https://hdl.handle.net/11000/425 2026-04-07T03:17:28Z 2026-04-07T03:17:28Z JULIBERT, ALICIA Bibiloni, Maria del Mar Bouzas, Cristina Martínez González, Miguel Ángel Salas-Salvadó, Jordi Corella, Dolores Zomeño, Maria Dolors Romaguera, Dora Vioque, Jesus Alonso-Gómez, Ángel Wärnberg, Julia Martínez, J. Alfredo Serra-Majem, Lluis Estruch, Ramon Tinahones, Francisco J https://hdl.handle.net/11000/39167 2026-02-12T02:11:02Z 2026-02-11T12:02:13Z

Título : Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk Autor : JULIBERT, ALICIA; Bibiloni, Maria del Mar; Bouzas, Cristina; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Corella, Dolores; Zomeño, Maria Dolors; Romaguera, Dora; Vioque, Jesus; Alonso-Gómez, Ángel; Wärnberg, Julia; Martínez, J. Alfredo; Serra-Majem, Lluis; Estruch, Ramon; Tinahones, Francisco J Resumen : Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat intake and MetS components in an adult Mediterranean population at high CVD risk. Design: Baseline assessment of nutritional adequacy in participants (n = 6560, men and women, 55-75 years old, with overweight/obesity and MetS) in the PREvención con DIeta MEDiterránea (PREDIMED)-Plus randomized trial. Methods: Assessment of fat intake (total fat, monounsatured fatty acids: MUFA, polyunsaturated fatty acids: PUFA, saturated fatty acids: SFA, trans-fatty acids: trans-FA, linoleic acid, α-linolenic acid, and ω-3 FA) using a validated food frequency questionnaire, and diet quality using 17-item Mediterranean dietary questionnaire and fat quality index (FQI). Results: Participants in the highest quintile of total dietary fat intake showed lower intake of energy, carbohydrates, protein and fiber, but higher intake of PUFA, MUFA, SFA, TFA, LA, ALA and ω-3 FA. Differences in MetS components were found according to fat intake. Odds (5th vs. 1st quintile): hyperglycemia: 1.3-1.6 times higher for total fat, MUFA, SFA and ω-3 FA intake; low high-density lipoprotein cholesterol (HDL-c): 1.2 higher for LA; hypertriglyceridemia: 0.7 lower for SFA and ω-3 FA intake. Conclusions: Dietary fats played different role on MetS components of high CVD risk patients. Dietary fat intake was associated with higher risk of hyperglycemia.

2026-02-11T12:02:13Z Torres-Collado, Laura Garcia de la Hera, Manuela Navarrete-Muñoz, Eva María González Palacios, Sandra Oncina Canovas, Alejandro Vioque, Jesús https://hdl.handle.net/11000/39166 2026-02-12T02:11:03Z 2026-02-11T12:01:38Z

