Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/32357

OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients

Title:
OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients
Authors:
Muriel, Javier  
Margarit, César
Planelles, Beatriz
Serralta, María J.
Puga, Carmen
Inda, María del Mar
Cutillas, Esperanza  
Morales, Domingo  
Horga, José Francisco  
Peiró, Ana  
Editor:
Wiley
Department:
Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica
Issue Date:
2018-08
URI:
https://hdl.handle.net/11000/32357
Abstract:
Screening for opioid use disorder should be considered in chronic non-cancer pain (CNCP) patients with long-term use of opioids. The aim of our study was to assess the effectiveness of an individualized treatment plan (ITP) for prescription opioid dependence that included screening of pharmacogenetic markers. An observational prospective study was performed using prescription opioid-dependent CNCP outpatients (n = 88). Patients were divided into nonresponders, responders, or high responders according to their response to the ITP. Genotyping of OPRM1 (A118G), OPRD1 (T921C), COMT (G472A), ABCB1 (C3435T), and ARRB2 (C8622T) was performed by real-time PCR. Our ITP achieved a significant reduction of the morphine equivalent daily dose (MEDD) in 64% of responders, including 33% of high responders. Nonopioid medication or buprenorphine use was significantly higher at final versus basal visit. 118-AA OPRM1 patients required significantly lower MEDD at basal and final visits. Our ITP showed effectiveness and security in reducing MEDD in opioid-dependent patients, with good conversion to buprenorphine that was more pronounced in 118-AA OPRM1 patients.
Keywords/Subjects:
OPRM1
chronic pain
opioid
opioid use disorder
pharmacogenetics
Knowledge area:
CDU: Ciencias aplicadas: Medicina: Farmacología. Terapéutica. Toxicología. Radiología
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
DOI:
https://doi.org/10.1111/nyas.13735
Appears in Collections:
Artículos Farmacología, Pediatría y Química Orgánica



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