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  5. Artículos Bioquímica y Biología Molecular
Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/35238
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dc.contributor.authorCabañero, David-
dc.contributor.authorVillalba Riquelme, Eva María-
dc.contributor.authorFernández Ballester, Gregorio-
dc.contributor.authorFernández Carvajal, Asia-
dc.contributor.authorFerrer-Montiel, Antonio-
dc.contributor.otherDepartamentos de la UMH::Bioquímica y Biología Moleculares_ES
dc.date.accessioned2025-01-24T12:21:15Z-
dc.date.available2025-01-24T12:21:15Z-
dc.date.created2022-
dc.identifier.citationPharmacology&Therapeutics 240 (2022) 108297es_ES
dc.identifier.issn1879-016X-
dc.identifier.issn0163-7258-
dc.identifier.urihttps://hdl.handle.net/11000/35238-
dc.description.abstractChronicpainisamajorburdenforthesocietyandremainsmoreprevalentandsevereinfemales.Thepresenceofchronicpainislinkedtopersistentalterationsintheperipheralandthecentralnervoussystem. Oneof themaintypesofperipheralpaintransducersarethetransient receptorpotential channels (TRP),alsoknownasthermoTRPchannels,whichinterveneintheperceptionofhotandcoldexternal stimuli.Thesechannels,andespeciallyTRPV1,TRPA1andTRPM8,havebeensubjectedtoprofoundinvestigationbecauseoftheirroleasthermosensorsandalsobecauseoftheirimplicationinacuteandchronic pain.Surprisingly, theirsensitivitytoendogenoussignalinghasbeenfarlessstudied.Cumulativeevidencesuggeststhatthefunctionofthesechannelsmaybedifferentlymodulatedinmalesandfemales, inpartthroughsexualhormones,andthiscouldconstituteasignificantcontributortothesexdifferences inchronicpain.Here,wereviewtheexcitingadvancesinthermoTRPpharmacologyformalesandfemales intwoparadigmatictypesofchronicpainwithastrongperipheralcomponent:chronicmigraineand chemotherapy-inducedperipheralneuropathy(CIPN).Thepossibilitiesofperipheraldruggabilityoffered bythesechannelsandthedifferentialexploitationformenandwomenrepresentadevelopmentopportunitythatwill leadtoasignificantincrementofthearmamentariumofanalgesicmedicinesforpersonalizedchronicpaintreatment.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent18es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNociceptorses_ES
dc.subjectIonchannelses_ES
dc.subjectInflammationes_ES
dc.subjectNeuropathices_ES
dc.subjectAllodyniaes_ES
dc.subjectHyperalgesiaes_ES
dc.subjectCGRPes_ES
dc.subjectHormoneses_ES
dc.subjectMenstrualcyclees_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biologíaes_ES
dc.titleThermoTRP channels in pain sexual dimorphism: new insights for drug interventiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.pharmthera.2022.108297es_ES
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Artículos Bioquímica y Biología Molecular


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