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Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain

Título :
Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain
Autor :
Segura, Ana  
Ballester, Purificación
Ajo Ferrer, Raquel  
Inda, María del Mar
Urbano, Antonio  
Muriel, Javier  
Ochando, Isabel  
Margarit, César
Martinez, Emi
Peiró, Ana  
Editor :
Elsevier
Departamento:
Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica
Fecha de publicación:
2019
URI :
https://hdl.handle.net/11000/32360
Resumen :
Objectives: To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards. Subject patients/methods: The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software. Results: A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients. Conclusion: T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.
Palabras clave/Materias:
Chronic pain
Erectile dysfunction
Pharmacogenetics
T786C
eNOS gene
iPDE5
Área de conocimiento :
CDU: Ciencias aplicadas: Medicina: Farmacología. Terapéutica. Toxicología. Radiología
Tipo de documento :
info:eu-repo/semantics/article
Derechos de acceso:
info:eu-repo/semantics/openAccess
DOI :
https://doi.org/10.1016/j.gene.2019.100005
Aparece en las colecciones:
Artículos Farmacología, Pediatría y Química Orgánica



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