Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/30481

Etiopathogenesis of Transient Ischemic Attacks and Minor Ischemic Strokes


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Title:
Etiopathogenesis of Transient Ischemic Attacks and Minor Ischemic Strokes
Authors:
Perez-Sempere, Angel  
Duarte, Jacinto
Cabezas, Carmen  
Clavería, Luis Erik
Editor:
MD
Department:
Departamentos de la UMH::Medicina Clínica
Issue Date:
1998-01
URI:
https://hdl.handle.net/11000/30481
Abstract:
Background and Purpose—We sought to analyze the etiology and underlying vascular risk factors of transient ischemic attacks (TIAs) and minor ischemic strokes (MISs). Methods—We prospectively studied the vascular risk factors and etiologic categories in 235 patients with TIAs and MISs from a community-based register in a rural area of Spain. Five etiologic categories were considered: (1) cardioembolism, (2) large-artery atherosclerosis, (3) small-artery disease, (4) other etiologies, and (5) undetermined etiology. Systematic investigations included neuroimaging (CT/MRI) and vascular studies (duplex scan/MR angiography and angiography in selected cases). Results—The two most frequent etiologic categories were small-artery disease (31%) and cardioembolism (26%). Large-artery atherosclerosis was detected in 11% of the patients. Significant carotid stenosis (≥50%) was present in 13% of patients with carotid territory events. No cause could be found or it was uncertain in almost one third of the patients. The distribution of etiologic categories was similar in TIAs and MISs. The most prevalent vascular risk factors were as follows: arterial hypertension (50%), smoking (26%), atrial fibrillation (20%), hypercholesterolemia (17%), diabetes (15%), ischemic heart disease (12%), and peripheral vascular disease (3%). Carotid bruits were detected in 3% of the patients. Conclusions—An etiologic classification of TIAs and MISs is feasible. The two most frequent pathogenetic mechanisms in our study were small-artery disease and cardioembolism. The prevalence of large-artery atherosclerosis was low.
Keywords/Subjects:
atherosclerosis
carotid arteries
cerebral ischemia
transient
etiology
risk factors
Knowledge area:
CDU: Ciencias aplicadas: Medicina
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
DOI:
https://doi.org/10.1161/01.STR.29.1.40
Appears in Collections:
Artículos Medicina Clínica



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