Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31091

Vitamin D insufficiency and subclinical atherosclerosis in non-diabetic males living with HIV

Title:
Vitamin D insufficiency and subclinical atherosclerosis in non-diabetic males living with HIV
Authors:
Portilla, Joaquin  
Moreno-Pérez, Oscar
Serna-Candel, Carmen  
Escoín, Corina
ALFAYATE
Reus, Sergio  
Merino, Esperanza
Boix, Vicente
Giner, Livia
Sánchez-Payá, José
Picó, Antonio
Editor:
Wiley
Department:
Departamentos de la UMH::Medicina Clínica
Issue Date:
2014
URI:
https://hdl.handle.net/11000/31091
Abstract:
Introduction: Vitamin D insufficiency (VDI) has been associated with increased cardiovascular risk in the non-HIV population. This study evaluates the relationship among serum 25-hydroxyvitamin D [25(OH)D] levels, cardiovascular risk factors, adipokines, antiviral therapy (ART) and subclinical atherosclerosis in HIV-infected males.Methods: A cross-sectional study in ambulatory care was made in non-diabetic patients living with HIV. VDI was defined as 25(OH)D serum levels <75 nmol/L. Fasting lipids, glucose, inflammatory markers (tumour necrosis factor-α, interleukin-6, high-sensitivity C-reactive protein) and endothelial markers (plasminogen activator inhibitor-1, or PAI-I) were measured. The common carotid artery intima-media thickness (C-IMT) was determined. A multivariate logistic regression analysis was made to identify factors associated with the presence of VDI, while multivariate linear regression analysis was used to identify factors associated with common C-IMT.Results: Eighty-nine patients were included (age 42 ± 8 years), 18.9% were in CDC (US Centers for Disease Control and Prevention) stage C and 75 were on ART. VDI was associated with ART exposure, sedentary lifestyle, higher triglycerides levels and PAI-I. In univariate analysis, VDI was associated with greater common C-IMT. The multivariate linear regression model, adjusted by confounding factors, revealed an independent association between common C-IMT and patient age, time of exposure to protease inhibitors (PIs) and impaired fasting glucose (IFG). In contrast, there were no independent associations between common C-IMT and VDI or inflammatory and endothelial markers.Conclusions: VDI was not independently associated with subclinical atherosclerosis in non-diabetic males living with HIV. Older age, a longer exposure to PIs, and IFG were independent factors associated with common C-IMT in this population.
Keywords/Subjects:
HIV
adipokines
antiretroviral treatment
atherosclerosis
carotid intima media thickness
vitamin D insufficiency
Knowledge area:
CDU: Ciencias aplicadas: Medicina: Patología. Medicina clínica. Oncología
Type of document:
application/pdf
Access rights:
info:eu-repo/semantics/openAccess
DOI:
https://doi.org/10.7448/IAS.17.1.18945
Appears in Collections:
Artículos Medicina Clínica



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