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https://hdl.handle.net/11000/31148
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Falco, Antonio | - |
dc.contributor.author | CHICO GRAS, VERONICA | - |
dc.contributor.author | Marroquí, L. | - |
dc.contributor.author | Perez, L. | - |
dc.contributor.author | Coll, J.M. | - |
dc.contributor.author | Estepa, A. | - |
dc.date.accessioned | 2024-02-06T12:13:30Z | - |
dc.date.available | 2024-02-06T12:13:30Z | - |
dc.date.created | 2007-06 | - |
dc.identifier.citation | Molecular Immunology Volume 45, Issue 3, February 2008, Pages 757-765 | es_ES |
dc.identifier.issn | 0161-5890 | - |
dc.identifier.uri | https://hdl.handle.net/11000/31148 | - |
dc.description.abstract | The in silico identification of a β-defensin-like peptide sequence (omBD-1) in the rainbow trout (Oncorhynchuss mykiss) database of salmonid EST is reported here. We have studied the transcript expression of this β-defensin-like sequence in different organs and expressed the recombinant peptide in a fish cell line. Finally, we have demonstrated the in vitro antiviral activity of the recombinant trout β-defensin-like peptide against viral haemorrhagic septicaemia rhabdovirus (VHSV), one of the most devastating viruses for worldwide aquaculture. Thus, the resistance to VHSV infection of EPC cells transfected with pMCV 1.4-omBD-1 has been shown. Since EPC cells transfected with omBD-1 produced acid and heat stable antiviral activity and up regulation of Mx, a type I IFN-mediated mechanism of antiviral action is suggested. To our knowledge, this is the first report showing biological activity of a β-defensin-like peptide from any fish. | es_ES |
dc.format | application/pdf | es_ES |
dc.format.extent | 9 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Antimicrobial | es_ES |
dc.subject | Defensin | es_ES |
dc.subject | VHSV | es_ES |
dc.subject | IFN | es_ES |
dc.subject | Mx | es_ES |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::573 - Biología general y teórica | es_ES |
dc.title | Expression and antiviral activity of a β-defensin-like peptide identified in the rainbow trout (Oncorhynchus mykiss) EST sequences | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.contributor.institute | Institutos de la UMH::Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.molimm.2007.06.358 | es_ES |
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