Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31120
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dc.contributor.authorArroyo, Antonio-
dc.contributor.authorSánchez-Guillén, Luis-
dc.contributor.authorAntonio Parra, Pedro-
dc.contributor.authorGarcía‐Catalá, Luís-
dc.contributor.authorPeña‐Ros, Emilio-
dc.contributor.authorFerrer‐Márquez, Manuel-
dc.contributor.authornofuentes, carmen-
dc.contributor.authorBarber‐Valles, Xavier-
dc.contributor.authorROMERO SIMÓ, MANUEL-
dc.contributor.otherDepartamentos de la UMH::Patología y Cirugíaes_ES
dc.date.accessioned2024-02-05T18:39:09Z-
dc.date.available2024-02-05T18:39:09Z-
dc.date.created2020-
dc.identifier.citationLasers in Surgery and Medicine. 2020 Jul;52(6):503-508es_ES
dc.identifier.issn1096-9101-
dc.identifier.issn0196-8092-
dc.identifier.urihttps://hdl.handle.net/11000/31120-
dc.description.abstractBackground and objectives: To validate and analyze the results of intralesional photodynamic therapy in the treatment of complex anal fistula. Study design/materials and methods: This prospective multicentric observational study enrolled patients treated for complex anal fistula who underwent intralesional photodynamic therapy (i-PDT). The included patients were treated from January 2016 to December 2018 with a minimum follow-up of 1 year to evaluate recurrence, continence and postoperative morbidity. Intralesional 5-aminolevulinic acid (ALA) gel (2%) was injected directly into the fistula. The internal and external orifices were closed. After an incubation period of 2 hours, the fistula was irradiated using an optical fiber connected to a red laser (Multidiode 630 PDT) operating at 1 W/cm for 3 minutes (180 J). Results: In total, 49 patients were included (61.2% male). The mean age was 48 years, and the mean duration of fistula was 13 months. Of the fistulas included, 75.5% were medium transphincteric, and 24.5% were high transphincteric. The median fistula length was 4 ± 1,14 cm (range: 3-5). A total of 41 patients (83.7%) had a previous history of fistula surgery. Preoperatively, some degree of anal incontinence was found in 5 patients (10.2%). No center reported any other procedure-related complications intraoperatively. Phototoxicity was found in one patient. In the first 48 hours after the procedure, fever was reported in 2 patients (4%). At the end of follow-up, total healing was observed in 32/49 patients (65.3%). No patient reported new incontinence postoperatively. Conclusion: i-PDT could be considered a good choice in patients with complex anal fistulas to avoid surgery and its complications. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent6es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcomplex anal fistulaes_ES
dc.subjectincontinencees_ES
dc.subjectphotodynamic therapyes_ES
dc.subjectproctologyes_ES
dc.subjectsurgeryes_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes_ES
dc.titlePhotodynamic Therapy for the Treatment of Complex Anal Fistulaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1002/lsm.23162es_ES
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Artículos Patología y Cirugía


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