https://hdl.handle.net/11000/7 Fri, 10 Jul 2026 15:43:10 GMT 2026-07-10T15:43:10Z https://hdl.handle.net/11000/40180 Título : La celebración de negocios jurídicos por parte de las personas con discapacidad intelectual: entre capacidad jurídica e interés superior Autor : Ortiz Fernández, Manuel Resumen : El presente trabajo se enmarca en la línea de investigación desarrollada por el Gru- po de investigación Persona, vulnerabilidad y Derecho. Así mismo, se encuadra en el proyecto de investigación "Desafíos actuales para los derechos fundamenta- les y nuevos retos de las políticas públicas: gobernanza democrática, brechas de la desigualdad e inteligencia artificial", con referencia PID2023-147126OB-I00, concedido por el Ministerio de Ciencia, Innovación y Universidades y del que son Investigadores Principales la profesora Ángeles Ródenas Calatayud y el profesor Fernando Ballester Laguna. Realizado también al amparo del proyecto de investigación "Las personas mayo- res ante la vulnerabilidad, la exclusión y la soledad. Mecanismos jurídico-civiles de protección y propuestas desde un enfoque multidisciplinar", con referencia PID2024-159716OB-I00, concedido por el Ministerio de Ciencia, Innovación y Universidades y del son Investigadores Principales la profesora Cristina López Sánchez y el profesor Pedro Femenía López. Además, el presente estudio forma parte de la actividad desarrollada por la Cáte- dra del Sistema Público Valenciano de Servicios Sociales de la Universidad Miguel Hernández de Elche que, a su vez, se enmarca en el Convenio de colaboración suscrito entre la Generalitat, a través de la Vicepresidencia Segunda y Conselleria de Servicios Sociales, Igualdad y Vivienda, y la Universidad de Alicante, la Uni- versitat Jaume I, la Universidad Miguel Hernández, la Universitat Politècnica de València y la Universitat de València-Estudi General, para el fomento de la inves- tigación en servicios sociales de la Comunitat Valenciana para el ejercicio 2026. Fri, 10 Jul 2026 08:08:06 GMT https://hdl.handle.net/11000/40180 2026-07-10T08:08:06Z https://hdl.handle.net/11000/40179 Título : La protección de los menores de edad en el metaverso: una lectura desde el apartado X de la carta de derechos digitales Autor : Ortiz Fernández, Manuel Resumen : El Metaverso presenta múltiples desafíos para los menores de edad. A los indudables beneficios que puede generar para este colectivo, hay que oponer los evidentes riesgos que existen. Por este motivo, es necesario establecer una adecuada protección de sus derechos y articular mecanismos que permitan la identificación de la edad y el control parental. La normativa ha de esclarecer el papel que han de desempeñar a tal efecto los padres y tutores y debe dotarles de herramientas suficientes para intervenir en este ámbito. Además, las reglas que deben cumplir los proveedores y plataformas han de ser precisas y proporcionar seguridad jurídica. En cuanto a la tutela de los derechos, se ha de dilucidar si se indemnizan en la medida (y solo en la medida) en que tengan traslación al mundo físico o si, por el contrario, podemos encontrar daños en el mundo virtual por existir bienes jurídicos digitales. Desde esta perspectiva, hemos de analizar el apartado X de la Carta de Derechos Digitales, dedicado a la protección de los menores de edad en el entorno digital y estudiar cómo se aplican sus previsiones en el ámbito del Metaverso. Fri, 10 Jul 2026 08:05:53 GMT https://hdl.handle.net/11000/40179 2026-07-10T08:05:53Z https://hdl.handle.net/11000/40164 Título : Exposure to Obesogenic Endocrine Disruptors in Childhood. Impact on Biomarkers of Metabolic Status. Autor : Nso-Roca, Ana Pilar; Tortajada-Genaro, Luis A.; Pons Fernández, Natividad; Sánchez Ferrer, Francisco Resumen : Childhood obesity is an escalating global health concern, partly driven by environmental factors such as endocrine disruptors (EDs), which can alter metabolism and promote adiposity. This cross-sectional study examined exploratory associations between exposure to obesogenic EDs (bisphenols, parabens and benzophenones) and body composition in 72 children aged 3 to 15 years (53 with obesity and 19 normal-weight controls) recruited from two hospitals in