Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/30718
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dc.contributor.authorFuster, Encarnación-
dc.contributor.authorCandela, Héctor-
dc.contributor.authorJorge, Estévez-
dc.contributor.authorVilanova, Eugenio-
dc.contributor.authorSOGORB, MIGUEL A-
dc.contributor.otherDepartamentos de la UMH::Biología Aplicadaes_ES
dc.date.accessioned2024-01-26T10:30:28Z-
dc.date.available2024-01-26T10:30:28Z-
dc.date.created2021-02-12-
dc.identifier.citationInternational Journal of Molecular Sciences, 2021, 22, 2084es_ES
dc.identifier.issn1422-0067-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://hdl.handle.net/11000/30718-
dc.description.abstractTitanium dioxide and zinc oxide are two of the most widely used nanomaterials. We assessed the effects of noncytotoxic doses of both nanomaterials on T98G human glioblastoma cells by omic approaches. Surprisingly, no effects on the transcriptome of T98G cells was detected after exposure to 5 g/mL of zinc oxide nanoparticles during 72 h. Conversely, the transcriptome of the cells exposed to 20 g/mL of titanium dioxide nanoparticles during 72 h revealed alterations in lots of biological processes and molecular pathways. Alterations to the transcriptome suggests that exposure to titanium dioxide nanoparticles might, potentially, compromise the integrity of the blood brain barrier integrity and cause neuroinflammation. The latter issue was further confirmed phenotypically with a proteomic analysis and by recording the release of interleukin 8. Titanium dioxide also caused autophagy, which was demonstrated through the increase in the expression of the autophagy-related 3 and microtubule associated protein 1 light chain 3 alpha genes. The proteomic analysis revealed that titanium dioxide nanoparticles might have anticancerigen properties by downregulating genes involved in the detoxication of anthracyclines. A risk assessment resulting from titanium dioxide exposure, focusing on the central nervous system as a potential target of toxicity, is necessary.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent26es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjecttitanium dioxide nanoparticleses_ES
dc.subjectzinc oxide nanoparticleses_ES
dc.subjectT98G human glioblastomaes_ES
dc.subjectnanotoxicologyes_ES
dc.subjectomicses_ES
dc.subjectneurotoxicityes_ES
dc.subjectneuroinflammationes_ES
dc.subjectcell toxicityes_ES
dc.subjecttoxicologyes_ES
dc.subjecthuman healthes_ES
dc.subject.classificationToxicologíaes_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biologíaes_ES
dc.titleTitanium Dioxide, but Not Zinc Oxide, Nanoparticles Cause Severe Transcriptomic Alterations in T98G Human Glioblastoma Cellses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms22042084es_ES
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