https://hdl.handle.net/11000/6 2026-08-04T04:50:07Z 2026-08-04T04:50:07Z Quesada, Jose A. López-Pineda, Adriana NOUNI GARCÍA, RAUF Cordero, Alberto Carbonell Soliva, Álvaro Esquerdo Arroyo, Amanda PEREIRA-EXPOSITO, AVELINO Guillen-García, Silvia Arrarte, Vicente Bertomeu-Gonzalez, Vicente Nolasco, Andreu Cazorla-Morallon, Diego Osende, Julio nalda-molina, Ricardo Orozco-Beltrán, Domingo Carratalá-Munuera, Concepción Gil-Guillén, Vicente F https://hdl.handle.net/11000/40320 2026-08-01T01:03:29Z 2026-07-31T11:05:30Z

Título : Development and internal validation of GENADHECAR: a screening instrument for identifying probable statin non-adherence in patients with ischemic heart disease Autor : Quesada, Jose A.; López-Pineda, Adriana; NOUNI GARCÍA, RAUF; Cordero, Alberto; Carbonell Soliva, Álvaro; Esquerdo Arroyo, Amanda; PEREIRA-EXPOSITO, AVELINO; Guillen-García, Silvia; Arrarte, Vicente; Bertomeu-Gonzalez, Vicente; Nolasco, Andreu; Cazorla-Morallon, Diego; Osende, Julio; nalda-molina, Ricardo; Orozco-Beltrán, Domingo; Carratalá-Munuera, Concepción; Gil-Guillén, Vicente F Resumen : Background: No validated and practical tool exists to assess adherence to statins in secondary prevention of cardiovascular disease. Current reference methods for assessing adherence, including plasma drug measurements, are not feasible for routine clinical care or large clinical trials. Objective: To develop and internally validate a predictive screening instrument for identifying patients at risk of statin non-adherence. Methods: This multicenter cross-sectional study reports the results of the second phase of the GENADHECAR project in four Spanish hospitals. An initial set of 42 adherence-related items was refined and evaluated in a sample of patients with ischemic heart disease. Responses were compared against a pharmacokinetic reference method (plasma statin concentrations) to assess recent medication intake. A multivariate predictive model of non-adherence was then developed, selecting the best predictors and covariates to be included in the final screening instrument. Results: A total of 309 patients were included, of whom 49 (15.9%) were classified as non-adherent according to the pharmacokinetic reference method. The final GENADHECAR screening instrument comprised three questionnaire items (use of reminders, forgetfulness, and medication access) and two sociodemographic variables (sex and educational attainment). Internal bootstrap validation yielded an optimism-corrected AUC of 0.694 (95% CI 0.617–0.767), with adequate calibration (Hosmer–Lemeshow p = 0.994). At the selected probability threshold (0.15), sensitivity was 0.73, specificity 0.61, and positive and negative predictive values were 0.26 and 0.92, respectively. Overall, the model showed moderate discrimination and a high capacity to identify patients at low risk of non-adherence. Conclusion: To our knowledge, GENADHECAR is the first screening instrument with internal validation to identify statin non-adherence using a pharmacokinetic reference method. It offers a brief and practical approach for identifying patients at risk of non-adherence and may help overcome some limitations of conventional self-report methods in this population. Further external validation is needed before routine clinical implementation.

2026-07-31T11:05:30Z Pina López, David Puente Lopez, Esteban López López, Reyes Cascales Martinez, Andrea Fernández Arce, Alejandro López Ros, Paloma García Campos, Jonatan Vázquez Rodríguez, Carolina Pamies Aubalat, Lidia Pascual Rodríguez, Roberto https://hdl.handle.net/11000/40319 2026-08-01T01:03:55Z 2026-07-31T11:04:00Z

Título : Metodología de Revisión Sistemática Simplificada (MRSS) para estudiantes de Grado y Máster Autor : Pina López, David; Puente Lopez, Esteban; López López, Reyes; Cascales Martinez, Andrea; Fernández Arce, Alejandro; López Ros, Paloma; García Campos, Jonatan; Vázquez Rodríguez, Carolina; Pamies Aubalat, Lidia; Pascual Rodríguez, Roberto

2026-07-31T11:04:00Z Badía Hernández, Pedro Valentín Moll Carrió, Joan Díaz Puertas, Rocío Fuentes Baile, María Rodríguez Cañas, Enrique Mira Carrió, Amalia Saceda, Miguel García Morales, Pilar Mallavia Marín, Ricardo https://hdl.handle.net/11000/40316 2026-08-01T01:03:45Z 2026-07-31T08:53:54Z

