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Role of the clock gene Rev-erb alpha in metabolism and in the endocrine pancreas


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Title:
Role of the clock gene Rev-erb alpha in metabolism and in the endocrine pancreas
Authors:
Vieira, Elaine
Merino Antolín, Beatriz
Quesada Moll, Iván
Department:
Departamentos de la UMH::Biología Aplicada
Issue Date:
2015-09-01
Abstract:
Several hormones are regulated by circadian rhythms to adjust the metabolism to the light/dark cycles and feeding/activity patterns throughout the day. Circadian rhythms are mainly governed by the central clock located in the suprachiasmatic nucleus but also by clocks present in peripheral organs, like the endocrine pancreas. Plasma glucose levels and the main pancreatic hormones insulin and glucagon also exhibit daily variations. Alterations in circadian rhythms are associated with metabolic disturbances and pathologies such as obesity and diabetes. The molecular components of central and peripheral clocks and their regulatory mechanisms are well established. Among the different clock genes, Rev-erbα is considered one of the key links between circadian rhythms and metabolism. Rev-erbα is a critical part of a negative feedback loop in the core circadian clock and modulates the clock oscillatory properties. In addition, Rev-erbα plays an important role in the regulation of lipid and glucose metabolism, thermogenesis, adipocyte and muscle differentiation as well as mitochondrial function. In the endocrine pancreas, Rev-erbα regulates insulin and glucagon secretion and pancreatic β-cell proliferation. In the present review, we discuss all these subjects and, particularly, the role of the clock gene Rev-erbα in the endocrine pancreas.
Keywords/Subjects:
Rev-erb alpha
clock genes
glucose homeostasis
type 2 diabetes
insulin 21 and glucagon secretion
metabolism
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
Appears in Collections:
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