DSpace Colección :https://hdl.handle.net/11000/306812026-04-18T19:45:10Z2026-04-18T19:45:10ZCalcium Entry Through Thermosensory ChannelsTABERNER, FRANCISCO JDevesa Giner, IsabelFerrer-Montiel, Antoniohttps://hdl.handle.net/11000/360912025-03-25T02:03:12Z2025-03-24T11:38:07ZTítulo : Calcium Entry Through Thermosensory Channels
Autor : TABERNER, FRANCISCO J; Devesa Giner, Isabel; Ferrer-Montiel, Antonio
Resumen : ThermoTRPs are unique channels that mediate Na + and Ca 2+ currents in
response to changes in ambient temperature. In combination with their activation by
other physical and chemical stimuli, they are considered key integrators of environmental
cues into neuronal excitability. Furthermore, roles of thermoTRPs in nonneuronal
tissues are currently emerging such as insulin secretion in pancreatic
β-cells, and links to cancer. Calcium permeability through thermoTRPs appears a
central hallmark for their physiological and pathological activities. Moreover, it is
currently being proposed that beyond working as a second messenger, Ca 2+ can
function locally by acting on protein complexes near the membrane. Interestingly,
thermoTRPs can enhance and expand the inherent plasticity of signalplexes by conferring
them temperature, pH and lipid regulation through Ca 2+ signalling. Thus,
unveiling the local role of Ca 2+ fl uxes induced by thermoTRPs on the dynamics of
membrane-attached signalling complexes as well as their signifi cance in cellular
processes, are central issues that will expand the opportunities for therapeutic intervention
in disorders involving dysfunction of thermoTRP channels2025-03-24T11:38:07Z