Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31168

Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons

Title:
Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons
Authors:
Company Devesa, Verónica
Andreu Cervera, Abraham
Madrigal Verdú, María del Pilar
Andrés Bayón, Belén
Almagro García, Francisca de Paula
Chedotal, Alain
López Bendito, Guillermina
Martínez Pérez, Salvador
Echevarría Aza, Diego
Moreno Bravo, Juan Antonio
de Puelles Martínez de La Torre, Eduardo
Editor:
Frontiers Media [Commercial Publisher]
Department:
Departamentos de la UMH::Patología y Cirugía
Departamentos de la UMH::Histología y Anatomía
Instituto de Neurociencias
Issue Date:
2021-06
URI:
https://hdl.handle.net/11000/31168
Abstract:
The fasciculus retroflexus is an important fascicle that mediates reward-related behaviors and is associated with different psychiatric diseases. It is the main habenular efference and constitutes a link between forebrain regions, the midbrain, and the rostral hindbrain. The proper functional organization of habenular circuitry requires complex molecular programs to control the wiring of the habenula during development. However, the mechanisms guiding the habenular axons toward their targets remain mostly unknown. Here, we demonstrate the role of the mesodiencephalic dopaminergic neurons (substantia nigra pars compacta and ventral tegmental area) as an intermediate target for the correct medial habenular axons navigation along the anteroposterior axis. These neuronal populations are distributed along the anteroposterior trajectory of these axons in the mesodiencephalic basal plate. Using in vitro and in vivo experiments, we determined that this navigation is the result of netrin 1 attraction generated by the mesodiencephalic dopaminergic neurons. This attraction is mediated by the receptor deleted in colorectal cancer (DCC), which is strongly expressed in the medial habenular axons. The increment in our knowledge on the fasciculus retroflexus trajectory guidance mechanisms opens the possibility of analyzing if its alteration in mental health patients could account for some of their symptoms
Keywords/Subjects:
DCC
axon guidance
fasciculus retroflexus
habenula
netrin 1
substantia nigra pars compacta
ventral tegmental area
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
DOI:
https://doi.org/10.3389/fcell.2021.682067
Appears in Collections:
Artículos Patología y Cirugía



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