Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/32340
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dc.contributor.authorPeiró, Ana-
dc.contributor.authorGarcía Gutiérrez, María S.-
dc.contributor.authorPlanelles, Beatriz-
dc.contributor.authorFemenía, Teresa-
dc.contributor.authorMingote, Carlos-
dc.contributor.authorJiménez-Treviño, Luis-
dc.contributor.authorMartínez Barrondo, Sara-
dc.contributor.authorGarcia-Portilla, Paz-
dc.contributor.authorSaiz, Pilar A.-
dc.contributor.authorBobes, Julio-
dc.contributor.authorManzanares, Jorge-
dc.contributor.otherDepartamentos de la UMH::Farmacología, Pediatría y Química Orgánicaes_ES
dc.date.accessioned2024-06-25T11:42:20Z-
dc.date.available2024-06-25T11:42:20Z-
dc.date.created2020-05-
dc.identifier.citationAnxiety Stress and Coping. 2020 May;33(3):256-265es_ES
dc.identifier.issn1477-2205-
dc.identifier.issn1061-5806-
dc.identifier.urihttps://hdl.handle.net/11000/32340-
dc.description.abstractBackground and objectives: Panic disorder (PD) is an anxiety disorder characterized by recurrent and unexpected panic attacks along with sudden onset of apprehension, fear or terror. The endocannabinoid system (ECS) has a role in stress recovery, regulating anxiety. The aim of this study was to analyze potential genetic alterations in key ECS targets in patients suffering from panic disorders.Design and methods: We analyzed single nucleotide polymorphisms (SNPs) of the cannabinoid receptors (CNR1; CNR2) and the endocannabinoid hydrolytic enzyme fatty acid amide hydrolase (FAAH) genes in 164 Spanish PD patients and 320 matched controls.Results: No significant differences were observed in the SNPs of the CNR2 and FAAH genes tested. However, when analyzing genotype-by-sex interaction at A592G (rs2501431) and C315T (rs2501432) in the CNR2 gene, the presence of the G-allele in males was associated with a protective haplotype. Genotyping analysis revealed that variants in CNR1 confer vulnerability to PD, with a significantly increased risk associated with the G-allele (rs12720071) and C-allele (rs806368). This finding was consistent when analyzing genotype-by-sex interaction, where females presented a greater PD risk.Conclusions: Polymorphisms at the CNR1 gene may be a risk factor for PD contributing to sex-specific dysfunction in females.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent11es_ES
dc.language.isoenges_ES
dc.publisherRoutledge Taylor & Francis Groupes_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCNR1es_ES
dc.subjectCNR2es_ES
dc.subjectFAAHes_ES
dc.subjectPanic disorderes_ES
dc.subjectpanic attackses_ES
dc.subjectsingle nucleotide polymorphismes_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiologíaes_ES
dc.titleAssociation of cannabinoid receptor genes (CNR1 and CNR2) polymorphisms and panic disorderes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1080/10615806.2020.1732358es_ES
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Artículos Farmacología, Pediatría y Química Orgánica


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