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dc.contributor.authorMoreno-Pérez, Oscar-
dc.contributor.authorEscoín, Corina-
dc.contributor.authorSerna-Candel, Carmen-
dc.contributor.authorPortilla, Joaquín-
dc.contributor.authorBoix, Vicente-
dc.contributor.authorALFAYATE-
dc.contributor.authorGonzález-Sánchez, Victor-
dc.contributor.authorMauri, Montserrat-
dc.contributor.authorSánchez-Payá, José-
dc.contributor.authorPicó , Antonio-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.date.accessioned2024-02-05T11:46:54Z-
dc.date.available2024-02-05T11:46:54Z-
dc.date.created2010-
dc.identifier.citationJournal of Sexual Medicine . 2010 Aug;7(8):2873-83es_ES
dc.identifier.issn1743-6095-
dc.identifier.urihttps://hdl.handle.net/11000/31048-
dc.description.abstractIntroduction: Hypogonadism is common in human immunodeficiency virus (HIV)-infected men; the high concentration of sex hormone binding globulin (SHBG) in this population, induces a "false increase" in total testosterone (TT) values.Aims: To validate the determination of TT and measured free testosterone (FT [radioimmunoassay {RIA}]) for hypogonadism diagnosis in an HIV-infected population using calculated free testosterone (CFT) as reference method; and also to determine the prevalence and identify the risks factors of hypogonadism.Methods: Cross-sectional, observational study. Ninety HIV-infected males (42 ± 8.2 years), not HCV coinfected, antiretroviral therapy (ART)-naive (14 patients), on current ART with enhanced protease inhibitor (PI) (39 patients), or patients on PI-naive ART (NN) (37 patients).Main outcome measures: CFT was calculated by determining TT, SHBG, and albumin (Vermeulen's formula); hypogonadism was defined as CFT <0.22 nmol/L (reference range for young healthy males in our laboratory); sensitivity of TT and FT (RIA) for hypogonadism diagnosis was calculated.Results: Twelve patients (13.3%, 95% confidence interval [CI] 7.8-21.9) by CFT presented hypogonadism. TT and FT (RIA) presented a sensitivity of less than 30% in the diagnosis of hypogonadism. Logistic regression multivariate analysis confirmed an independent association between hypogonadism, the patient's age per decade, odds ratio (OR) 6.9 (CI 1.9-24.8; P = 0.003), and longer duration of HIV infection per decade, OR 13.1 (CI 1.3-130.6; P = 0.02). Hypogonadism was associated with erectile dysfunction.Conclusions: TT and FT (RIA) are not useful in the differential diagnosis of hypogonadism in HIV-infected males. There is a significant prevalence of hypogonadism in HIV-infected males, with the patient's age and duration of the disease being the only identifiable risk factors.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent11es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHypogonadismes_ES
dc.subjectCalculated Free Testosteronees_ES
dc.subjectSHBGes_ES
dc.subjectHIVes_ES
dc.subjectScreeninges_ES
dc.subjectRisk Factorses_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes_ES
dc.titleThe Determination of Total Testosterone and Free Testosterone (RIA) are not Applicable to the Evaluation of Gonadal Function in HIV-Infected Maleses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1111/j.1743-6109.2010.01886.xes_ES
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