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|Maestro García-Donas, Beatriz
|Sanz, Jesús M.
|Departamentos de la UMH::Bioquímica y Biología Molecular
|Polyhydroxyalkanoates (PHAs) are natural polyesters of increasing biotechnological importance that are synthesized by many prokaryotic organisms as carbon and energy storage compounds in limiting growth conditions. PHAs accumulate intracellularly in form of inclusion bodies that are covered with a proteinaceous surface layer (granule-associated proteins or GAPs) conforming a network-like surface of structural, metabolic and regulatory polypeptides, and configuring the PHA granules as complex and well-organized subcellular structures that have been designated as ‘carbonosomes’. GAPs include several enzymes related to PHA metabolism (synthases, depolymerases and hydroxylases) together with the so-called phasins, an heterogeneous group of smallsize proteins that cover most of the PHA granule and that are devoid of catalytic functions but nevertheless play an essential role in granule structure and PHA metabolism. Structurally, phasins are amphiphilic proteins that shield the hydrophobic polymer from the cytoplasm. Here, we summarize the characteristics of the different phasins identified so far from PHA producer organisms and highlight the diverse opportunities that they offer in the Biotechnology field.
|This work was supported by grants BIO2013-47684-R
|BIO2016- 79323-R (Spanish Ministry of Economy and Competitiveness
|57 - Biología
|Polyhydroxyalkanoate‐associated phasins as phylogenetically heterogeneous, multipurpose proteins
|Instituto de Biología Molecular y Celular