Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31068
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dc.contributor.authorMendoza, N.-
dc.contributor.authorQuereda, F.-
dc.contributor.authorPresa, J.-
dc.contributor.authorSalamanca, A.-
dc.contributor.authorSánchez-Borrego, R.-
dc.contributor.authorVázquez, F.-
dc.contributor.authorMartínez Astorquiza, T.-
dc.contributor.otherDepartamentos de la UMH::Salud Pública, Historia de la Ciencia y Ginecologíaes_ES
dc.date.accessioned2024-02-05T12:41:49Z-
dc.date.available2024-02-05T12:41:49Z-
dc.date.created2012-01-04-
dc.identifier.citationClimacteric. 2012 Dec;15(6):587-93es_ES
dc.identifier.issn1473-0804-
dc.identifier.issn1369-7137-
dc.identifier.urihttps://hdl.handle.net/11000/31068-
dc.description.abstractBackground To date, more than 150 candidate genes related to osteoporosis have been described, but osteoporosis has increasingly been considered a polygenic disease modulated by environmental factors. It is thought that osteoporosis predisposition, pathology, and treatment response depend on the interaction between different genes or between genes and environmental factors. Objective The aim of this study was to evaluate the relationship between the presence of single nucleotide polymorphisms (SNPs) in the estrogen metabolic pathway and the development of osteoporosis and to determine whether this relationship is monogenic or whether interactions between genes exist. Materials and methods A multicentric study with 1980 postmenopausal Spanish women in fi ve Spanish communities was conducted. The women completed a specifi c questionnaire that inquired about risk factors for osteoporosis. Data on participants ’ bone mineral density were obtained with dual-energy X-ray densitometers, and genetic data were obtained from frozen peripheral blood. Results The digenic protection combinations indicated involvement of the wild-type genotype (WT) of the 3 UTR marker for the CYP19A1 gene, the IVS4 marker of the same gene, and the BMP15 and FSHR genes. Among patients who carried two or more of the genotypes considered ‘ risky ’ , the triple combination among markers of the ESR2 and NRIP1 genes with any of the two mutations of the analyzed markers of the BMP15 gene gave a mean T -score value of 2.32 0.91 ( p 0.02). Conclusion Variants of the new candidate genes ( NRIP and BMP15 ) can predispose patients to osteoporosis.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent7es_ES
dc.language.isoenges_ES
dc.publisherTaylor and Francises_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectOSTEOPOROSISes_ES
dc.subjectPOLYMORPHISMes_ES
dc.subjectESTROGEN-RELATED GENESes_ES
dc.titleEstrogen-related genes and postmenopausal osteoporosis riskes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.3109/13697137.2012.656160es_ES
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Artículos Salud Pública, Historia de la Ciencia y Ginecología


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