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dc.contributor.authorPuente Marín, Sara-
dc.contributor.authorThwaite, Rosemary-
dc.contributor.authorMercado, Luis-
dc.contributor.authorColl, Julio-
dc.contributor.authorRoher, Nerea-
dc.contributor.authorOrtega-Villaizan, María del Mar-
dc.date.accessioned2021-01-25T10:43:31Z-
dc.date.available2021-01-25T10:43:31Z-
dc.date.created2019-04-24-
dc.date.issued2021-01-25-
dc.identifier.issn1664-3224-
dc.identifier.urihttp://hdl.handle.net/11000/7005-
dc.description.abstractFish Red-Blood Cells (RBCs) are nucleated cells that can modulate the expression of different sets of genes in response to stimuli, playing an active role in the homeostasis of the fish immune system. Nowadays, vaccination is one of the main ways to control and prevent viral diseases in aquaculture and the development of novel vaccination approaches is a focal point in fish vaccinology. One of the strategies that has recently emerged is the use of nanostructured recombinant proteins. Nanostructured cytokines have already been shown to immunostimulate and protect fish against bacterial infections. To explore the role of RBCs in the immune response to two nanostructured recombinant proteins, TNFa and a G-VHSV protein fragment, we performed different in vitro and in vivo studies. We show for the first time that rainbow trout RBCs are able to endocytose nanostructured TNFa and G-VHSV protein fragment in vitro, despite not being phagocytic cells, and in response to nanostructured TNFa and G-VHSV fragment, the expression of different immune genes could be modulated.es
dc.description.sponsorshipThis work was supported by the European Research Council fund to MO-V (ERC Starting Grant GA639249)-
dc.description.sponsorshipand by grants from the Spanish Ministry of Science, European commission and AGAUR funds to NR (AGL2015-65129-R MINECO/FEDER-
dc.description.sponsorshipand 2014SGR- 345 AGAUR). RT holds a pre-doctoral scholarship from AGAUR (Spain).-
dc.formatapplication/pdfes
dc.format.extent11es
dc.language.isoenges
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectrythrocyteses
dc.subjectred blood cellses
dc.subjectbacterial inclusion bodieses
dc.subjectTNFaes
dc.subjectVHSV glycoprotein Ges
dc.subjectimmune responsees
dc.subject.other577 - Bioquímica. Biología molecular. Biofísicaes
dc.titleFish Red Blood Cells Modulate Immune Genes in Response to Bacterial Inclusion Bodies Made of TNFa and a G-VHSV Fragmentes
dc.typeinfo:eu-repo/semantics/articlees
dc.contributor.instituteInstituto de Biología Molecular y Celulares
dc.identifier.doi10.3389/fimmu.2019.01055-
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2019.01055-
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