Título : Desarrollo de nuevos sistemas de liberación de antineoplásicos basados en biopolímeros para el tratamiento de glioblastoma Autor : Badía Hernández, Pedro Valentín; Moll Carrió, Joan; Díaz Puertas, Rocío; Fuentes Baile, María; Rodríguez Cañas, Enrique; Mira Carrió, Amalia; Saceda, Miguel; García Morales, Pilar; Mallavia Marín, Ricardo Resumen : El glioblastoma (GBM) es un tipo de glioma con una baja incidencia, pero una alta tasa de mortalidad debido a su malignidad (1). Los tratamientos actuales del glioblastoma se centran en la cirugía seguida de quimioterapia con fármacos antineoplásicos. Sin embargo, la administración sistémica daña los tejidos no tumorales, por lo que se está investigando su aplicación local y su liberación controlada (2). La síntesis de nanofibras de PMVEMA-Es permitió la encapsulación de BCNU en un 70 % con un tiempo de liberación de 1h, sin modificar sus propiedades sobre la proliferación celular. Se continuará trabajando en su caracterización en modelos celulares 3D.

2026-07-31T08:53:54Z Badía Hernández, Pedro Valentín Moll Carrió, Joan Fuentes Baile, María Mira Carrió, Amalia Díaz Puertas, Rocío García Morales, Pilar Mallavia Marín, Ricardo https://hdl.handle.net/11000/40315 2026-08-01T01:03:53Z 2026-07-31T08:52:57Z

Título : Development of new drug delivery systems based on polymeric nanofibers for glioblastoma treatment Autor : Badía Hernández, Pedro Valentín; Moll Carrió, Joan; Fuentes Baile, María; Mira Carrió, Amalia; Díaz Puertas, Rocío; García Morales, Pilar; Mallavia Marín, Ricardo Resumen : Glioblastoma (GBM) is a type of glioma with a low incidence but a high mortality rate due to its malignancy (1). Current treatments for glioblastoma focus on surgery followed by chemotherapy with antineoplastic drugs. However, systemic administration damages non-tumour tissues, so local application and controlled release is being investigated (2). The synthesis of PMVEMA nanofibers allowed the encapsulation of 100% and 70% of drugs with a release time of 1h, without modifying their properties on cell proliferation. Work will continue with their characterization in 3D cellular models.

2026-07-31T08:52:57Z Badía Hernández, Pedro Valentín https://hdl.handle.net/11000/40314 2026-08-01T01:03:53Z 2026-07-31T08:49:34Z

Título : Photoactive polymeric biomaterials for local combined therapy against glioblastoma Autor : Badía Hernández, Pedro Valentín

2026-07-31T08:49:34Z Badía Hernández, Pedro Valentín https://hdl.handle.net/11000/40313 2026-08-01T01:03:37Z 2026-07-31T08:48:17Z

Título : Desarrollo de nanofibras poliméricas como sistema de liberación de carmustina y doxorrubicina para el tratamiento del glioblastoma Autor : Badía Hernández, Pedro Valentín

2026-07-31T08:48:17Z Díaz Puertas, Rocío Álvarez Martínez, Francisco Javier Badía Hernández, Pedro Valentín Rodríguez Cañas, Enrique Borrás Rocher, Fernando Falcó, Alberto Mallavia Marín, Ricardo https://hdl.handle.net/11000/40312 2026-08-01T01:03:51Z 2026-07-31T08:47:22Z

Título : Optimizing the green synthesis of silver nanoparticles with pomegranate extract for antibacterial purposes: an innovative approach Autor : Díaz Puertas, Rocío; Álvarez Martínez, Francisco Javier; Badía Hernández, Pedro Valentín; Rodríguez Cañas, Enrique; Borrás Rocher, Fernando; Falcó, Alberto; Mallavia Marín, Ricardo Resumen : Silver nanoparticles (AgNPs) have attracted significant attention due to their remarkable antimicrobial and biocidal properties. Green synthesis, which utilizes plant extracts as reducing and stabilizing agents, offers an eco-friendly alternative to traditional methods, reducing toxicity and enhancing biocompatibility. Among natural sources, pomegranate (Punica granatum) peel extract (PGE) is particularly rich in antioxidant compounds such as ellagitannins and polyphenols, which not only facilitate nanoparticle synthesis but also enhance their biological activity. This study focuses on optimizing the green synthesis of AgNPs using PGE through a Box–Behnken response surface methodology (BBD-RSM) to refine key parameters for enhanced reproducibility and efficiency. The synthesized AgNPs were fully characterized, and their antimicrobial properties were evaluated.

