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Solitary pulmonary nodule malignancy predictive models applicable to routine clinical practice: a systematic review


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Título :
Solitary pulmonary nodule malignancy predictive models applicable to routine clinical practice: a systematic review
Autor :
Senent Valero, Marina  
Librero, Julian  
Pastor-Valero, Maria  
Editor :
BMC
Departamento:
Departamentos de la UMH::Salud Pública, Historia de la Ciencia y Ginecología
Fecha de publicación:
2021-12
URI :
https://hdl.handle.net/11000/30549
Resumen :
Background: Solitary pulmonary nodule (SPN) is a common finding in routine clinical practice when performing chest imaging tests. The vast majority of these nodules are benign, and only a small proportion are malignant. The application of predictive models of nodule malignancy in routine clinical practice would help to achieve better diagnostic management of SPN. The present systematic review was carried out with the purpose of critically assessing studies aimed at developing predictive models of solitary pulmonary nodule (SPN) malignancy from SPN incidentally detected in routine clinical practice. Methods: We performed a search of available scientific literature until October 2020 in Pubmed, SCOPUS and Cochrane Central databases. The inclusion criteria were observational studies carried out in low-risk population from 35 years old onwards aimed at constructing predictive models of malignancy of pulmonary solitary nodule detected incidentally in routine clinical practice. Studies had to be published in peer-reviewed journals, either in Spanish, Portuguese or English. Exclusion criteria were non-human studies, or predictive models based in high-risk populations, or models based on computational approaches. Exclusion criteria were non-human studies, or predictive models based in high-risk populations, or models based on computational approaches (such as radiomics). We used The Transparent Reporting of a multivariable Prediction model for Individual Prognosis Or Diagnosis (TRIPOD) statement, to describe the type of predictive model included in each study, and The Prediction model Risk Of Bias ASsessment Tool (PROBAST) to evaluate the quality of the selected articles. Results: A total of 186 references were retrieved, and after applying the exclusion/inclusion criteria, 15 articles remained for the final review. All studies analysed clinical and radiological variables. The most frequent independent predictors of SPN malignancy were, in order of frequency, age, diameter, spiculated edge, calcification and smoking history. Variables such as race, SPN growth rate, emphysema, fibrosis, apical scarring and exposure to asbestos, uranium and radon were not analysed by the majority of the studies. All studies were classified as high risk of bias due to inadequate study designs, selection bias, insufficient population follow-up and lack of external validation, compromising their applicability for clinical practice. Conclusions: The studies included have been shown to have methodological weaknesses compromising the clinical applicability of the evaluated SPN malignancy predictive models and their potential influence on clinical decisionmaking for the SPN diagnostic management.
Palabras clave/Materias:
Solitary pulmonary nodule
Prediction models
Lung neoplasms
Clinical setting
Systematic review
Área de conocimiento :
CDU: Ciencias aplicadas: Medicina
Tipo de documento :
info:eu-repo/semantics/article
Derechos de acceso:
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
DOI :
https://doi.org/10.1186/s13643-021-01856-6
Aparece en las colecciones:
Artículos Salud Pública, Historia de la Ciencia y Ginecología



Creative Commons La licencia se describe como: Atribución-NonComercial-NoDerivada 4.0 Internacional.