insights from preclinical studies into the relationship between virgin olive oil consumption, gut microbiota, and cognitive function, human research in this area remains limited. Therefore, our study aims to investigate the interplay between total olive oil consumption and its subtypes, gut microbiota, and changes in cognitive function in older adults who were cognitively healthy at baseline but at high risk of cognitive decline. Methods: In this prospective cohort study, we assessed a total of 656 participants aged 55 to 75y (mean age 65.0 ± 4.9y, 47.9% women) with overweight/obesity and metabolic syndrome who provided stool samples and completed a validated semi-quantitative food frequency questionnaire at baseline and a comprehensive battery of neuropsychological tests at baseline and at a 2-y follow-up. Results: Results from the multivariable linear regression models showed that higher consumption of virgin olive oil was associated with improved cognitive function over a 2-y follow-up, and a more diverse gut microbiota overall structure at baseline. Conversely, increased consumption of common olive oil is linked to lower alpha diversity of the microbial communities, and accelerated cognitive decline. Mediation analysis suggests that gut microbiota and particularly the Adlercreutzia, may serve as a mediator taxon in the association between virgin olive oil consumption and positive changes in general cognitive function. Conclusions: Higher consumption of virgin olive oil was associated with cognitive preservation, possibly mediated by favorable alterations in gut microbiota composition. Our study provides novel insights into the complex interplay between different types of olive oil consumption, gut microbiota, and changes in cognitive function. These findings underscore the potential of microbiota-targeted dietary strategies to promote cognitive health in aging populations, though further high-quality and clinical cohort studies are required. Video Abstract.

2026-07-21T12:14:09Z Vázquez-Lorente, Héctor Ni, Jiaqi Paz Graniel, Indira Toledo, Estefanía Corella, Dolores Castañer, Olga Martínez, J. Alfredo Alonso-Gómez, Ángel Wärnberg, Julia Vioque, Jesús Romaguera, Dora López‑Miranda, José Estruch, Ramón Tinahones, Francisco J Lapetra, José https://hdl.handle.net/11000/40255 2026-07-21T11:24:48Z 2026-07-21T11:24:45Z

Título : Dietary vitamin D intake and 2-year changes in cognitive function in older adults with overweight or obesity and metabolic syndrome Autor : Vázquez-Lorente, Héctor; Ni, Jiaqi; Paz Graniel, Indira; Toledo, Estefanía; Corella, Dolores; Castañer, Olga; Martínez, J. Alfredo; Alonso-Gómez, Ángel; Wärnberg, Julia; Vioque, Jesús; Romaguera, Dora; López‑Miranda, José; Estruch, Ramón; Tinahones, Francisco J; Lapetra, José Resumen : The protective role of dietary vitamin D intake on cognitive function is of interest, but evidence remains inconsistent. We aimed to evaluate the association between dietary vitamin D intake and 2-year cognitive changes in older adults at risk of cognitive decline. This longitudinal study comprised 5454 individuals (aged 55-75 years in men and 60-75 years in women) who exhibited overweight/obesity and metabolic syndrome. Data on dietary vitamin D intake was assessed using a validated 143-item food frequency questionnaire. Cognitive function was assessed through five composite scores derived from a comprehensive battery of eight neuropsychological tests, encompassing global cognitive function, general cognitive function, attention, executive function, and language domains. Multivariable-adjusted linear regression models were fitted to examine the association between energy-adjusted cumulative average dietary vitamin D intake over time and 2-year changes in cognitive function. After adjusting for multiple covariates, energy-adjusted cumulative average dietary vitamin D intake as a continuous variable was associated with greater 2-year improvements in global cognitive function (β 1.18 × 10-2; 95% CI 0.19 × 10-2 to 2.17 × 10-2), executive function (β 1.12 × 10-2; 95% CI 0.03 × 10-2 to 2.21 × 10-2), and language (β 1.61 × 10-2; 95% CI 0.43 × 10-2 to 2.78 × 10-2). Additionally, the higher cumulative average dietary vitamin D intake quartile was associated with an increase in global cognitive function (β 7.10 × 10-2; 95% CI 0.59 × 10-2 to 13.6 × 10-2), language (β 7.07 × 10-2; 95% CI - 0.52 × 10-2 to 14.7 × 10-2), and a lower decline in attention (β 9.58 × 10-2; 95% CI 1.60 × 10-2 to 17.5 × 10-2). A higher dietary vitamin D intake was associated with modest favorable changes in cognitive function and a reduced cognitive decline over a 2-year period. These findings highlight the need for further research to explore the potential benefits of boosting dietary vitamin D intake for cognitive health in older adults.