Título : Prevalencia de obesidad de acuerdo a tres índices antropométricos en una muestra representativa de la Comunidad Valenciana Autor : Torres-Collado, Laura; Garcia de la Hera, Manuela; Navarrete-Muñoz, Eva María; González Palacios, Sandra; Oncina Canovas, Alejandro; Vioque, Jesús Resumen : Introducción: La obesidad es un problema de salud pública que afecta y que ha aumentado rápidamente en la última década en un gran número de países en el mundo. Además, es un factor de riesgo importante en la enfermedad cardiovascular y se ha mostrado como un posible factor de riesgo en la mortalidad especialmente por enfermedades crónicas. Objetivo: Determinar la prevalencia de obesidad de acuerdo a tres índices antropométricos como el Índice de Masa Corporal (IMC), la Circunferencia de Cintura (CC) y el porcentaje de Grasa Corporal (% GC) medido por impedancia bioeléctrica y estimar los índices de validez y exactitud para definir obesidad según IMC y CC, usando como referencia el % GC. Material y métodos: Estudio transversal que incluye a 141 participantes de la Encuesta de Nutrición de Comunidad Valenciana realizada en 1994 que fueron evaluados de nuevo 10 años después. Se realizaron mediciones antropométricas usando protocolos estandarizados para peso y talla, obteniendo IMC, CC y % GC. Los puntos de corte utilizados para defin 30 kg/m2, CC > 102 cm en hombres y > 88 cm en mujeres, y un % GC > 27 para hombres y > 40 en mujeres. Se estimaron coeficientes de correlación ajustados por edad entre los distintos indicadores antropométricos. Se estimó la sensibilidad, especificidad y valores predictivos para IMC y CC utilizando % GC como referencia. Resultados: La prevalencia de obesidad fue 19,9% (IMC), 37,6% (CC) y 38,3% (%GC). La correlación osciló entre 0,232 para CC-% GC y 0,829 para IMC-CC. Utilizando el % GC como método de referencia, el IMC mostró mayor especificidad (en mujeres 92,6% y en hombres 93,9%) y la CC mayor sensibilidad (en mujeres 83,3% y en hombres 53,7%) para detectar obesidad. Conclusiones: La prevalencia de obesidad difiere según el indicador antropométrico utilizado. La CC, dada su fácil medición, puede ser el indicador más apropiado a utilizar en estudios de base poblacional y programas preventivos para detectar obesidad en adultos.; Introduction: Obesity is a public health problem that affects and has increased rapidly in the last decade in a large number of countries in the world. Moreover, it is an important cardiovascular risk factor and has been shown to be a possible risk factor in mortality, specially due to chronic disease. Objective: To determine the prevalence of obesity according to three anthropometric indexes: Body Mass Index (BMI), waist circumference (WC) and body fat percentage (% BF) measured by bioelectrical impedance and to estimate the validity and accuracy of BMI and WC indexes to define obesity using % BF as reference method. Material and methods: We carried out a cross-sectional study that included 141 participants from the Nutrition Survey of Comunidad de Valencia conducted in 1994, who were evaluated again 10 years later. Anthropometric measurements were made with standardized protocols for weight and height obtaining BMI, CC and % GC. We classified the participants as obese (yes/no) using the following cut-off points of BMI 30 kg/m2, WC > 102 cm in men and > 88 cm in women, and % BF > 27 for men and 40 in women. Correlation coefficients between anthropometric indexes adjusting by age were obtained. Sensitivity, specificity and predictive values were estimated for BMI and WC using % BF as reference. Results: The prevalence of obesity was 19.9%, 37.6 and 38.3% using BMI, WC and % BF respectively. The correlation coefficients ranged from 0.232 for WC-% BF and 0.829 for BMI-WC. Using the % BF as reference, the BMI showed greater specificity (92,6% in women and 93,9% in men) and WC greater sensitivity (83,3% in women and 53,7% in men) to detect obesity. Conclusions: The prevalence of obesity differs according to the anthropometric index used. WC, given its easy measurement may be the most appropriate indicator to be used in populationbased studies and preventive programs to detect obesity in adults.

2026-02-11T12:01:38Z Galilea-Zabalza, Iñigo Buil-Cosiales, Pilar Salas-Salvadó, Jordi Toledo, Estefanía CAROLINA, ORTEGA-AZORÍN DIEZ-ESPINO, JAVIER Vazquez-Ruiz, Zenaida Zomeño, M. Dolores Vioque, Jesus Martínez, Jose Alfredo Romaguera, Dora Perez-Farinos, Napoleón Lopez Miranda, Jose Estruch, Ramón Bueno Cavanillas, Aurora https://hdl.handle.net/11000/39165 2026-02-12T02:11:03Z 2026-02-11T12:00:51Z

Título : Mediterranean diet and quality of life: Baseline cross-sectional analysis of the PREDIMED-PLUS trial Autor : Galilea-Zabalza, Iñigo; Buil-Cosiales, Pilar; Salas-Salvadó, Jordi; Toledo, Estefanía; CAROLINA, ORTEGA-AZORÍN; DIEZ-ESPINO, JAVIER; Vazquez-Ruiz, Zenaida; Zomeño, M. Dolores; Vioque, Jesus; Martínez, Jose Alfredo; Romaguera, Dora; Perez-Farinos, Napoleón; Lopez Miranda, Jose; Estruch, Ramón; Bueno Cavanillas, Aurora Resumen : We assessed if a 17-item score capturing adherence to a traditional Mediterranean diet (MedDiet) was associated with better health-related quality of life among older Spanish men and women with overweight or obesity harboring the metabolic syndrome. We analyzed baseline data from 6430 men and women (age 55-70 years) participating in the PREDIMED-Plus study. PREDIMED-Plus is a multi-centre randomized trial testing an energy-restricted MedDiet combined with promotion of physical activity and behavioral therapy for primary cardiovascular prevention compared to a MedDiet alone. Participants answered a 36-item questionnaire about health-related quality of life (HRQoL) and a 17-item questionnaire that assessed adherence to an MedDiet. We used ANCOVA and multivariable-adjusted linear regression models to compare baseline adjusted means of the quality of life scales according to categories of adherence to the MedDiet. Higher adherence to the MedDiet was independently associated with significantly better scores in the eight dimensions of HRQoL. Adjusted differences of > = 3 points between the highest and the lowest dietary adherence groups to the MedDiet were observed for vitality, emotional role, and mental health and of > = 2 points for the other dimensions. In conclusion, this study shows a positive association between adherence to a MedDiet and several dimensions of quality of life.

