DSpace Colección :https://hdl.handle.net/11000/4412026-04-15T05:11:21Z2026-04-15T05:11:21ZDevelopmental Neurotoxicity of Chlorpyrifos: Mechanistic Information and Predictive Safety Assessment Applications.Sachana, MagdaEstevan Martínez, Carmenhttps://hdl.handle.net/11000/392542026-02-14T02:06:57Z2026-02-13T07:46:13ZTítulo : Developmental Neurotoxicity of Chlorpyrifos: Mechanistic Information and Predictive Safety Assessment Applications.
Autor : Sachana, Magda; Estevan Martínez, Carmen
Resumen : Over the last decade a considerable body of evidence has emerged indicating that chlorpyrifos (CPF) targets important processes during nervous system development causing developmental neurotoxicity. These processes include neuronal proliferation, differentiation, axonogenesis, synaptogenesis, myelination and apoptosis. This book chapter attempts to collate mechanistic information derived from in vivo and in vitro studies investigating the neurotoxic properties of CPF in developing nervous system. Furthermore, this existing mechanistic knowledge will be organized accordingly and linked to distinct adverse outcomes that CPF can cause in developing organisms such as motor, sensory and cognitive deficits. These neurodevelopmental effects vary in severity, duration and time of onset and can be reversible or can have permanent, life-long consequences. Thus, the developmental neurotoxicity induced by CPF is complex and here there will be also presented a chemical-specific predictive risk assessment approach that will encompass all the available mechanistic as well as complementary toxicokinetic information. Additionally, this book chapter will revise all the information available from several risk assessment reports performed by different international organizations regarding the neurodevelopmental effects of CPF. An analysis of the various outcomes and the differences in diverse aspects of these assessments will be provided. Finally, the implications of these evaluations across different regulatory frameworks will be also described.2026-02-13T07:46:13ZGenomic Designing of New Plum Pox Virus Resistant Plumcot [Prunus Salicina Lindl. x Prunus Armeniaca L.] Varieties Through Interspecific HybridizationNicolás Almansa, MaríaRuiz, D.Guevara, A.Cos, J.Martínez Gómez, PedroRubio, Manuelhttps://hdl.handle.net/11000/381722025-11-18T12:59:30Z2025-11-13T08:11:24ZTítulo : Genomic Designing of New Plum Pox Virus Resistant Plumcot [Prunus Salicina Lindl. x Prunus Armeniaca L.] Varieties Through Interspecific Hybridization
Autor : Nicolás Almansa, María; Ruiz, D.; Guevara, A.; Cos, J.; Martínez Gómez, Pedro; Rubio, Manuel2025-11-13T08:11:24ZNature’s contributions to people and quality of lifeALOE KARABULUT, ArmağanAvcıoğlu Çokçalışkan, BaşakBilgin, AdemBreeze, TomBukvareva, ElenaDuez, PierreFaith, Daniel PGeijzendorffer, Ilse R.Gosal, ArjanHaider, L. JamilaKretsch, ConorLozano, JorgeMeire, PatrickSauterel, Jasmin MenaMeyer, MarkusMoleón, MarcosMorales-Reyes, Zebensuiet al.https://hdl.handle.net/11000/339652024-11-25T08:48:03Z2024-11-20T11:41:34ZTítulo : Nature’s contributions to people and quality of life
Autor : ALOE KARABULUT, Armağan; Avcıoğlu Çokçalışkan, Başak; Bilgin, Adem; Breeze, Tom; Bukvareva, Elena; Duez, Pierre; Faith, Daniel P; Geijzendorffer, Ilse R.; Gosal, Arjan; Haider, L. Jamila; Kretsch, Conor; Lozano, Jorge; Meire, Patrick; Sauterel, Jasmin Mena; Meyer, Markus; Moleón, Marcos; Morales-Reyes, Zebensui; et al.2024-11-20T11:41:34ZPercepción de los ganaderos sobre la sostenibilidad de los sistemas agroganaderos tradicionales en España en un contexto de cambio globalMorales-Reyes, ZebensuiNavarro-Ríos, María JesúsMoleón, MarcosMateo-Tomás, PatriciaBlanco, G.Botella, FranciscoDonázar, José AntonioMargalida, AntoniPérez, I.Valverde, M.Sánchez-Zapata, Jose A.https://hdl.handle.net/11000/339642025-12-03T13:09:02Z2024-11-20T11:40:09ZTítulo : Percepción de los ganaderos sobre la sostenibilidad de los sistemas agroganaderos tradicionales en España en un contexto de cambio global
Autor : Morales-Reyes, Zebensui; Navarro-Ríos, María Jesús; Moleón, Marcos; Mateo-Tomás, Patricia; Blanco, G.; Botella, Francisco; Donázar, José Antonio; Margalida, Antoni; Pérez, I.; Valverde, M.; Sánchez-Zapata, Jose A.
