Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/11000/31105

Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients


no-thumbnailVer/Abrir:

 Bacterial antigen translocation and age as BMI-independent.pdf



1,17 MB
Adobe PDF
Compartir:

Este recurso está restringido

Título :
Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients
Autor :
Gómez-Hurtado, Isabel
Gallego-Durán, Rocío  
Zapater, Pedro
Ampuero, Javier  
Aller, Rocío
Crespo, Javier
Arias-Loste, María Teresa  
García-Monzón, Carmelo
Bellot, Pablo
González-Rodríguez, Águeda
Juanola, Oriol
Romero Gómez, Manuel  
Francés, Rubén
Editor :
Wiley
Departamento:
Departamentos de la UMH::Medicina Clínica
Fecha de publicación:
2020
URI :
https://hdl.handle.net/11000/31105
Resumen :
Background & aims: Low-grade systemic inflammation is a crucial landmark in NAFLD favouring disease progression and comorbidities. We evaluated the input of circulating bacterial antigens on systemic markers of inflammation in NAFLD patients.Patients & methods: Multicenter cross-sectional study including consecutive patients with biopsy-proven NAFLD. Demographic, metabolic and fibrosis-related variables were collected. Circulating bacterial antigens were quantified in blood. Toll-like receptor SNPs were genotyped. Serum cytokine levels were evaluated. Peripheral blood mononuclear cell response to bacterial antigens was evaluated in vitro.Results: Three hundred and fifteen patients from five Spanish hospitals were distributed by BMI. At least, one bacterial antigenic type was found in 66 patients with BMI < 30 (63.4%) and 163 patients with BMI > 30 (77.3%) (P = .014). HOMA-IR was significantly higher in the presence of circulating antigens among patients with BMI < 30. NASH and significant fibrosis in non-obese patients were more frequent in the presence of at least two circulating antigenic types. Allelic frequencies of TLR variants were similar to controls and did not affect clinical or laboratory parameters. Pro-inflammatory cytokines were significantly increased in patients with bacterial antigens, regardless of BMI. TLR gene and protein expression levels were significantly increased in PBMCs from patients with bacterial antigens. Antigen concentrations independently influenced TNF-α and IL-6, in both BMI subgroups of patients. Age independently influenced TNF-α and IL-6 in non-obese patients, and TNF-α in obese patients.Conclusion: Serum circulating bacterial antigens as well as age were BMI-independent factors related to increased systemic inflammation in NAFLD and provides insight on the multifaceted sources of inflammation in these patients.
Palabras clave/Materias:
NAFLD
aging
bacterial translocation
cytokines
insulin resistance
Área de conocimiento :
CDU: Ciencias aplicadas: Medicina: Patología. Medicina clínica. Oncología
Tipo de documento :
info:eu-repo/semantics/article
Derechos de acceso:
info:eu-repo/semantics/closedAccess
DOI :
https://doi.org/10.1111/liv.14571
Aparece en las colecciones:
Artículos Medicina Clínica



Creative Commons La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.