2026-07-21T11:24:45Z Fuentes Baile, Maria García Morales, Pilar Pérez Valenciano, Elizabeth Mata Balaguer, Trinidad Menéndez Gutiérrez, Maria P. de Juan Romero, Camino Rodríguez Lescure, Alvaro Martín Orozco, Elena Mallavia, Ricardo Barberá, Victor M. Saceda, Miguel https://hdl.handle.net/11000/40234 2026-07-21T01:04:23Z 2026-07-20T07:47:24Z

Título : Insights into histone deacetylase inhibitors-induced cell death in cancer cell lines Autor : Fuentes Baile, Maria; García Morales, Pilar; Pérez Valenciano, Elizabeth; Mata Balaguer, Trinidad; Menéndez Gutiérrez, Maria P.; de Juan Romero, Camino; Rodríguez Lescure, Alvaro; Martín Orozco, Elena; Mallavia, Ricardo; Barberá, Victor M.; Saceda, Miguel Resumen : Histone deacetylase inhibitors (HDACis) induce cell death in many chemoresistant cancer models, suggesting their potential as alternative treatments for these malignancies. However, their efficacy in solid tumors remains limited. Therefore, understanding the molecular mechanisms underlying HDACi-induced cell death is essential for developing targeted activators of these pathways, enabling the selective elimination of chemoresistant cancer cells while minimizing the widespread transcriptional effects of HDACis. In this study, we investigated HDACi- induced cell death across models of different cellular origins to determine whether a universal molecular mechanism triggers this process. Our findings demonstrate that HDACi-induced cell death is TP53-independent, resistant to caspase inhibitors, and sensitive to serine protease inhibitors. This form of cell death requires intracellular calcium mobilization to induce mitochondrial depolarization. Using DNA arrays, apoptosis protein arrays, and ELISA assays, combined with siRNA-mediated gene silencing, we identified genes with a causal relationship to TSA-induced cell death. These include dual-specificity phosphatases such as DUSP3 and DUSP10; endoplasmic reticulum stress-related genes such as XBP1, MBTPS1, MBTPS2, and RPS6KA5; and other genes like BAX, AIF, EAF2, NANOS1, and CCNYL1. Our findings reveal novel potential targets for developing antineoplastic agents designed to exploit HDACi-induced cell death pathways, providing a strategy to overcome chemoresistance in cancer therapy.

2026-07-20T07:47:24Z Bonte, Sarah M Sancho, Manuel Coves, Angela Rajo-Iglesias, Eva Vague, Jose J. Boria, Vicente E. https://hdl.handle.net/11000/40210 2026-07-17T01:04:46Z 2026-07-16T14:52:45Z

Título : Study of the Multipactor Effect in Ridge Gap Waveguide Technology Autor : Bonte, Sarah M; Sancho, Manuel; Coves, Angela; Rajo-Iglesias, Eva; Vague, Jose J.; Boria, Vicente E. Resumen : Ridge gap waveguides have emerged as promising transmission lines for high-frequency applications and components (i.e. filters), due to their low-loss characteristics and compatibility with standard fabrication processes. This article investigates the limits on the power level (related to the multipactor effect) within ridge gap waveguides, focusing on understanding the distribution and propagation of electromagnetic energy along this waveguide structure. Through simulations, the dependence of power levels on various parameters, such as the ridge dimensions and its proximity to the bed of pins, is explored. Experimental results of the multipactor effect inside a manufactured prototype of a ridge gap waveguide fully validate the simulated data obtained with the available commercial software tools. The insights provided in this research will help the future design and implementation of efficient and reliable high-frequency communication and sensing systems, for space applications, utilizing the ridge gap waveguide technology.

