Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31091
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dc.contributor.authorPortilla, Joaquin-
dc.contributor.authorMoreno-Pérez, Oscar-
dc.contributor.authorSerna-Candel, Carmen-
dc.contributor.authorEscoín, Corina-
dc.contributor.authorALFAYATE-
dc.contributor.authorReus, Sergio-
dc.contributor.authorMerino, Esperanza-
dc.contributor.authorBoix, Vicente-
dc.contributor.authorGiner, Livia-
dc.contributor.authorSánchez-Payá, José-
dc.contributor.authorPicó, Antonio-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.date.accessioned2024-02-05T17:52:54Z-
dc.date.available2024-02-05T17:52:54Z-
dc.date.created2014-
dc.identifier.citationJournal of the International AIDS Society . 2014 May 13;17(1):18945es_ES
dc.identifier.issn1758-2652-
dc.identifier.urihttps://hdl.handle.net/11000/31091-
dc.description.abstractIntroduction: Vitamin D insufficiency (VDI) has been associated with increased cardiovascular risk in the non-HIV population. This study evaluates the relationship among serum 25-hydroxyvitamin D [25(OH)D] levels, cardiovascular risk factors, adipokines, antiviral therapy (ART) and subclinical atherosclerosis in HIV-infected males.Methods: A cross-sectional study in ambulatory care was made in non-diabetic patients living with HIV. VDI was defined as 25(OH)D serum levels <75 nmol/L. Fasting lipids, glucose, inflammatory markers (tumour necrosis factor-α, interleukin-6, high-sensitivity C-reactive protein) and endothelial markers (plasminogen activator inhibitor-1, or PAI-I) were measured. The common carotid artery intima-media thickness (C-IMT) was determined. A multivariate logistic regression analysis was made to identify factors associated with the presence of VDI, while multivariate linear regression analysis was used to identify factors associated with common C-IMT.Results: Eighty-nine patients were included (age 42 ± 8 years), 18.9% were in CDC (US Centers for Disease Control and Prevention) stage C and 75 were on ART. VDI was associated with ART exposure, sedentary lifestyle, higher triglycerides levels and PAI-I. In univariate analysis, VDI was associated with greater common C-IMT. The multivariate linear regression model, adjusted by confounding factors, revealed an independent association between common C-IMT and patient age, time of exposure to protease inhibitors (PIs) and impaired fasting glucose (IFG). In contrast, there were no independent associations between common C-IMT and VDI or inflammatory and endothelial markers.Conclusions: VDI was not independently associated with subclinical atherosclerosis in non-diabetic males living with HIV. Older age, a longer exposure to PIs, and IFG were independent factors associated with common C-IMT in this population.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent8es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHIVes_ES
dc.subjectadipokineses_ES
dc.subjectantiretroviral treatmentes_ES
dc.subjectatherosclerosises_ES
dc.subjectcarotid intima media thicknesses_ES
dc.subjectvitamin D insufficiencyes_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes_ES
dc.titleVitamin D insufficiency and subclinical atherosclerosis in non-diabetic males living with HIVes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.7448/IAS.17.1.18945es_ES
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Artículos Medicina Clínica


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