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dc.contributor.authorFernández Jover, Eduardo-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.description.abstractBACKGROUND. A long-held goal of vision therapy is to transfer information directly to the visual cortex of blind individuals, thereby restoring a rudimentary form of sight. However, no clinically available cortical visual prosthesis yet exists. METHODS. We implanted an intracortical microelectrode array consisting of 96 electrodes in the visual cortex of a 57-year-old person with complete blindness for a 6-month period. We measured thresholds and the characteristics of the visual percepts elicited by intracortical microstimulation. RESULTS. Implantation and subsequent explantation of intracortical microelectrodes were carried out without complications. The mean stimulation threshold for single electrodes was 66.8 ± 36.5 μA. We consistently obtained high-quality recordings from visually deprived neurons and the stimulation parameters remained stable over time. Simultaneous stimulation via multiple electrodes was associated with a significant reduction in thresholds (P < 0.001, ANOVA) and evoked discriminable phosphene percepts, allowing the blind participant to identify some letters and recognize object boundaries. CONCLUSIONS. Our results demonstrate the safety and efficacy of chronic intracortical microstimulation via a large number of electrodes in human visual cortex, showing its high potential for restoring functional vision in the blind.es_ES
dc.description.sponsorshipThe Spanish Ministerio de Ciencia Innovación y Universidades-
dc.description.sponsorshipThe Generalitat Valenciana (Spain)-
dc.description.sponsorshipThe Europan Union’s Horizon 2020 programme-
dc.description.sponsorshipThe Bidons Egara Research Chair of the University Miguel Hernández (Spain)-
dc.description.sponsorshipThe John Moran Eye Center of the University of Utah.-
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes_ES
dc.titleVisual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortexes_ES
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