2026-02-11T12:00:51Z Martinez-Gonzalez, Miguel A. Buil-Cosiales, Pilar Corella, Dolores Bulló, Mònica Fitó, Monserrat Vioque, Jesús Romaguera, Dora Martínez, J. Alfredo Wärnberg, Julia López Miranda, Jose Estruch, Ramón Bueno Cavanillas, Aurora Arós, Fernando Tur, Josep Tinahones, Francisco J https://hdl.handle.net/11000/39164 2026-02-12T02:11:01Z 2026-02-11T11:59:56Z

Título : Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial Autor : Martinez-Gonzalez, Miguel A.; Buil-Cosiales, Pilar; Corella, Dolores; Bulló, Mònica; Fitó, Monserrat; Vioque, Jesús; Romaguera, Dora; Martínez, J. Alfredo; Wärnberg, Julia; López Miranda, Jose; Estruch, Ramón; Bueno Cavanillas, Aurora; Arós, Fernando; Tur, Josep; Tinahones, Francisco J

2026-02-11T11:59:56Z Perdiguero-Gil, Enrique Del Cura González, Mercedes https://hdl.handle.net/11000/38720 2025-12-05T02:05:04Z 2025-12-04T08:39:29Z

Título : Historia de la educación, historia de la salud y la enfermedad. ¿Caminos paralelos? Por una historia inter/ multidisciplinar Autor : Perdiguero-Gil, Enrique; Del Cura González, Mercedes

2025-12-04T08:39:29Z Perdiguero-Gil, Enrique https://hdl.handle.net/11000/38719 2025-12-05T02:05:04Z 2025-12-04T08:38:23Z

Título : Pluralidad y ¿ansiedad?: La historia de la medicina hoy Autor : Perdiguero-Gil, Enrique Resumen : Este ensayo reflexiona sobre las tensiones generadas en torno a los estudios históricos sobre la salud y la enfermedad. Tales tensiones tienen variadas aristas y muchas son equiparables a las que aborda la historia de la ciencia. La percepción del riesgo de atomización y pérdida de identidad profesional es importante, pero no parece que la solución sea la vuelta a las grandes narrativas. Otra tensión surge de la aparente lejanía entre la sofisticación de la investigación y la necesidad de dirigirse a públicos diversos entre los que se encuentran estudiantes y profesionales de la salud. Algunos procesos relacionados con el modo en el que se desarrolla y se mide la actividad investigadora están resultando claramente nocivos para la pesquisa histórica. La alternativa que se propone es huir de lo prescriptivo sobre lo que es o debe ser la historia de la medicina e intentar, en el día a día, acercarse de manera rigurosa a lo que supuso enfermar, aliviar, sanar y morir en el pasado, con apertura a nuevos modos de ver y analizar, pero sin perseguir el último «giro» historiográfico. This essay reflects on the tensions generated around historical studies on health and disease. Such tensions have various edges, and many are comparable to those addressed by the History of Science. The perception of the risk of fragmentation and loss of professional identity is important, but it does not seem that the solution is to return to the grand narratives. Another tension arises from the apparent distance between the sophistication of the research and the need to address diverse audiences, including students and health professionals. Some processes related to how research activity is developed and measured are clearly proving to be harmful to historical research. The alternative that is proposed is to escape from the prescriptive analysis of what the History of Medicine is or should be and try, on a daily basis, to apply a rigorous approach to what it meant in the past to get sick, alleviate diseases, heal and die, which is open to new ways of seeing and analyzing, but without pursuing the latest historiographic turn.