Resumen : Los sistemas agroganaderos tradicionales están estrechamente relacionados con la conservación de la biodiversidad y la provisión de servicios ecosistémicos. El estudio de la sostenibilidad de estos sistemas es de gran interés para la conservación de los
ecosistemas naturales europeos, profundamente ligados a la presencia de actividades humanas. Nuestro objetivo fue evaluar la
percepción de los ganaderos sobre los problemas asociados a la sostenibilidad de sus explotaciones ganaderas. Para ello, se
realizaron encuestas a 255 ganaderos en régimen extensivo y semiextensivo en seis regiones agroganaderas de España. Los factores que determinan la viabilidad y sostenibilidad de las explotaciones ganaderas según los ganaderos incluyen tanto aspectos
socio-económicos (e.g. mercados) como ambientales (e.g. climatología). En general, los problemas asociados a las fuerzas de
mercado (i.e. incremento del precio del alimento del ganado y disminución del precio de venta de los productos derivados) fueron
los más destacados por los ganaderos (>45% de ganaderos del conjunto de regiones estudiadas). Resulta destacable (>20%) la
problemática asociada a eventos climatológicos extremos (e.g. sequía o temperaturas extremas), especialmente en zonas áridas
del sureste peninsular y Canarias. En áreas con presencia de grandes depredadores se detectó un conflicto entre la conservación
de la biodiversidad y la viabilidad de las explotaciones ganaderas (hasta el 71% de los ganaderos en el noroeste de España). En
un contexto de cambio global, los resultados de este estudio suponen un importante punto de partida y proporcionan evidencias
sobre los principales factores que pueden ser abordados para preservar los múltiples servicios ecosistémicos que proveen los
sistemas agroganaderos tradicionales.2024-11-20T11:40:09ZDensidad relativa y dieta del zorro (Vulpes vulpes) en tres áreas de MurciaMorales-Reyes, ZebensuiSánchez Zapata, José AntonioBotella, FranciscoMoleón, Marcoshttps://hdl.handle.net/11000/339632024-11-25T08:48:03Z2024-11-20T11:37:50ZTítulo : Densidad relativa y dieta del zorro (Vulpes vulpes) en tres áreas de Murcia
Autor : Morales-Reyes, Zebensui; Sánchez Zapata, José Antonio; Botella, Francisco; Moleón, Marcos
Resumen : En los ecosistemas mediterráneos, el zorro (Vulpes vulpes) es uno de los carroñeros
facultativos de distribución más amplia. Nuestro objetivo principal fue evaluar la densidad relativa de
zorro y su dieta en tres áreas de Murcia con diferentes comunidades de carroñeros y ungulados
silvestres. Para conocer la densidad, se realizó un recuento de excrementos a lo largo de 19 transectos.