Spain. Metabolic status, body composition and urinary levels of EDs were evaluated using tandem mass spectrometry. The findings, which are pioneering in evaluating multiple exposure to chemicals, identify exploratory associations between the presence of EDs in 100% of the participants, with parabens the most frequently detected. Higher methylparaben levels were observed in the group with obesity. Correlational analyses revealed positive associations between specific EDs and adiposity parameters, including triponderal mass index and visceral fat percentage. These results suggest a potential link between exposure to EDs and the development of childhood obesity. The massive and early exposure to EDs underscores the urgent need for preventive policies and longitudinal studies to evaluate their effects. These preliminary findings provide exploratory insights for developing effective strategies to combat childhood obesity. Thu, 09 Jul 2026 10:54:54 GMT https://hdl.handle.net/11000/40164 2026-07-09T10:54:54Z https://hdl.handle.net/11000/40163 Título : Evolutive study of children with diffuse mesangial sclerosis. Autor : Nso-Roca, Ana Pilar; Peña Carrión, Antonia; Benito Gutiérrez, Marta; GARCÍA POSE, ARACELI; Navarro, Mercedes Resumen : Diffuse mesangial sclerosis (DMS) is a renal disease that usually presents as a nephrotic syndrome. It is characterized by early onset and rapid progression to endstage renal disease, and can occur as an isolated finding or as part of the Denys-Drash syndrome. The aim of this study was to characterize clinical features and outcomes of DMS in a cohort of children. We retrospectively analyzed all cases of DMS diagnosed in our hospital between 1973 and 2008 and evaluated the progression of the disease in relation to different variables. We studied 14 patients, four with incomplete Denys-Drash syndrome and one with Frasier syndrome. All patients developed renal failure. Eight patients received a renal transplant with no relapse of the disease. Bilateral nephrectomy was performed in nine patients with end-stage renal disease. Seven patients died, with sepsis being the main cause of death. Diffuse mesangial sclerosis must be suspected in a child that presents with early onset proteinuria and/or rapidly progressive renal failure. Karyotype and WT1 gene analysis should be performed because of the predisposition of patients to develop different types of tumors. This nephropathy has a poor prognosis, but the survival rate has improved in the last decade. Thu, 09 Jul 2026 10:54:09 GMT https://hdl.handle.net/11000/40163 2026-07-09T10:54:09Z https://hdl.handle.net/11000/40162 Título : HIV-infected adolescents: relationship between atazanavir plasma levels and bilirubin concentrations. Autor : Nso-Roca, Ana Pilar; Larru Martinez, Beatriz; Bellón Cano, José María; Mellado Peña, Maria José; Ramos, José Tomás; Gonzalez Tome, Maria Isabel; Navarro, Maria Luisa; MUÑOZ, MARIA ANGELES; de José, Maria Isabel Resumen : Theuseofatazanavir(ATV)inadolescentsinfectedwithhumanimmunodeficiencyviruswasanalyzedinthis study. ATV morning plasma concentrations were determined during regular visits to the outpatient department. Results showed that bilirubin levels were higher among patients with higher ATV plasma concentrations (p .018). Monitoring plasma levels of ATV could avoid toxicity in these patients. Thu, 09 Jul 2026 10:52:42 GMT https://hdl.handle.net/11000/40162 2026-07-09T10:52:42Z https://hdl.handle.net/11000/40161 Título : Measurement Properties of the Spanish Version of the Engagement in Meaningful Activities Survey in Parents of Children with Developmental Challenges Autor : Noce, Paula; Muñoz-Sánchez, Rocío; Juárez Leal, Iris; Piñero Peñalver, Jessica; Siendones Molina, Mónica; HURTADO-POMARES, MIRIAM; Navarrete-Muñoz, Eva María; Valera-Gran, Desirée Resumen : Parents of children with developmental challenges often face constraints that reduce engagement in meaningful activities (MA). This study evaluated the measurement properties of the Spanish version of the Engagement in Meaningful Activities Survey (EMAS) in this population. Methods A convenience sample of 688 Spanish parents (468 mothers, 220 fathers) of children with developmental