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Aplicación de la Toxina Botulínica en el Manejo de la Enfermedad de Parkinson


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Título :
Aplicación de la Toxina Botulínica en el Manejo de la Enfermedad de Parkinson
Autor :
Zemzoumi, Zineb Ez
Tutor:
García Gutiérrez, María Salud
Editor :
Universidad Miguel Hernández
Departamento:
Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica
Fecha de publicación:
2024-11-14
URI :
https://hdl.handle.net/11000/36361
Resumen :
La enfermedad de Parkinson (EP) es una patología neurodegenerativa que se caracteriza por síntomas motores como temblor, rigidez y bradicinesia y una variedad de síntomas no motores como ansiedad, depresión y trastornos del sueño, afectando significativamente tanto la calidad de vida del paciente c...  Ver más
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as tremors, rigidity, and bradykinesia, as well as a variety of non-motor symptoms, including anxiety, depression, and sleep disturbances, which significantly impact the quality of life of both patients and their caregivers and families. The most common therapy for PD remains treatment with L-DOPA, which primarily targets motor symptoms. However, the effectiveness of this treatment diminishes over time, leading to fluctuations between periods of good and poor mobility. The main objective of this study is to compile current evidence on the potential of botulinum toxin (BoNT) in managing PD, exploring its ability to improve both motor and non-motor symptoms that affect patient’s daily lives. Clinical evidence was gathered on the effects of BoNT in PD through a research in databases such as Embase and MedLine. The studies analyzed indicate that BoNT is effective in reducing both motor and non-motor symptoms without presenting severe side effects when the dosage and site of administration are appropriately tailored. This study concludes that BoNT is a promising and safe therapeutic tool for the treatment of PD symptoms, particularly those that do not respond adequately to conventional treatments. However, it highlights the importance of continued research to evaluate its long-term effects and potential neuroprotective properties, which could optimize its application in the comprehensive management of PD and enable new therapeutic strategies for this complex and debilitating disease.
Palabras clave/Materias:
Enfermedad de Parkinson
toxina botulínica
síntomas motores
síntomas no motores
calidad de vida
Área de conocimiento :
CDU: Ciencias aplicadas: Medicina: Farmacología. Terapéutica. Toxicología. Radiología
Tipo de documento :
info:eu-repo/semantics/bachelorThesis
Derechos de acceso:
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Aparece en las colecciones:
TFG - Farmacia



Creative Commons La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.