Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31171
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dc.contributor.authorCompany Devesa, Verónica-
dc.contributor.authorMurcia Ramón, Raquel-
dc.contributor.authorAndreu Cervera, Abraham-
dc.contributor.authorAracil Pastor, Paula-
dc.contributor.authorAlmagro García, Francisca de Paula-
dc.contributor.authorMartínez Pérez, Salvador-
dc.contributor.authorEchevarría Aza, Diego-
dc.contributor.authorde Puelles Martínez de La Torre, Eduardo-
dc.contributor.otherDepartamentos de la UMH::Patología y Cirugíaes_ES
dc.contributor.otherInstituto de Neurocienciases_ES
dc.contributor.otherDepartamentos de la UMH::Histología y Anatomíaes_ES
dc.date.accessioned2024-02-06T17:19:31Z-
dc.date.available2024-02-06T17:19:31Z-
dc.date.created2022-11-
dc.identifier.citationDevelopmental Dynamics 2022 Nov;251(11):1834-1847es_ES
dc.identifier.issn1058-8388-
dc.identifier.issn1097-0177-
dc.identifier.urihttps://hdl.handle.net/11000/31171-
dc.description.abstractBackground: The fasciculus retroflexus is the prominent efferent pathway from the habenular complex. Medial habenular axons form a core packet whereas lateral habenular axons course in a surrounding shell. Both groups of fibers share the same initial pathway but differ in the final segment of the tract, supposedly regulated by surface molecules. The gene Amigo2 codes for a membrane adhesion molecule with an immunoglobulin-like domain 2 and is selectively expressed in the medial habenula. We present it as a candidate for controlling the fasciculation behavior of medial habenula axons. Results: First, we studied the development of the habenular efferents in an Amigo2 lack of function mouse model. The fasciculus retroflexus showed a variable defasciculation phenotype. Gain of function experiments allowed us to generate a more condensed tract and rescued the Amigo2 knock-out phenotype. Changes in Amigo2 function did not alter the course of habenular fibers. Conclusion: We have demonstrated that Amigo2 plays a subtle role in the fasciculation of the fasciculus retroflexuses_ES
dc.formatapplication/pdfes_ES
dc.format.extent14es_ES
dc.language.isoenges_ES
dc.publisherWiley [Commercial Publisher]es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAmigo2es_ES
dc.subjectfasciculationes_ES
dc.subjectfasciculus retroflexuses_ES
dc.subjectlateral habenulaes_ES
dc.subjectmedial habenulaes_ES
dc.titleAdhesion molecule Amigo2 is involved in the fasciculation process of the fasciculus retroflexuses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1002/dvdy.513es_ES
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Artículos Patología y Cirugía


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