2025-12-04T08:38:23Z Perdiguero-Gil, Enrique https://hdl.handle.net/11000/38599 2025-11-29T02:07:31Z 2025-11-28T14:44:35Z

Título : Historia de la Ciencia y Periodismo Científico: una relación necesaria y fructífera Autor : Perdiguero-Gil, Enrique Resumen : El texto muestra la necesidad de una estrecha relación entre el Periodismo Científico y la Historia de la Ciencia. Las noticias científicas publicadas en el pasado son una fuente fundamental para la comprensión histórica de la ciencia. La Historia puede apo11ar al Periodismo Científico la perspectiva necesaria para situar en su contexto lo que acontece en la actualidad. Tomando como punto de pai1ida la pandemia de la Covid-19 se muestra que la historia , más que aportar leccione s, puede ale rtar sobre la complejidad del presente , a la luz de la que se dio en el pasado. Conocer las singulares condiciones sociales, económicas, culturales , políticas y emocionales en las que se desa1rnlla la actividad científica pe1111itee vitar la comparación anacrónica con el pasado y comprender mejor el presente. Los estudios históricos han mostrado las dinámicas que siguen los expe 11os y las controversias mediante las que pretenden zanjar las disputas científicas. Conocer estos procesos ayuda a entender cómo se presentan en la esfera pública las diversas voces expertas que tratan de aportar su saber ante un detem1inado problema . Por último , la Historia de la Ciencia también puede ayudar a situar en perspectiva qué son y cómo se generan las pruebas (evidencias) científicas , tan urgentemente ansiadas en el caso de la Covid-19.

2025-11-28T14:44:35Z Compañ Gabucio, Laura M Torres-Collado, Laura Oncina Canovas, Alejandro Fernández-Tardón, Guillermo Tardon, Adonina Santa-Marina Rodríguez, Loreto Barroeta, Ziortza Vrijheid, Martine Warkentin, Sarah Llop, Sabrina Soler-Blasco, Raquel Ojeda-Belokon, Carolina Garcia de la Hera, Manuela Vioque, Jesús González Palacios, Sandra https://hdl.handle.net/11000/38596 2025-11-29T02:07:34Z 2025-11-28T11:49:55Z

Título : Predictors of ultra-processed foods consumption in 4-year-old Spanish children Autor : Compañ Gabucio, Laura M; Torres-Collado, Laura; Oncina Canovas, Alejandro; Fernández-Tardón, Guillermo; Tardon, Adonina; Santa-Marina Rodríguez, Loreto; Barroeta, Ziortza; Vrijheid, Martine; Warkentin, Sarah; Llop, Sabrina; Soler-Blasco, Raquel; Ojeda-Belokon, Carolina; Garcia de la Hera, Manuela; Vioque, Jesús; González Palacios, Sandra Resumen : Ultra-processed foods (UPF) consumption has increased in recent decades, contributing to poor diet quality and certain health problems in early childhood. This study aimed to evaluate UPF consumption in 4-year-old children and determine maternal and child sociodemographic and lifestyle predictors of UPF consumption. We analysed data for 1736 mother-child pairs from the INfancia y Medio Ambiente birth cohort study. Children's diets were parent-reported using validated food frequency questionnaires from which UPF consumption was calculated according to the NOVA classification. We used multinomial logistic regression to assess associations between sociodemographic and lifestyle characteristics and child UPF consumption in tertiles (low, intermediate, high). The mean (SD) daily UPF consumption was 414.6 (240.2)g/day, accounting for 32.8 % of the total daily intake. The main sources of UPF consumption were ultra-processed dairy products (44.3 %), ultra-processed beverages (17.8 %) and sweet foods (16.5 %). A higher maternal UPF consumption during pregnancy [RRRmedium = 1.68 (95 %CI 1.23-2.30) and RRRhigh = 2.86 (95 %CI: 2.02-4.04)] and child television viewing [RRR>1.5 h/day = 1.65 (95 %CI: 1.21-2.25)] were positively associated with a higher child UPF consumption, whereas maternal age≥30 years was associated with reduced UPF consumption [RRR = 0.71 (95 %CI: 0.54-0.94)]. These associations remained similar when stratified by sex, although maternal age effect was not significant in sex-specific models. Medium and high UPF consumption of mothers during pregnancy, younger age at pregnancy, and more television viewing in children were associated with higher UPF consumption at age 4. The identification of factors associated with child UPF consumption could support the development of health promotion strategies aimed at reducing UPF consumption in children.

