Título : Hospitalización de causa respiratoria en pacientes con Fibrosis Pulmonar Idiopática. |
Autor : Pérez Díaz, Ainhoa |
Tutor: García Sevilla, Raquel Gayá García-Manso, Ignacio |
Editor : Universidad Miguel Hernández |
Departamento: Departamentos de la UMH::Medicina Clínica |
Fecha de publicación: 2024-05-01 |
URI : https://hdl.handle.net/11000/33748 |
Resumen :
Introducción: La Fibrosis Pulmonar Idiopática (FPI) es una enfermedad pulmonar
intersticial fibrosante crónica que se asocia a una caída de la función pulmonar
progresiva y a un pobre pronóstico. El curso clínico de la FPI es heterogéneo, desde
formas estables en el tiempo, a fallo respiratorio pro... Ver más
Introduction: Idiopathic Pulmonary Fibrosis (IPF) is a chronic fibrosing interstitial lung
disease associated with progressive lung function decline and poor prognosis. The
clinical course of IPF is heterogeneous, ranging from stable forms over time, to
progressive respiratory failure or the presentation of acute exacerbation (AE). The
"International Working Group Project" proposed in 2016 (1) diagnostic criteria for AE in
IPF patients and defined them as idiopathic or secondary to a trigger (viral infections,
chemotherapy, thoracic surgery, radiotherapy). Hospitalizations are very frequent in
these patients and are associated with high mortality and deterioration of quality of life,
especially when they are due to AE and require care in critical care units or mechanical
ventilation.
Objective: To analyze admissions due to respiratory causes in patients with IPF in the
two years following diagnosis.
Methods: The study included 88 patients diagnosed with IPF between 2009 and 2021 at
the Hospital General Universitario Dr. Balmis in Alicante. Data were collected and the
pneumological cause of admissions, treatment of AE and evolution of patients with IPF
were retrospectively analyzed. Results: Of the 88 patients included, 82 admissions for respiratory causes were observed
during the first 2 years of follow-up. Of these admissions, AE accounted for 43.9%,
followed by disease progression, with 31.7%. Patients who did not exacerbate had a
mean forced vital capacity (FVC) of 2414.8 ± 793.67 mL and 76.9 ± 21.4% at diagnosis,
with a mean carbon monoxide diffusing capacity (DLCO) of 51 ± 18.74%. Those who had
presented any exacerbation during the two years following diagnosis had at baseline a
mean FVC of 1971.3 ± 568.77 mL and 66.9± 19.1 %, with a mean DLCO of 38 ± 11.91%.
Statistically significant differences were found in FVC and DLCO between patients with
AE and without AE (p<0.05). For treatment of AE, corticosteroid boluses were used in
69.4% of patients versus 30.6% with corticosteroid at a dose of 1 mg/kg. A total of 17
patients died of pneumological causes, 7 of them from AE.
Conclusions: AE is the most frequent pneumological cause of admission in patients with
IPF in the 2 years following diagnosis. AE is the most frequent pneumological cause of
death in these patients.
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Palabras clave/Materias: fibrosis pulmonar idiopática exacerbación aguda ingresos hospitalarios corticoides mortalidad |
Área de conocimiento : CDU: Ciencias aplicadas: Medicina |
Tipo de documento : info:eu-repo/semantics/bachelorThesis |
Derechos de acceso: info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: TFG- Medicina
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