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https://hdl.handle.net/11000/35484
Immunomodulatory functions of type I interferons
Título : Immunomodulatory functions of type I interferons |
Autor : González Navajas, José Manuel Lee, Jongdae David, Michael Raz, Eyal |
Editor : Nature Pub. Group |
Departamento: Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica |
Fecha de publicación: 2012-02 |
URI : https://hdl.handle.net/11000/35484 |
Resumen :
Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector cytokines of the host immune response against viral infections. However, the production of type I IFNs is also induced in response to bacterial ligands of innate immune receptors and/or bacterial infections, indicating a broader physiological role for these cytokines in host defence and homeostasis than was originally assumed. The main focus of this Review is the underappreciated immunomodulatory functions of type I IFNs in health and disease. We discuss their function in the regulation of innate and adaptive immune responses, the response to bacterial ligands, inflammasome activation, intestinal homeostasis and inflammatory and autoimmune diseases.
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Tipo de documento : info:eu-repo/semantics/article |
Derechos de acceso: info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
DOI : 10.1038/nri3133 |
Aparece en las colecciones: Artículos Farmacología, Pediatría y Química Orgánica
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La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.