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https://hdl.handle.net/11000/32360
Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain
Title: Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain |
Authors: Segura, Ana Ballester, Purificación Ajo Ferrer, Raquel Inda, María del Mar Urbano, Antonio Muriel, Javier Ochando, Isabel Margarit, César Martinez, Emi Peiró, Ana |
Editor: Elsevier |
Department: Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica |
Issue Date: 2019 |
URI: https://hdl.handle.net/11000/32360 |
Abstract:
Objectives: To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards.
Subject patients/methods: The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software.
Results: A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients.
Conclusion: T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.
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Keywords/Subjects: Chronic pain Erectile dysfunction Pharmacogenetics T786C eNOS gene iPDE5 |
Knowledge area: CDU: Ciencias aplicadas: Medicina: Farmacología. Terapéutica. Toxicología. Radiología |
Type of document: info:eu-repo/semantics/article |
Access rights: info:eu-repo/semantics/openAccess |
DOI: https://doi.org/10.1016/j.gene.2019.100005 |
Appears in Collections: Artículos Farmacología, Pediatría y Química Orgánica
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