Title: Association of cannabinoid receptor genes (CNR1 and CNR2) polymorphisms and panic disorder |
Authors: Peiró, Ana ![](/image/ORCID.jpg) García Gutiérrez, María S. Planelles, Beatriz Femenía, Teresa Mingote, Carlos Jiménez-Treviño, Luis ![](/image/ORCID.jpg) Martínez Barrondo, Sara Garcia-Portilla, Paz ![](/image/ORCID.jpg) Saiz, Pilar A. ![](/image/ORCID.jpg) Bobes, Julio ![](/image/ORCID.jpg) Manzanares, Jorge ![](/image/ORCID.jpg) |
Editor: Routledge Taylor & Francis Group |
Department: Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica |
Issue Date: 2020-05 |
URI: https://hdl.handle.net/11000/32340 |
Abstract:
Background and objectives: Panic disorder (PD) is an anxiety disorder characterized by recurrent and unexpected panic attacks along with sudden onset of apprehension, fear or terror. The endocannabinoid system (ECS) has a role in stress recovery, regulating anxiety. The aim of this study was to analyze potential genetic alterations in key ECS targets in patients suffering from panic disorders.Design and methods: We analyzed single nucleotide polymorphisms (SNPs) of the cannabinoid receptors (CNR1; CNR2) and the endocannabinoid hydrolytic enzyme fatty acid amide hydrolase (FAAH) genes in 164 Spanish PD patients and 320 matched controls.Results: No significant differences were observed in the SNPs of the CNR2 and FAAH genes tested. However, when analyzing genotype-by-sex interaction at A592G (rs2501431) and C315T (rs2501432) in the CNR2 gene, the presence of the G-allele in males was associated with a protective haplotype. Genotyping analysis revealed that variants in CNR1 confer vulnerability to PD, with a significantly increased risk associated with the G-allele (rs12720071) and C-allele (rs806368). This finding was consistent when analyzing genotype-by-sex interaction, where females presented a greater PD risk.Conclusions: Polymorphisms at the CNR1 gene may be a risk factor for PD contributing to sex-specific dysfunction in females.
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Keywords/Subjects: CNR1 CNR2 FAAH Panic disorder panic attacks single nucleotide polymorphism |
Knowledge area: CDU: Ciencias aplicadas: Medicina: Farmacología. Terapéutica. Toxicología. Radiología |
Type of document: application/pdf |
Access rights: info:eu-repo/semantics/closedAccess |
DOI: https://doi.org/10.1080/10615806.2020.1732358 |
Appears in Collections: Artículos Farmacología, Pediatría y Química Orgánica
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