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dc.contributor.authorBallester, Pura-
dc.contributor.authorMartínez-Madrid, María José-
dc.contributor.authorJavaloyes, María Auxiliadora-
dc.contributor.authorBelda-Cantó, César-
dc.contributor.authorAguilar, Victor-
dc.contributor.authorInda, María del Mar-
dc.contributor.authorRichdale, Amanda-
dc.contributor.authorMuriel, Javier-
dc.contributor.authorMorales, Domingo-
dc.contributor.authorPeiró, Ana-
dc.contributor.otherDepartamentos de la UMH::Farmacología, Pediatría y Química Orgánicaes_ES
dc.date.accessioned2024-07-18T10:00:23Z-
dc.date.available2024-07-18T10:00:23Z-
dc.date.created2021-03-
dc.identifier.citationResearch in Autism Spectrum Disorders, 81, March 2021, 101715es_ES
dc.identifier.issn1750-9467-
dc.identifier.urihttps://hdl.handle.net/11000/32542-
dc.description.abstractBackground: People diagnosed with Autism Spectrum Disorder and intellectual disability (ID) usually experience sleep problems, where circadian clock and melatonin pathway genes may play a role. Method: Our aim was to analyze the influence of genetic variants PER1, ASMT, NPAS2, and MTNR1A by MassARRAY, in sleep-wake rhythms in a group of autistic adults with ID, cases (n = 83) and controls (n = 25). Sleep-wake rhythms were evaluated with ambulatory circadian monitoring. Results: In autistic cases (age 18􀀀 41years), PER1 rs6416892-GG and ASMT rs5989681-GG genotypes had a better sleep pattern according to sleep onset latency and awakenings; together with a worse sleep and/or temperature rhythm. Furthermore, diurnal temperature values were affected by NPAS2 rs1811399-CC genotype. Conclusions: Normal and abnormal sleep-wake rhythms could be related to circadian clock (PER1) and melatonin pathway (ASMT) gene variants. There is a need for further research to translate this data into clinical decisions or risk profiles.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent12es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAutism spectrum disorderes_ES
dc.subjectSleep problemses_ES
dc.subjectCircadian clock geneses_ES
dc.subjectMelatonin pathway geneses_ES
dc.subjectAmbulatory circadian monitoringes_ES
dc.subject.otherCDU: Ciencias aplicadas: Medicina: Farmacología. Terapéutica. Toxicología. Radiología-
dc.titleInterplay of circadian clock and melatonin pathway gene variants in adults with autism, intellectual disability and sleep problemses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.rasd.2020.101715es_ES
Aparece en las colecciones:
Artículos Farmacología, Pediatría y Química Orgánica


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