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dc.contributor.authorRuiz Torres, Verónica-
dc.contributor.authorRodríguez Pérez, Celia-
dc.contributor.authorHerranz López, María Dolores-
dc.contributor.authorMartín García, Beatriz-
dc.contributor.authorGómez Caravaca, Ana María-
dc.contributor.authorArráez Román, David-
dc.contributor.authorSegura Carretero, Antonio-
dc.contributor.authorBarrajón Catalán, Enrique-
dc.contributor.authorMicol Molina, Vicente-
dc.contributor.otherDepartamentos de la UMH::Ingenieríaes
dc.date.accessioned2020-03-12T11:12:32Z-
dc.date.available2020-03-12T11:12:32Z-
dc.date.created2019-11-23-
dc.date.issued2020-03-12-
dc.identifier.issn2218-273X-
dc.identifier.urihttp://hdl.handle.net/11000/5851-
dc.description.abstractMarine compounds are a potential source of new anticancer drugs. In this study, the antiproliferative e_ects of 20 invertebrate marine extracts on three colon cancer cell models (HGUE-C-1, HT-29, and SW-480) were evaluated. Extracts from two nudibranchs (Phyllidia varicosa, NA and Dolabella auricularia, NB), a holothurian (Pseudocol ochirus violaceus, PS), and a soft coral (Carotalcyon sp., CR) were selected due to their potent cytotoxic capacities. The four marine extracts exhibited strong antiproliferative e_ects and induced cell cycle arrest at the G2/Mtransition, which evolved into early apoptosis in the case of the CR, NA, and NB extracts and necrotic cell death in the case of the PS extract. All the extracts induced, to some extent, intracellular ROS accumulation, mitochondrial depolarization, caspase activation, and DNA damage. The compositions of the four extracts were fully characterized via HPLC-ESI-TOF-MS analysis, which identified up to 98 compounds. We propose that, among the most abundant compounds identified in each extract, diterpenes, steroids, and sesqui- and seterterpenes (CR); cembranolides (PS); diterpenes, polyketides, and indole terpenes (NA); and porphyrin, drimenyl cyclohexanone, and polar steroids (NB) might be candidates for the observed activity. We postulate that reactive oxygen species (ROS) accumulation is responsible for the subsequent DNA damage, mitochondrial depolarization, and cell cycle arrest, ultimately inducing cell death by either apoptosis or necrosises
dc.description.sponsorshipThis research was funded by projects AGL2015-67995-C3-1-R, AGL2015-67995-C3-2-R AGL2015-67995-C3-3-R, RTI2018-096724-B-C21,-
dc.description.sponsorshipand 2018-096724-B-C22 from the Spanish Ministry of Science, Innovation and Universities;-
dc.description.sponsorshipProject P11-CTS-7625 from Andalusian Regional Government Council of Innovation and Science-
dc.description.sponsorshipprojects PROMETEO/2012/007, PROMETEO/2016/006, and VALi+D fellowship (ACIF/2015/158) from Generalitat Valenciana to VR-Tand CIBER (CB12/03/30038-
dc.formatapplication/pdfen
dc.format.extent37es
dc.language.isoengen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectmarine invertebrateen
dc.subjectsoft coralen
dc.subjectholothurianen
dc.subjectnudibranches
dc.subjectantiproliferativeen
dc.subjectcolon canceren
dc.subjectROSes
dc.subjectDNA damagees
dc.subjectcell cycleen
dc.subjectapoptosises
dc.subjectnecrosises
dc.subjectHPLC-ESI-TOF-MSen
dc.subjectcell deathen
dc.subjectnatural compoundsen
dc.subject.otherFarmacología. Terapéutica. Toxicología. Radiologíaes
dc.titleMarine Invertebrate Extracts Induce Colon Cancer Cell Death via ROS-Mediated DNA Oxidative Damage and Mitochondrial Impairmentes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.3390/biom9120771-
dc.relation.publisherversionhttp://dx.doi.org/10.3390/biom9120771-
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