2026-07-16T14:52:45Z Bonte, S. M. Coves, A. San-Blas, A. A. Vague, J. J. Boria, V. E. https://hdl.handle.net/11000/40209 2026-07-17T01:04:46Z 2026-07-16T14:42:59Z

Título : Experimental Validation of Corrugated Surface Profiles for Multipactor Mitigation in Gap Waveguide Technology Autor : Bonte, S. M.; Coves, A.; San-Blas, A. A.; Vague, J. J.; Boria, V. E. Resumen : This work presents the design, fabrication, and experimental validation of corrugated surface profiles to mitigate the multipactor effect in gap waveguide technology. Two representative structures – a ridge gap waveguide (RGW) section and a groove gap waveguide (GGW) bandpass filter – are investigated. Corrugations are introduced in regions of maximum electric field to disrupt electron trajectories and increase the multipactor threshold power. A comprehensive study combining full-wave electromagnetic simulations and particle tracking is carried out to evaluate their impact on RF performance and multipactor susceptibility. Different corrugation configurations are assessed to achieve an optimal trade-off between improved power-handling capability and minimal electrical degradation. Prototypes are manufactured using standard CNC milling and experimentally tested under high-power vacuum conditions. Results show a significant increase in multipactor threshold power (about 1.5–2 kW) in both RGW and GGW structures, while maintaining low insertion loss and high return loss. The good agreement between simulations and measurements confirms the effectiveness of this simple, passive, and effective solution for enhancing the power-handling capability of gap waveguide components. The main contribution of this work is the application of corrugated profiles for multipactor mitigation, along with its experimental validation using practical RGW and GGW components. Notas: Preprint

2026-07-16T14:42:59Z Martín Melero, Iñigo Gonçalves Dosantos, Juan Carlos Landete, Mercedes Sánchez Soriano, Joaquín https://hdl.handle.net/11000/40207 2026-07-17T01:04:35Z 2026-07-16T08:51:24Z

Título : Under-capacitated p-median location problem Autor : Martín Melero, Iñigo; Gonçalves Dosantos, Juan Carlos; Landete, Mercedes; Sánchez Soriano, Joaquín Resumen : In many Location Science applications, a key challenge is the fair allocation of scarce resources among clients, especially in contexts such as disaster response, transportation planning, and healthcare systems. This challenge becomes particularly critical under severe capacity shortages, where not all demand can be satisfied, an aspect that has received limited attention in the existing literature. This paper studies the joint problem of locating p facilities from a set of candidates with heterogeneous, limited capacities and allocating indivisible resources (e.g., hospital beds) among clients. We propose a generalized capacitated p-median model that integrates location decisions with a fair allocation of insufficient capacity. Fairness is defined using concepts from bankruptcy theory in cooperative game theory, which are adapted to explicitly represent capacity scarcity. Several optimization models based on bankruptcy-inspired allocation rules are introduced and their theoretical properties are analyzed. We examine how different weights in the objective function affect the trade-offs between efficiency, equity, and network costs, and we compare bankruptcy-based allocations with alternative fairness rules. Extensions to divisible resources (e.g., water) are also discussed, and computational experiments are used to assess the impact of the proposed models on location decisions. The proposed framework is well suited for strategic and tactical planning under static and deterministic settings in which total capacity is insufficient to meet demand. Relative to classical p-median formulations and existing fairness-based benchmarks, the model explicitly represents demand shortfalls through bankruptcy-based allocation rules, leading to substantially fairer allocations while preserving high capacity utilization and competitive network costs. From a managerial perspective, the approach allows decision-makers to embed equity considerations directly into the planning stage, rather than relying on ad hoc rationing after facility locations are fixed. The practical relevance of the framework is illustrated through a real-world case study on food insecurity in Todd County, South Dakota, demonstrating its effectiveness in designing fair and efficient service networks under severe capacity shortages.

