Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31166
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dc.contributor.authorAdam, Agota Maria-
dc.contributor.authorKemecsei, Robert-
dc.contributor.authorCompany Devesa, Verónica-
dc.contributor.authorMurcia Ramón, Raquel-
dc.contributor.authorJuárez Leal, Iris-
dc.contributor.authorGerecsei, László I-
dc.contributor.authorEchevarría Aza, Diego-
dc.contributor.authorde Puelles Martínez de La Torre, Eduardo-
dc.contributor.authorMartínez Pérez, Salvador-
dc.contributor.authorCsillag, Andras Laszlo-
dc.contributor.otherDepartamentos de la UMH::Patología y Cirugíaes_ES
dc.contributor.otherInstituto de Neurocienciases_ES
dc.contributor.otherDepartamentos de la UMH::Histología y Anatomía / Instituto de Neurocienciases_ES
dc.date.accessioned2024-02-06T17:10:36Z-
dc.date.available2024-02-06T17:10:36Z-
dc.date.created2020-06-
dc.identifier.citationFrontiers in neuroanatomy 2020 Jun 5:14:29es_ES
dc.identifier.issn1662-5129-
dc.identifier.urihttps://hdl.handle.net/11000/31166-
dc.description.abstractGestational exposure to valproic acid (VPA) is known to cause behavioral deficits of sociability, matching similar alterations in human autism spectrum disorder (ASD). Available data are scarce on the neuromorphological changes in VPA-exposed animals. Here, we focused on alterations of the dopaminergic system, which is implicated in motivation and reward, with relevance to social cohesion. Whole brains from 7-day-old mice born to mothers given a single injection of VPA (400 mg/kg b.wt.) on E13.5 were immunostained against tyrosine hydroxylase (TH). They were scanned using the iDISCO method with a laser light-sheet microscope, and the reconstructed images were analyzed in 3D for quantitative morphometry. A marked reduction of mesotelencephalic (MT) axonal fascicles together with a widening of the MT tract were observed in VPA treated mice, while other major brain tracts appeared anatomically intact. We also found a reduction in the abundance of dopaminergic ventral tegmental (VTA) neurons, accompanied by diminished tissue level of DA in ventrobasal telencephalic regions (including the nucleus accumbens (NAc), olfactory tubercle, BST, substantia innominata). Such a reduction of DA was not observed in the non-limbic caudate-putamen. Conversely, the abundance of TH+ cells in the substantia nigra (SN) was increased, presumably due to a compensatory mechanism or to an altered distribution of TH+ neurons occupying the SN and the VTA. The findings suggest that defasciculation of the MT tract and neuronal loss in VTA, followed by diminished dopaminergic input to the ventrobasal telencephalon at a critical time point of embryonic development (E13-E14) may hinder the patterning of certain brain centers underlying decision making and sociabilityes_ES
dc.formatapplication/pdfes_ES
dc.format.extent19es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media [Commercial Publisher]es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectASDes_ES
dc.subjectaxonal growthes_ES
dc.subjectfasciculationes_ES
dc.subjectnigrostriatal pathwayes_ES
dc.subjectventral tegmentumes_ES
dc.titleGestational Exposure to Sodium Valproate Disrupts Fasciculation of the Mesotelencephalic Dopaminergic Tract, With a Selective Reduction of Dopaminergic Output From the Ventral Tegmental Areaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fnana.2020.00029es_ES
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