Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31169
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dc.contributor.authorCompany Devesa, Verónica-
dc.contributor.authorMoreno Cerdá, Ana-
dc.contributor.authorAndreu Cervera, Abraham-
dc.contributor.authorMurcia Ramón, Raquel-
dc.contributor.authorAlmagro García, Francisca de Paula-
dc.contributor.authorEchevarría Aza, Diego-
dc.contributor.authorMartínez Pérez, Salvador-
dc.contributor.authorde Puelles Martínez de La Torre, Eduardo-
dc.contributor.otherDepartamentos de la UMH::Patología y Cirugíaes_ES
dc.contributor.otherInstituto de Neurocienciases_ES
dc.contributor.otherDepartamentos de la UMH::Histología y Anatomíaes_ES
dc.date.accessioned2024-02-06T17:15:58Z-
dc.date.available2024-02-06T17:15:58Z-
dc.date.created2021-10-
dc.identifier.citationFrontiers in Cell and Developmental Biology 2021 Oct 14:9:755729es_ES
dc.identifier.issn2296-634X-
dc.identifier.urihttps://hdl.handle.net/11000/31169-
dc.description.abstractWnt1 is one of the morphogenes that controls the specification and differentiation of neuronal populations in the developing central nervous system. The habenula is a diencephalic neuronal complex located in the most dorsal aspect of the thalamic prosomere. This diencephalic neuronal population is involved in the limbic system and its malfunction is related with several psychiatric disorders. Our aim is to elucidate the Wnt1 role in the habenula and its main efferent tract, the fasciculus retroflexus, development. In order to achieve these objectives, we analyzed these structures development in a Wnt1 lack of function mouse model. The habenula was generated in our model, but it presented an enlarged volume. This alteration was due to an increment in habenular neuroblasts proliferation rate. The fasciculus retroflexus also presented a wider and disorganized distribution and a disturbed final trajectory toward its target. The mid-hindbrain territories that the tract must cross were miss-differentiated in our model. The specification of the habenula is Wnt1 independent. Nevertheless, it controls its precursors proliferation rate. Wnt1 expressed in the isthmic organizer is vital to induce the midbrain and rostral hindbrain territories. The alteration of these areas is responsible for the fasciculus retroflexus axons misroutees_ES
dc.formatapplication/pdfes_ES
dc.format.extent13es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media [Commercial Publisher]es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectWnt1es_ES
dc.subjectdifferentiationes_ES
dc.subjectfasciculus retroflexuses_ES
dc.subjecthabenulaes_ES
dc.subjectproliferation.es_ES
dc.titleWnt1 Role in the Development of the Habenula and the Fasciculus Retroflexuses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fcell.2021.755729es_ES
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Artículos Patología y Cirugía


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