2025-11-28T11:49:55Z Ojeda-Belokon, Carolina González Palacios, Sandra Compañ Gabucio, Laura M Oncina Canovas, Alejandro Garcia de la Hera, Manuela Vioque, Jesús Torres-Collado, Laura https://hdl.handle.net/11000/38595 2025-11-29T02:08:16Z 2025-11-28T11:45:57Z

Título : Adherence to Three Mediterranean Dietary Indexes and All-Cause, Cardiovascular, and Cancer Mortality in an Older Mediterranean Population Autor : Ojeda-Belokon, Carolina; González Palacios, Sandra; Compañ Gabucio, Laura M; Oncina Canovas, Alejandro; Garcia de la Hera, Manuela; Vioque, Jesús; Torres-Collado, Laura Resumen : Background/Objectives: A higher adherence to the Mediterranean diet (MedDiet) has been associated with a lower risk of death in different populations, but this association has been insufficiently investigated in the elderly Spanish population. In this study, we assess the association between adherence to three MedDiet indexes and all-cause, cardiovascular disease (CVD), and cancer mortality in a population aged 65 years and older in Spain. Methods: The population included 903 participants from two population-based surveys. Diet was assessed at baseline by using validated food-frequency questionnaires (FFQ). We calculated scores of adherence to the MedDiet for three indexes: alternate Mediterranean Diet Score (aMED), relative Mediterranean Diet Score (rMED) and 17-item energy-restricted Mediterranean Diet Adherence Screener (erMEDAS). Deaths were ascertained through the National Death Index of Spain and the Mortality Registry in the Valencian Region during a 12 year follow-up period. Cox regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI), adjusting for relevant confounders. Results: During the 12 years of follow-up, 403 deaths occurred: 160 due to CVD and 90 to cancer. Compared to participants in the lowest tertile of adherence to aMED, those in the highest tertile showed a 30% lower risk of all-cause mortality, HR = 0.70 (95% CI 0.51–0.96). In addition, per two-point increase in aMED, we observed a 17% lower risk of all-cause mortality, HR = 0.83 (95% CI 0.73–0.95), and a 21% lower risk of CVD mortality, HR = 0.79 (95% CI 0.64–0.99). A 9% lower risk of all-cause mortality was also observed per two-point increase in the rMED score, HR = 0.91 (95% CI 0.84–0.99). Compared to participants in the lowest tertile of adherence to rMED, those in the highest tertile showed evidence of a marginally significant, lower risk of cancer mortality, HR = 0.55 (95% CI 0.29–1.04). No association was observed between the erMEDAS index and mortality for any cause. Conclusions: High adherence to the MedDiet, as measured by aMED and rMED indexes, was associated with lower all-cause, CVD, and cancer mortality in an older Mediterranean population after 12 years of follow-up.

2025-11-28T11:45:57Z Tuells, José Echániz-Martínez, Berta https://hdl.handle.net/11000/38564 2025-11-28T02:05:12Z 2025-11-27T13:50:05Z

Título : Balmis según Humboldt Autor : Tuells, José; Echániz-Martínez, Berta Resumen : La obra del geógrafo y naturalista alemán Alexander von Humboldt, Ensayo político sobre el Reino de la Nueva España (1811), nos permite abordar una revisión de las epidemias de viruelas que afectaron a la población novohispana durante el Setecientos, así como la llegada y desarrollo posterior de la vacuna contra esta enfermedad en aquellos territorios. Por otro lado, desde esa cosmogonía humboldtiana, también se invita a una reflexión sobre la trascendencia de la Real Expedición y la gura de su director, Francisco Balmis, en comparación con la del propio Humboldt y su experiencia en Nueva España.; The work of the German geographer and naturalist Alexander von Humboldt, Political Essay on the Kingdom of New Spain (1811), allows us to undertake a review of smallpox epidemics that affected the population of New Spain during the XVIII century and the arrival and development subsequent vaccine against the disease in those territories. On the other hand, since that humboldtiana cosmogony, it is also invited to re ect on the signi cance of the Royal Expedition and the gure of its director, Francisco Balmis, compared with the Humboldt himself and his experience in New Spain.

2025-11-27T13:50:05Z