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dc.contributor.authorCuchillo-Ibañez, Inmaculada-
dc.contributor.authorAndreo-Lillo, Patricia-
dc.contributor.authorPastor-Ferrándiz, Lorena-
dc.contributor.authorCarratalá-Marco, Francisco-
dc.contributor.authorSáez-Valero, Javier-
dc.date.accessioned2024-02-07T10:25:34Z-
dc.date.available2024-02-07T10:25:34Z-
dc.date.created2020-03-30-
dc.identifier.citationFrontiers in Psychiatry. 2020 Mar 30:11:242es_ES
dc.identifier.issn1664-0640-
dc.identifier.urihttps://hdl.handle.net/11000/31212-
dc.description.abstractAutism spectrum disorder (ASD) is a group of neurodevelopmental disorders involving age-dependent gene dysregulation. Reelin is a glycoprotein that varies its expression throughout lifetime and controls cortical patterning and synaptogenesis. Brain and plasma reelin levels have been reported to be low in adults with autism; as well as in children with autism, but only when compared to control adults. Therefore, reelin expression levels in children with autism are unclear. For this reason, we compared plasma reelin levels in children with autism and children without autism (non-ASD) of similar ages to evaluate reelin expression in ASD during childhood. Plasma samples from 19 non-ASD (8.9 ± 0.8 years) and 40 children with autism (7.5 ± 0.5 years) were analyzed. We found that 50% of the children with autism displayed similar plasma reelin levels to the non-ASD group. However, the remaining 50% expressed more than 30 times more reelin compared to non-ASD levels. We also show that male children with autism displayed significantly higher reelin levels than females. The clinical presentation of this subgroup could not be distinguished from that of children with autism. Epilepsy or attention-deficit/hyperactivity disorder (ADHD) was not associated to reelin levels. We conclude that the high levels of plasma reelin might be an important hallmark in a subset of children with autism, previously unnoticed. As we could not find any correlation between reelin levels and ASD clinical presentations, our results may indicate transient reelin increases in the plasma or the characterization of a group of ASD individuals with a different pathophysiology.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent6es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectWestern blottinges_ES
dc.subjectautismes_ES
dc.subjectchildrenes_ES
dc.subjectdimerses_ES
dc.subjectenzyme-linked immunosorbent assayes_ES
dc.subjectoligomerses_ES
dc.subjectreelines_ES
dc.titleElevated Plasma Reelin Levels in Children With Autismes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.contributor.instituteInstitutos de la UMH::Instituto de Neurocienciases_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fpsyt.2020.00242es_ES
Aparece en las colecciones:
Instituto de Neurociencias


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