Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/34676

pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis


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Title:
pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis
Authors:
Gonzalez-Alvarez, Isabel  
Vivancos, Verónica
Coll, Carmen  
Sánchez-Dengra, Bárbara  
Aznar, Elena  
Ruiz Picazo, Alejandro  
Bermejo, Marival
Sancenón, Félix  
Dea Ayuela, Auxiliadora  
González Álvarez, Marta
Martínez Máñez, Ramón
Editor:
MDPI
Department:
Departamentos de la UMH::Ingeniería
Issue Date:
2021-01-13
URI:
https://hdl.handle.net/11000/34676
Abstract:
Giardiasis is a parasitism produced by the protozoa Giardia intestinalis that lives as trophozoite in the small intestine (mainly in the duodenum) attached to the intestinal villus by means of billed discs. The first line treatment is metronidazole, a drug with high bioavailability, which is why to obtain therapeutic concentrations in duodenum, it is necessary to administer high doses of drug to patients with the consequent occurrence of side effects. It is necessary to developed new therapeutical approaches to achieve a local delivery of the drug. In this sense, we have developed gated mesoporous silica microparticles loaded with metronidazole and with a molecular gate pH dependent. In vitro assays demonstrated that the metronidazole release is practically insignificant at acidic pHs, but in duodenum conditions, the metronidazole delivery from the microparticles is effective enough to produce an important parasite destruction. In vivo assays indicate that this microparticulate system allows to increase the concentration of the drug in duodenum and reduce the concentration in plasma avoiding systemic effects. This system could be useful for other intestinal local treatments in order to reduce doses and increase drug availability in target tissues.
Keywords/Subjects:
mesoporous microparticles
G. intestinalis
molecular gate
targeted drug delivery
oral administration
Knowledge area:
CDU: Ciencias aplicadas: Ingeniería. Tecnología
Type of document:
info:eu-repo/semantics/article
Access rights:
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
DOI:
https://doi.org/10.3390/pharmaceutics13010094
Appears in Collections:
Artículos Ingeniería



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