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Functional interplay between secreted ligands and receptors in melanoma


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Título :
Functional interplay between secreted ligands and receptors in melanoma
Autor :
Herraiz, Celia
Jiménez-Cervantes, Celia  
Sanchez-Laorden, Berta  
García-Borrón, José C.
Editor :
Elsevier
Fecha de publicación:
2017-07-01
URI :
https://hdl.handle.net/11000/30786
Resumen :
Melanoma, the most aggressive form of skin cancer, results from the malignant transformation of melanocytes located in the basement membrane separating the epidermal and dermal skin compartments. Cutaneous melanoma is often initiated by solar ultraviolet radiation (UVR)-induced mutations. Melanocytes intimately interact with keratinocytes, which provide growth factors and melanocortin peptides acting as paracrine regulators of proliferation and differentiation. Keratinocyte-derived melanocortins activate melanocortin-1 receptor (MC1R) to protect melanocytes from the carcinogenic effect of UVR. Accordingly, MC1R is a major determinant of susceptibility to melanoma. Despite extensive phenotypic heterogeneity and high mutation loads, the molecular basis of melanomagenesis and the molecules mediating the crosstalk between melanoma and stromal cells are relatively well understood. Mutations of intracellular effectors of receptor tyrosine kinase (RTK) signalling, notably NRAS and BRAF, are major driver events more frequent than mutations in RTKs. Nevertheless, melanomas often display aberrant signalling from RTKs such as KIT, ERRB1-4, FGFR, MET and PDGFR, which contribute to disease progression and resistance to targeted therapies. Progress has also been made to unravel the role of the tumour secretome in preparing the metastatic niche. However, key aspects of the melanoma-stroma interplay, such as the molecular determinants of dormancy, remain poorly understood.
Palabras clave/Materias:
Melanoma
Melanocortin-1 receptor
Receptor tyrosine kinase signalling
Melanoma progression
Resistance to targeted therapies
Therapy-induced secretome
Tipo documento :
application/pdf
Derechos de acceso:
info:eu-repo/semantics/closedAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
DOI :
https://doi.org/10.1016/j.semcdb.2017.06.021
Aparece en las colecciones:
Instituto de Neurociencias



Creative Commons La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.