Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31171

Adhesion molecule Amigo2 is involved in the fasciculation process of the fasciculus retroflexus

Title:
Adhesion molecule Amigo2 is involved in the fasciculation process of the fasciculus retroflexus
Authors:
Company Devesa, Verónica
Murcia Ramón, Raquel
Andreu Cervera, Abraham
Aracil Pastor, Paula
Almagro García, Francisca de Paula
Martínez Pérez, Salvador
Echevarría, Diego
de Puelles Martínez de La Torre, Eduardo
Editor:
Wiley [Commercial Publisher]
Department:
Departamentos de la UMH::Patología y Cirugía
Instituto de Neurociencias
Departamentos de la UMH::Histología y Anatomía
Issue Date:
2022-11
URI:
https://hdl.handle.net/11000/31171
Abstract:
Background: The fasciculus retroflexus is the prominent efferent pathway from the habenular complex. Medial habenular axons form a core packet whereas lateral habenular axons course in a surrounding shell. Both groups of fibers share the same initial pathway but differ in the final segment of the tract, supposedly regulated by surface molecules. The gene Amigo2 codes for a membrane adhesion molecule with an immunoglobulin-like domain 2 and is selectively expressed in the medial habenula. We present it as a candidate for controlling the fasciculation behavior of medial habenula axons. Results: First, we studied the development of the habenular efferents in an Amigo2 lack of function mouse model. The fasciculus retroflexus showed a variable defasciculation phenotype. Gain of function experiments allowed us to generate a more condensed tract and rescued the Amigo2 knock-out phenotype. Changes in Amigo2 function did not alter the course of habenular fibers. Conclusion: We have demonstrated that Amigo2 plays a subtle role in the fasciculation of the fasciculus retroflexus
Keywords/Subjects:
Amigo2
fasciculation
fasciculus retroflexus
lateral habenula
medial habenula
Type of document:
info:eu-repo/semantics/article
Access rights:
info:eu-repo/semantics/openAccess
DOI:
https://doi.org/10.1002/dvdy.513
Appears in Collections:
Artículos Patología y Cirugía



Creative Commons ???jsp.display-item.text9???