Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31354
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dc.contributor.authorBelda, José I.-
dc.contributor.authorArtola, Alberto-
dc.contributor.authorGarcía Manzanares, María Dolores-
dc.contributor.authorFerrer, Consuelo-
dc.contributor.authorHaroun, Hazem E.-
dc.contributor.authorhassanein, ahmed-
dc.contributor.authorBaeyens, Vincent-
dc.contributor.authorMunoz, Gonzalo-
dc.contributor.authorAlió, Jorge L.-
dc.contributor.otherDepartamentos de la UMH::Producción Vegetal y Microbiologíaes_ES
dc.date.accessioned2024-02-09T10:41:29Z-
dc.date.available2024-02-09T10:41:29Z-
dc.date.created2004-11-
dc.identifier.citationJournal of Cataract and Refractive Surgery, vol. 31 (2005)es_ES
dc.identifier.issn0886-3350-
dc.identifier.issn1873-4502-
dc.identifier.urihttps://hdl.handle.net/11000/31354-
dc.description.abstractPurpose: To evaluate the protective properties of combined sodium hyaluronate2% and mannitol 0.5% (Visiol) on the corneal endothelium in the presence of oxidative stress induced by hydrogen peroxide (H2O2). Setting: Instituto Oftalmolo´ gico de Alicante, Universidad Miguel Herna´ ndez, Alicante, Spain. Methods: This was an exploratory randomized controlled parallel-group, maskedassessor study of 3 sodium hyaluronate-based ophthalmic viscosurgical devices (OVDs): Visiol, Healon (sodium hyaluronate 1%), and Viscoat (sodium hyaluronate 3%–chondroitin sodium 4%). The OVDs were tested for protective effects on the endothelium following oxidative stress induced by H2O2 at increased concentrations: control (lactated Ringer’s solution), 1mM, 10mM, and 100 mM. Groups without OVD were used as controls at the same concentrations of peroxide. Each animal received the same treatment in both eyes (10 eyes per group). Endothelial cell lesion was assessed using the Janus green photometry absorbance technique. Results: At 10 mM peroxide concentration, the value of endothelial cell lesion was significantly lower in the Visiol (16.8%, P Z .0056), Healon (22.2%, P Z .0302), and Viscoat (21.6%, PZ .0336) groups than in the control group (29.4%, no OVD). There was a trend in favor of Visiol to more efficiently reduce cell lesions of the endothelium, than Healon (PZ .055) and Viscoat (P Z .1013). Values of endothelial cell lesion at peroxide concentrations of 1 mM and 100 mM showed the same trends than those observed at 10 mM. Conclusions: All of the OVDs tested efficiently reduced endothelial lesions against free radicals compared with the control group in which no OVD was used. The following sequence for the efficacy of endothelial cell protection was established: Visiol O Viscoat O Healon O no OVD.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent6es_ES
dc.language.isoenges_ES
dc.publisherWilliams & Wilkinses_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleHyaluronic acid combined with mannitol to improve protection against free-radical endothelial damage: Experimental Modeles_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps:// doi.org/10.1016/j.jcrs.2004.11.055es_ES
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