Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/32235
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dc.contributor.authorRuschel Tallini, Luciana-
dc.contributor.authorManfredini, Giulia-
dc.contributor.authorRodríguez Escobar, María Lenny-
dc.contributor.authorRíos, Segundo-
dc.contributor.authorMARTINEZ-FRANCES, VANESSA-
dc.contributor.authorFERESIN, GABRIELA EGLY-
dc.contributor.authorde Souza Borges, Warley-
dc.contributor.authorBASTIDA, JAUME-
dc.contributor.authorViladomat, Francesc -
dc.contributor.authorTorras-Claveria, Laura-
dc.contributor.otherDepartamentos de la UMH::Biología Aplicadaes_ES
dc.date.accessioned2024-05-29T07:07:42Z-
dc.date.available2024-05-29T07:07:42Z-
dc.date.created2024-04-22-
dc.identifier.citationLife 2024, 14, 536es_ES
dc.identifier.issn2075-1729-
dc.identifier.urihttps://hdl.handle.net/11000/32235-
dc.description.abstractNarcissus L. is a renowned plant genus with a notable center of diversity and is primarily located in the Mediterranean region. These plants are widely recognized for their ornamental value, owing to the beauty of their flowers; nonetheless, they also hold pharmacological importance. In Europe, pharmaceutical companies usually use the bulbs of Narcissus pseudonarcissus cv. Carlton to extract galanthamine, which is one of the few medications approved by the FDA for the palliative treatment of mild-to-moderate symptoms of Alzheimer’s disease. The purpose of this study was to evaluate the potential of these plants in Alzheimer’s disease. The alkaloid extract from the leaves of different species of Narcissus was obtained by an acid-base extraction work-up -procedure. The biological potential of the samples was carried out by evaluating their ability to inhibit the enzymes acetyl- and butyrylcholinesterase (AChE and BuChE, respectively). The species N. jacetanus exhibited the best inhibition values against AChE, with IC50 values of 0.75 ± 0.03 µg·mL−1 , while N. jonquilla was the most active against BuChE, with IC50 values of 11.72 ± 1.15 µg·mL−1 .es_ES
dc.formatapplication/pdfes_ES
dc.format.extent15es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectacetylcholinesterasees_ES
dc.subjectAmaryllidaceaees_ES
dc.subjectalkaloidses_ES
dc.subjectAlzheimer’s diseasees_ES
dc.subjectbutyrylcholinesterasees_ES
dc.subjectNarcissuses_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biologíaes_ES
dc.titleThe Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spaines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3390/life14040536es_ES
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