2026-07-16T08:51:24Z Martínez, Ricardo Sánchez Soriano, Joaquín Llorca, Natividad https://hdl.handle.net/11000/40206 2026-07-17T01:04:34Z 2026-07-16T08:50:49Z

Título : Assessments in public procurement procedures Autor : Martínez, Ricardo; Sánchez Soriano, Joaquín; Llorca, Natividad Resumen : In this paper we study how to assess the performance of a group of individuals according to their achievements in several attributes or categories by means of a scoring system. Such an assessment is the composition of two steps. First, each individual obtains a partial score in each category (that may potentially depend on her opponents’ performance). And second, those partial scores are combined into a global assessment. The partial score in each attribute is upper bounded by an exogenous threshold or cap. Each problem is determined by four elements: a set of agents (or tenders), a set of attributes to be evaluated, a matrix of achievements that specified the score each agent has obtained in each attribute, and a vector of caps. By means of the axiomatic methodology, we identify the families of assessment functions that satisfy some natural requirements (anonymity, continuity, monotonicity, null contribution, additivity, and separability). Our findings state that these families are weighted averages of the attribute assessments. Finally, as an illustration, we analyze a public tender whose purpose was to carry out an accounts auditing of a public company. As a practical implication of our theoretical results, we show that truncation presents significant advantages with respect to other methods. Particularly, it avoids the exclusion paradox.

2026-07-16T08:50:49Z Gonçalves Dosantos, Juan Carlos Martínez, Ricardo Sánchez Soriano, Joaquín https://hdl.handle.net/11000/40205 2026-07-17T01:04:33Z 2026-07-16T08:50:13Z

Título : Revenue distribution in streaming Autor : Gonçalves Dosantos, Juan Carlos; Martínez, Ricardo; Sánchez Soriano, Joaquín Resumen : The streaming industry has experienced exponential growth over the past decade. Streaming platforms provide subscribers with unlimited access to a diverse range of services, including movies, TV shows, and music, in exchange for a subscription fee. We take an axiomatic approach to the problem of how to share the overall revenue obtained from subscription sales among services or content producers. In doing so, we provide normative justifications for several distribution rules. We formulate several axioms that convey ethical and operational principles. In the first group, we consider properties that guarantee equal and impartial treatment of services and subscribers. In the second group, we introduce requirements designed to safeguard allocation schemes from inconvenient alterations, namely, changes in the units of measurement of inputs, subscription sharing, or group decomposition. Our analysis reveals that different combinations of these axioms define two classes of rules that strike a balance between three focal schemes, each representing distinct perspectives on the egalitarian and proportional principles. To illustrate the practical implications of our theoretical model, we explore its potential application by assessing how various types of content impact the revenues of some of the most well-known Twitch streamers.

2026-07-16T08:50:13Z Gonçalves Dosantos, Juan Carlos Sánchez Soriano, Joaquín https://hdl.handle.net/11000/40204 2026-07-17T01:04:32Z 2026-07-16T08:49:30Z

Título : Apportionment when seats are allocated in lots. The D’Hondt method case and political implications Autor : Gonçalves Dosantos, Juan Carlos; Sánchez Soriano, Joaquín Resumen : The apportionment problem involves determining how to distribute a given (non-negative) integer number among a group of individuals based on their respective sizes. In electoral systems with proportional representation, this problem arises in two situations: assigning seats to constituencies, if applicable, and distributing seats to political parties within each constituency. This paper addresses the scenario where seats are grouped into lots, extending the standard apportionment problem. We propose and analyze various apportionment methods based on the D’Hondt method for this new problem. Additionally, we examine the political implications of allocating seats not individually but in groups of varying sizes.

2026-07-16T08:49:30Z