La dieta se estimó analizando los contenidos de los excrementos recolectados en los transectos. No se
encontraron diferencias significativas en la abundancia de zorro entre las áreas estudiadas, mientras
que sí hubo diferencias en la dieta. Por ejemplo, los zorros consumieron más carroña en Sierra Espuña,
un área con elevada densidad de ungulados y con escasa presencia de buitres.2024-11-20T11:37:50ZPercepción de los ganaderos murcianos sobre los servicios ecosistémicos proporcionados por los carroñerosMorales-Reyes, ZebensuiSánchez Zapata, José AntonioBotella, FranciscoPérez, IreneValverde, Martahttps://hdl.handle.net/11000/339622024-11-25T08:48:03Z2024-11-20T11:31:09ZTítulo : Percepción de los ganaderos murcianos sobre los servicios ecosistémicos proporcionados por los carroñeros
Autor : Morales-Reyes, Zebensui; Sánchez Zapata, José Antonio; Botella, Francisco; Pérez, Irene; Valverde, Marta
Resumen : Los humanos y los carroñeros han estado estrechamente relacionados y, actualmente muchas
poblaciones de buitres dependen de los ungulados domésticos. Nuestro objetivo es evaluar cómo los
ganaderos perciben los servicios ecosistémicos proporcionados por los carroñeros. Para ello, se
realizaron encuestas a los ganaderos de la comarca del Noroeste de Murcia. Nuestros resultados
revelan que tienen una fina percepción de los carroñeros presentes en el área de estudio. La valoración
del papel de los buitres fue muy positiva, mientras que la de los carroñeros facultativos fue neutral o
negativa. Esta percepción podría tener efectos negativos sobre las estrategias de conservación de los
carroñeros obligados.2024-11-20T11:31:09ZPolyamines as an ecofriendly postharvest tool to maintain fruit qualitySerrano, MaríaZapata, Pedro J.Martínez-Romero, DomingoDiaz-Mula, Huertas MariaValero, Danielhttps://hdl.handle.net/11000/314222025-10-21T07:31:11Z2024-02-09T18:45:48ZTítulo : Polyamines as an ecofriendly postharvest tool to maintain fruit quality
Autor : Serrano, María; Zapata, Pedro J.; Martínez-Romero, Domingo; Diaz-Mula, Huertas Maria; Valero, Daniel
Resumen : Polyamines (PAs) are natural compounds involved in a wide range of plant growth and developmental process, such as cell division, dormancy breaking, germination, development of flower buds, fruit set, growth and ripening, as well as in plant responses to environmental stresses including chilling injury. This chapter will focus on the role of PAs in fruit growth and ripening, with special emphasis on the effects of pre- and postharvest PA treatment on fruit quality attributes, bioactive constituents with antioxidant activity, and tolerance of fruit to chilling injury damage. The results of this chapter provide evidence for the numerous beneficial effects of the exogenous PA treatments, both at pre- and postharvest time in fruit quality attributes including their concentration in antioxidant compounds. Taking into account that PAs are naturally occurring molecules their application as pre- or postharvest treatment could be considered as an environmentally compatible tool as they can be metabolized by fruit cells. In addition, it should be pointed out that although exogenous application of PAs enhances their endogenous levels, the concentrations remain far lower than the toxic ones. Since modern agriculture is searching for effective biological molecules with well-known metabolic effects but without toxicological effects, a possible answer may be related to PA treatments.2024-02-09T18:45:48ZAdvances in Edible CoatingsSerrano, MaríaMartínez-Romero, DomingoZapata, Pedro J.Guillén, FabiánVeracruz, ValverdeDiaz-Mula, Huertas MariaCastillo, SalvadorValero, Danielhttps://hdl.handle.net/11000/314212025-10-21T07:31:11Z2024-02-09T18:45:36ZTítulo : Advances in Edible Coatings
Autor : Serrano, María; Martínez-Romero, Domingo; Zapata, Pedro J.; Guillén, Fabián; Veracruz, Valverde; Diaz-Mula, Huertas Maria; Castillo, Salvador; Valero, Daniel2024-02-09T18:45:36ZGastroethnobotany of HalophytesRíos, SegundoObon, ConcepcionMARTINEZ-FRANCES, VANESSAVerde, A.Ariza, D.Laguna, E.https://hdl.handle.net/11000/310082025-02-19T11:48:21Z2024-02-05T08:21:03ZTítulo : Gastroethnobotany of Halophytes
Autor : Ríos, Segundo; Obon, Concepcion; MARTINEZ-FRANCES, VANESSA; Verde, A.; Ariza, D.; Laguna, E.
Resumen : The halophytes are a specialized group of plants among which there are some
representatives that have been cultivated for millenia. Domesticated or wild
lineages are also consumed as food, being chard and dates fruits a good example
of it. Other species highly appreciated and consumed locally are collected from
wild, like Crithmum, and form part of the traditional cuisine of various areas of
the planet. Within this group, some are the object of global cultivation and are
distributed by haute cuisine networks such as Salicornia, Mertensia, or Tetragonia.
