Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31402

Sex-Differences in Pain and Opioid Use Disorder Management: A Cross-Sectional Real-World Study

Title:
Sex-Differences in Pain and Opioid Use Disorder Management: A Cross-Sectional Real-World Study
Authors:
Escorial, Mónica  
Muriel, Javier  
César, Margarit
Laura, Agulló
Domingo, Morales
Peiró, Ana  
Editor:
MDPI
Department:
Departamentos de la UMH::Medicina Clínica
Issue Date:
2022
URI:
https://hdl.handle.net/11000/31402
Abstract:
Background: It is essential to focus attention on sex-specific factors which are clinically relevant in pain management, especially with regards to opioid use disorder (OUD) risk. The aim of this study was to explore potential sex-differences in chronic non-cancer pain (CNCP) outpatients. (2) Methods: An observational cross-sectional study was conducted under CNCP outpatients with long-term prescribed opioids (n = 806), wherein 137 patients had an OUD diagnosis (cases, 64% females) and 669 did not (controls, 66% females). Socio-demographic, clinical, and pharmacological outcomes were analyzed. (3) Results: Female controls presented an older age and less intensive pain therapy but higher psychotropic prescriptions and emergency department visits compared to male controls. Meanwhile, cases demonstrated a younger age, higher work disability, double morphine equivalent daily dose, and benzodiazepine use compared with controls. Here, female cases showed an 8% greater substance use disorder (OR 2.04 [1.11-3.76]) and 24% lower tramadol use, while male cases presented a 22% higher fentanyl use (OR 2.97 [1.52-5.81]) and reported the highest number of adverse drug reactions (24%, OR 2.40 [1.12-5.16]) compared with controls. (4) Conclusions: An OUD individual risk profile was evidenced with sex-differences to take into consideration to design equal prevention programs.
Keywords/Subjects:
opioid use disorder
sex-differences
chronic non-cancer pain;
gender disparities
pain management
prevention programs
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
DOI:
https://doi.org/10.3390/biomedicines10092302
Appears in Collections:
Artículos Farmacología, Pediatría y Química Orgánica



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