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dc.contributor.authorMoreno Pérez, Óscar-
dc.contributor.authorPortilla Sogorb, Joaquín-
dc.contributor.authorEscoín, C.-
dc.contributor.authorALFAYATE-
dc.contributor.authorReus, S.-
dc.contributor.authorMerino de Lucas, Esperanza-
dc.contributor.authorBoix Martínez, Vicente-
dc.contributor.authorBernabeu, A.-
dc.contributor.authorGiner, L.-
dc.contributor.authorMauri, M.-
dc.contributor.authorSánchez Payá, José-
dc.contributor.authorPicó Alfonso, Antonio Miguel-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.contributor.otherDepartamentos de la UMH::Salud Pública, Historia de la Ciencia y Ginecologíaes_ES
dc.date.accessioned2024-02-06T06:50:30Z-
dc.date.available2024-02-06T06:50:30Z-
dc.date.created2013-03-
dc.identifier.citationHIV Medicine 2013 Oct;14(9):540-8es_ES
dc.identifier.issn1464-2662-
dc.identifier.issn1468-1293-
dc.identifier.urihttps://hdl.handle.net/11000/31135-
dc.description.abstractObjectives: Vitamin D is thought to play a role in glucose homeostasis and beta cell function. Our aim was to examine the impact of plasma 25-hydroxyvitamin D [25(OH)D] upon in vivo insulin sensitivity and beta cell function in HIV-infected male patients without diabetes. Methods: A cross-sectional study was carried out involving a cohort of HIV-infected patients undergoing regular assessment in a tertiary hospital. Eighty-nine patients [mean (± standard deviation) age 42 ± 8 years] were included in the study: 14 patients were antiretroviral therapy (ART)-naïve, while 75 were on ART. Vitamin D insufficiency (VDI) was defined as 25(OH)D < 75 nmol/L; insulin sensitivity was determined using a 2-h continuous infusion of glucose model assessment with homeostasis (CIGMA-HOMA), using the trapezoidal model to calculate the incremental insulin and glucose areas under the curve (AUCins and AUGglu, respectively). Beta cell function was assessed using the disposition index (DI). Abdominal visceral adipose tissue (VAT) and hepatic triglyceride content (HTGC) were measured by magnetic resonance imaging (MRI) and 1-H magnetic resonance spectroscopy. Multivariate linear regression analysis was performed. Results: VDI was associated with insulin resistance (IR), as indicated by a higher CIGMA-HOMA index (odds ratio 1.1) [1.01-1.2]. This association was independent of the main confounders, such as age, Centers for Disease Control and Prevention (CDC) stage, ART, lipodystrophy, body mass index, VAT:subcutaneous adipose tissue ratio and HTGC, as confirmed by multivariate analysis (B = 12.3; P = 0.01; r² = 0.7). IR in patients with VDI was compensated by an increase in insulin response. However, beta cell function was lower in the VDI subpopulation (33% decrease in DI). Conclusions: VDI in nondiabetic HIV-positive male patients is associated with impaired insulin sensitivity and a decrease in pancreatic beta cell functiones_ES
dc.formatapplication/pdfes_ES
dc.format.extent10es_ES
dc.language.isoenges_ES
dc.publisherWiley [Commercial Publisher]es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHIVes_ES
dc.subjectabdominal visceral fates_ES
dc.subjectbeta celles_ES
dc.subjectinsulin homeostasises_ES
dc.subjectliver steatosises_ES
dc.subjectvitamin D deficiencyes_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::614 - Higiene y salud pública. Contaminación. Prevención de accidentes. Enfermeríaes_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes_ES
dc.titleImpact of vitamin D insufficiency on insulin homeostasis and beta cell function in nondiabetic male HIV-infected patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1111/hiv.12042es_ES
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