Finally, there are other wild halophytes that were only consumed in
situations of extreme need such as famines. Generally, they have not been
appreciated by the populations that collect them, such as Halosarcia, Suaeda,
or Arthrocnemum. The case of Tetragonia, a species native to Australia, is very
significant. The perception of the aborigines, who did not eat it, was different
from that of the European settlers who did consume them and even sent their
seeds to Europe for domestication and cultivation as new vegetable. Currently,
the new gastronomy, sometimes based on tradition and others on experimentation
itself, has incorporated into the kitchen many news halophytes and with them has
developed numerous unpublished and novel recipes.2024-02-05T08:21:03ZLegumes for grazing and health: the case of bituminaria bituminosaPazos Navarro, MariaDabauza, MercedesCorreal, EnriqueWalker, David Johndel Río, José AOrtuño, AnaMéndez, PilarSantos, ArnoldoRíos, SegundoMARTINEZ-FRANCES, VANESSAReal, Danielhttps://hdl.handle.net/11000/309402024-05-31T08:01:08Z2024-02-01T13:10:43ZTítulo : Legumes for grazing and health: the case of bituminaria bituminosa
Autor : Pazos Navarro, Maria; Dabauza, Mercedes; Correal, Enrique; Walker, David John; del Río, José A; Ortuño, Ana; Méndez, Pilar; Santos, Arnoldo; Ríos, Segundo; MARTINEZ-FRANCES, VANESSA; Real, Daniel
Resumen : Legumes have been used for centuries for different purposes as human food (grain
legumes such as lentils, chickpeas, etc.), animal feed (pasture and forage legumes) and as
sources of secondary metabolites with health, medical or nutraceutical benefits
(pharmaceuticals, cosmetics and chemicals). Due to this relevance, some of these species
are the subject of breeding programmes for selecting hybrids with desirable traits. To aid
in these programmes, Plant Biotechnology offers multiple methods for conservation and commercial propagation of valuable plants for different objectives, such as the
pharmaceutical industry or pasture production.
Bituminaria bituminosa (L.) C.H. Stirton (syn. Psoralea bituminosa L., Fabaceae,
Psoraleeae; Stirton 1981) is a perennial legume widely distributed in the Mediterranean
Basin and Macaronesia. The plants are grazed by small herbivores, but are mainly used
for hay to feed milking goats, mostly in the Canary Islands. Moreover, B. bituminosa
plants are a source of secondary metabolites of pharmaceutical and medicinal interest,
such as furanocoumarins (FCs, psoralen and angelicin) and pterocarpans (bitucarpin A
and B). So, their possible physiological functions and pharmacological properties are
being analysed.
Our research group began to search for alternative perennial pasture legumes for
low-rainfall Mediterranean environments at the end of the 1980‘s. B. bituminosa showed
desirable traits (tolerance to cold and/or drought), that draw it as a good option. So, the
first step was to select new germplasm with different traits to increase genetic variability
for starting a breeding programme, with the most promising varieties, accessions and
natural hybrids to deliver cultivars in the minimum time. To achieve this objective,
conventional crossing between cultivars and wild accessions, and techniques for
interspecific crossing breeding were carried out, in order to obtain new hybrid lines with
a combination of desirable traits. Then, for a commercial approach, studies based on seed
production of B. bituminosa selected cultivars have to be carried out and also research on
the alternative uses of this species, based on its content of bioactive components with
pharmaceutical potential.
As a result of this breeding programme, our research group has selected several
hybrid and non-hybrid lines showing high levels of expression of, or a combination of
desirable traits such as high forage quality, tolerance to biotic or abiotic stresses, or high
contents of FCs. Therefore, the development of biotechnological tools such as
micropropagation or in vitro plant regeneration protocols allowed the possibility of
selecting somaclonal variants, obtaining pollen-derived haploid plants for optimising
plant breeding programmes, and regenerating genetically transformed plants to control
the biosynthesis of FCs. Moreover, these techniques offer attractive approaches for the
large-scale propagation and conservation of germplasm resources of these plants.
In the present chapter, we describe this species, show its potential uses and the
strategies that may be followed to carry out a traditional breeding programme in B.
bituminosa and the tools developed to assist in it.2024-02-01T13:10:43Z