2026-07-31T08:47:22Z Díaz-Puertas, Rocío Rodríguez-Cañas, Enrique Fernández-Oliver, Marta Rodríguez, Miguel Badía, Pedro Valentín Falcó, Alberto Mallavia, Ricardo https://hdl.handle.net/11000/40311 2026-08-01T01:03:47Z 2026-07-31T08:42:44Z

Título : Fabrication of PEO electrospun nanofibers loaded with piscidin for antibacterial applications Autor : Díaz-Puertas, Rocío; Rodríguez-Cañas, Enrique; Fernández-Oliver, Marta; Rodríguez, Miguel; Badía, Pedro Valentín; Falcó, Alberto; Mallavia, Ricardo Resumen : The implementation of peptides as therapeutic agents presents some drawbacks. Remarkably, their poor stability hinders their supply and application in biological systems since their amide bonds can be easily proteolyzed by enzymes or hydrolyzed, which leads to short half-lives and their fast removal.

2026-07-31T08:42:44Z Badía, Pedro Valentín Díaz-Puertas, Rocío Rodríguez-Cañas, Enrique Fernández-Oliver, Marta Rodríguez, Miguel Antón, María García, María del Pilar Falcó, Alberto Mallavia, Ricardo https://hdl.handle.net/11000/40310 2026-08-01T01:03:49Z 2026-07-31T08:40:50Z

Título : Elaboración de nanofibras de biopolímeros basadas en quitosano como sistema de liberación de fármacos antineoplásicos en un modelo in vitro de glioblastoma Autor : Badía, Pedro Valentín; Díaz-Puertas, Rocío; Rodríguez-Cañas, Enrique; Fernández-Oliver, Marta; Rodríguez, Miguel; Antón, María; García, María del Pilar; Falcó, Alberto; Mallavia, Ricardo Resumen : Los tumores localizados en cerebro y sistema nervioso central tienen una alta taza de mortalidad Entre estos, el glioblastoma es de los mas agresivo y difíciles de tratar Los tratamientos actuales se basan en procesos de remoción quirúrgica del tumor y un posterior tratamiento con fármacos antineoplásicos, como la temozolamida o la carmustina Sin embargo, el sistema de liberación de estos antineoplásicos es muy general y en dosis no controladas, lo que resulta en efectos secundarios como la muerte de células sanas. Por lo tanto, la búsqueda de nuevos sistemas de entrega de fármacos antineoplásicos es de suma importancia Entre las nuevas estrategias para mejorar los sistemas de liberación de fármacos se encuentran los nanomateriales, que poseen propiedades especificas. Las nanofibras son nanomateriales que permiten que haya una mayor biodisponibilidad de los fármacos y una regulación en su liberación. Al fabricar nanofibras con polímeros biocompatibles como el quitosano, que posee propiedades inmunoestimulantes, antibacterianas, no es tóxico y es biodegradable, se puede establecer un sistema eficiente de liberación de fármacos.

2026-07-31T08:40:50Z Badía Hernández, Pedro Valentín Mira Carrió, Amalia Losada Echeberria, María Díaz Puertas, Rocío Saceda Sánchez, Miguel García Morales, Pilar Mallavia Marín, Ricardo https://hdl.handle.net/11000/40309 2026-08-01T01:03:31Z 2026-07-31T08:40:05Z

Título : Development of post-surgical local delivery systems based on polymeric nanofibers for the administration of antineoplastic drugs against glioblastoma Autor : Badía Hernández, Pedro Valentín; Mira Carrió, Amalia; Losada Echeberria, María; Díaz Puertas, Rocío; Saceda Sánchez, Miguel; García Morales, Pilar; Mallavia Marín, Ricardo Resumen : INTRODUCTION Glioblastoma is an aggressive glioma with low incidence but high mortality, mainly due to its localization and the limited efficacy of current treatments (1). To overcome significant off-target toxicity due to systemic chemotherapy, localized delivery systems with controlled release, such as polymeric carmustine (BCNU) wafers under the name Gliadel®, are being explored (2). Encapsulating chemotherapeutics such as Doxorubicin (DOX) in polymeric nanofibers could offer a promising approach to enhance bioavailability and enable sustained, site-specific delivery. AIM In this work, poly(methyl vinyl ether-alt-maleic anhydride) (PMVEMA) monoethyl ester (Es) and acid (Ac) nanofibers were synthesized as delivery systems for carmustine (BCNU) and doxorubicin (DOX).

2026-07-31T08:40:05Z