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Microenvironmental Snail1-induced immunosuppression promotes melanoma growth


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Título :
Microenvironmental Snail1-induced immunosuppression promotes melanoma growth
Autor :
Arumí Planas, Marta  
Rodríguez Baena, Francisco Javier  
Cabello-Torres, Francisco
Gracia, Francisco
López-Blau, Cristina  
Nieto, Ángela M.
Sanchez-Laorden, Berta  
Editor :
Springer Nature
Fecha de publicación:
2023
URI :
https://hdl.handle.net/11000/30782
Resumen :
Melanoma is an aggressive form of skin cancer due to its high metastatic abilities and resistance to therapies. Melanoma cells reside in a heterogeneous tumour icroenvironment that acts as a crucial regulator of its progression. Snail1 is an epithelial-tomesenchymal transition transcription factor expressed during development and reactivated in pathological situations including fibrosis and cancer. In this work, we show that Snail1 is activated in the melanoma microenvironment, particularly in fibroblasts. Analysis of mouse models that allow stromal Snail1 depletion and therapeutic Snail1 blockade indicate that targeting Snail1 in the tumour microenvironment decreases melanoma growth and lung metastatic burden, extending mice survival. Transcriptomic analysis of melanoma-associated fibroblasts and analysis of the tumours indicate that stromal Snail1 induces melanoma growth by promoting an immunosuppressive microenvironment and a decrease in anti-tumour immunity. This study unveils a novel role of Snail1 in melanoma biology and supports its potential as a therapeutic target
Tipo documento :
application/pdf
Derechos de acceso:
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
DOI :
https://doi.org/10.1038/s41388-023-02793-5
Aparece en las colecciones:
Instituto de Neurociencias



Creative Commons La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.