challenges completed the Spanish EMAS, Occupational Balance Questionnaire (OBQ), Parental Stress Scale (PSS; Baby’s Rewards [PSS-BR] and Stressors [PSS-S]), Hospital Anxiety and Depression Scale (HADS-A, HADS-D), and Psychological Well-Being Scale (PWBS). Internal consistency, test-retest reliability, structural, and construct validity were examined. Consumer and Community Involvement There was no consumer or community involvement in this study. Results EMAS scores averaged 31.1 (standard deviation [SD] = 7.1) for mothers and 33.4 (SD = 6.4) for fathers, with no floor or ceiling effects. Internal consistency was high (α = 0.88 for mothers; α =0 .86 for fathers). Test-retest reliability in mothers (n = 75) was moderate (intraclass correlation coefficient [ICC] = 0.59, 95% confidence interval [CI]: 0.42, 0.72; rs =0 .62). A two-factor structure showed acceptable fit. Construct validity was supported through correlations with OBQ (rsm [mothers] = 0.61; rsf [fathers] = 0.63), HADS-A (rsm = -0.41; rsf = -0.36), HADS-D (rsm = -0.50; rsf = -0.47), PSS-BR (rsm = 0.37; rsf = 0.31), PSS-S (rsm = -0.25; rsf = -0.26), and PWBS (rsm = 0.46; rsf = 0.52). Conclusion The Spanish EMAS shows robust measurement properties for assessing engagement in MA among parents of children with developmental challenges. Its use may support family-centred interventions and research. Thu, 09 Jul 2026 10:48:43 GMT https://hdl.handle.net/11000/40161 2026-07-09T10:48:43Z https://hdl.handle.net/11000/40160 Título : La sostenibilidad y los ods desde el área de organización de empresas. Una propuesta de metodología docente para escalar modelos de negocio sostenibles. Autor : Sanchis Palacio, Joan Ramon; Campos Climent, Vanessa; Melian Navarro, Amparo; Ejarque Catalá, Ana Teresa Fri, 03 Jul 2026 10:32:43 GMT https://hdl.handle.net/11000/40160 2026-07-03T10:32:43Z https://hdl.handle.net/11000/40159 Título : Las Comunidades de Regantes: infraestructura y organización. Autor : Melián Navarro, María Amparo Fri, 03 Jul 2026 10:31:49 GMT https://hdl.handle.net/11000/40159 2026-07-03T10:31:49Z https://hdl.handle.net/11000/40158 Título : Propuesta de mejoras y su valoración. Autor : Melían Navarro, María Amparo; Ruiz Canales, Antonio Fri, 03 Jul 2026 10:31:07 GMT https://hdl.handle.net/11000/40158 2026-07-03T10:31:07Z https://hdl.handle.net/11000/40157 Título : Safety of Dupilumab Therapy for Atopic Dermatitis during Pregnancy: A Systematic Review and Meta-analysis Autor : Sánchez-García, Verónica; de Miguel Balsa, Eva; Ramos Rincón, José Manuel; Belinchón-Romero, Isabel Resumen : Atopic dermatitis (AD) is the most common skin condition among pregnant women. However, there is limited information on the safety of biologicals during pregnancy. A systematic review and meta-analysis was conducted following the PRISMA guidelines to evaluate the effects of exposure to biologicals during pregnancy and/or preconception in women with AD, and to estimate the pooled prevalence of spontaneous abortions and congenital malformations in their newborns. MEDLINE, Embase, Scopus, and Web of Science to 31 May 2024 were searched to identify randomized controlled trials and non-randomized studies. To test the robustness of our findings, sensitivity analyses were performed. Fifteen observational studies involving 115 pregnant women with a mean age of 33.46 years (standard deviation [SD] 3.02 were included). All studies evaluated dupilumab. The mean duration of exposure to dupilumab during pregnancy was 27.52 weeks (SD 11.16). The weighted prevalence of spontaneous abortions was 18.9% (95% confidence interval 5.3 to 38.2). There were no reports of congenital malformations. The sensitivity analyses showed no significant differences in weighted prevalences. In conclusion, the current scientific evidence suggests that dupilumab is probably safe during pregnancy and preconception in women with AD, with no significant increase in the risk of miscarriage or congenital malformations compared to the general population. However, the results of this review are inconclusive due to the limited number of large, well-designed clinical studies. Fri, 03 Jul 2026 10:28:46 GMT https://hdl.handle.net/11000/40157 2026-07-03T10:28:46Z