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dc.contributor.authorZapater, Pedro-
dc.contributor.authorReus, Sergio-
dc.contributor.authorTello, A.-
dc.contributor.authorTorrús, Diego-
dc.contributor.authorPérez Mateo, M.-
dc.contributor.otherDepartamentos de la UMH::Agroquímica y Medio Ambientees_ES
dc.date.accessioned2025-01-29T07:55:02Z-
dc.date.available2025-01-29T07:55:02Z-
dc.date.created2002-07-15-
dc.identifier.citationJournal of Antimicrobial Chemotherapy (2002) 50, 601–606es_ES
dc.identifier.issn0305-7453-
dc.identifier.issn1460-2091-
dc.identifier.urihttps://hdl.handle.net/11000/35442-
dc.description.abstractThe study was a prospective observational trial carried out to assess the clarithromycin–digoxin interaction in elderly patients chronically taking digoxin. Digoxin concentrations were determined before and after concomitant treatment with clarithromycin. A Bayesian approach was used to calculate digoxin pharmacokinetics. In the seven patients who were studied there was a significant increase in digoxin concentration after 4–7 days of clarithromycin treatment; digoxin clearance and elimination rate constant were 56–60% lower and elimination half-life was 82% longer. The pharmacokinetic clarithromycin–digoxin interaction in the elderly may be much more frequent than has been assumed up to nowes_ES
dc.formatapplication/pdfes_ES
dc.format.extent6es_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectClarithromycines_ES
dc.subjectDigoxines_ES
dc.subjectPharmacokinetices_ES
dc.subjectInteractiones_ES
dc.subjectBayesianes_ES
dc.titleA prospective study of the clarithromycin-digoxin interaction in elderly patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1093/jac/dkf176es_ES
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