Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31333
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dc.contributor.authorLópez Almela, Inmaculada-
dc.contributor.authorRomaní Pérez, Marina-
dc.contributor.authorBullich-Vilarrubias, Clara-
dc.contributor.authorBenítez-Páez, Alfonso-
dc.contributor.authorGómez Del Pulgar, Eva M.-
dc.contributor.authorFrancés, Rubén-
dc.contributor.authorLiebisch, Gerhard-
dc.contributor.authorSanz, Yolanda-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.date.accessioned2024-02-09T08:54:48Z-
dc.date.available2024-02-09T08:54:48Z-
dc.date.created2021-12-
dc.identifier.citationGut Microbes. 2021 Jan-Dec;13(1):1-20es_ES
dc.identifier.issn1949-0984-
dc.identifier.issn1949-0976-
dc.identifier.urihttps://hdl.handle.net/11000/31333-
dc.description.abstractGut microbiota represents a therapeutic target for obesity. We hypothesize that B. uniformis CECT 7771 combined with wheat bran extract (WBE), its preferred carbon source, may exert superior anti-obesity effects. We performed a 17-week intervention in diet-induced obese mice receiving either B. uniformis, WBE, or their combination to identify interactions and independent actions on metabolism and immunity. B. uniformis combined with WBE was the most effective intervention, curbing weight gain and adiposity, while exerting more modest effects separately. The combination restored insulin-dependent metabolic routes in fat and liver, although the bacterium was the primary driver for improving whole-body glucose disposal. Moreover, B. uniformis-combined with WBE caused the highest increases in butyrate and restored the proportion of induced intraepithelial lymphocytes and type-3 innate lymphoid cells in the intestinal epithelium. Thus, strengthening the first line of immune defense against unhealthy diets and associated dysbiosis in the intestine. This intervention also attenuated the altered IL22 signaling and liver inflammation. Our study shows opportunities for employing B. uniformis, combined with WBE, to aid in the treatment of obesity.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent20es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectObesityes_ES
dc.subjectdietary fiberes_ES
dc.subjectmicrobiotaes_ES
dc.subjectintraepithelial lymphocyteses_ES
dc.subjectinnate lymphoid cellses_ES
dc.titleBacteroides uniformis combined with fiber amplifies metabolic and immune benefits in obese micees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1080/19490976.2020.1865706es_ES
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Artículos Medicina Clínica


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