Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/31053
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMoreno-Pérez, Oscar-
dc.contributor.authorBoix, Vicente-
dc.contributor.authorMerino, E-
dc.contributor.authorPicó, A-
dc.contributor.authorReus, S-
dc.contributor.authorALFAYATE-
dc.contributor.authorGiner, L-
dc.contributor.authorMirete, R-
dc.contributor.authorSánchez-Payá, J-
dc.contributor.authorPortilla, J.-
dc.contributor.otherDepartamentos de la UMH::Medicina Clínicaes_ES
dc.date.accessioned2024-02-05T12:15:00Z-
dc.date.available2024-02-05T12:15:00Z-
dc.date.created2015-
dc.identifier.citationHIV Medicine . 2016 Jun;17(6):436-44es_ES
dc.identifier.issn1468-1293-
dc.identifier.urihttps://hdl.handle.net/11000/31053-
dc.description.abstractObjectives: Inhibin B (IB) levels and the IB: follicle-stimulating hormone (FSH) ratio (IFR), biomarkers of global Sertoli cell function, show a strong relationship with male fertility. The aim of the study was to examine the prevalence of impaired fertility potential in HIV-infected men and the influence of antiretroviral therapy (ART) on fertility biomarkers.Methods: A cross-sectional study with sequential sampling was carried out. A total of 169 clinically stable patients in a cohort of HIV-infected men undergoing regular ambulatory assessment in a tertiary hospital were included. The mean [± standard deviation (SD)] age of the patients was 42.6 ± 8.1 years, all were clinically stable, 61.5% had disease classified as Centers for Disease Control and Prevention (CDC) stage A, and were na?ve to ART or had not had any changes to ART for 6 months (91.1%). Morning baseline IB and FSH concentrations were measured using an enzyme-linked immunosorbent assay (ELISA) and an electrochemiluminescent immunoassay (ECLIA), respectively. A multivariate logistic regression model was used to identify factors associated with impaired fertility, defined as IB < 119 pg/mL or IFR < 23.5.Results: The mean (± SD) IB level was 250 ± 103 pg/mL, the median [interquartile range (IQR)] FSH concentration was 5.1 (3.3-7.8) UI/L and the median (IQR) IFR was 46.1 (26.3-83.7). The prevalence of impaired fertility was 21.9% [95% confidence interval (CI) 16.3-20.7%]. Negative correlations of body mass index and waist: hip ratio with FSH and IB levels were observed (P < 0.01), while a sedentary lifestyle and previous nevirapine exposure were associated with a decreased risk of IB levels ≤ 25th percentile in multivariate analysis. Only older age, as a risk factor, and sedentary lifestyle, with a protective effect, were independently associated with impaired fertility in multivariate analysis.Conclusions: Global testicular Sertoli cell function and fertility potential, assessed indirectly through serum IB levels and IB: FSH ratio, appear to be well maintained in HIV-infected men and not damaged by ART.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent9es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHIVes_ES
dc.subjectSertoli celles_ES
dc.subjectantiretroviral treatmentes_ES
dc.subjectfertilityes_ES
dc.subjectinhibin-Bes_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiologíaes_ES
dc.titleBiological markers of fertility (inhibin-B) in HIV-infected men: influence of HIV infection and antiretroviral therapyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttps://doi.org/10.1111/hiv.12350es_ES
Appears in Collections:
Artículos Medicina Clínica


Thumbnail

View/Open:
 Biological markers of fertility (inhibin-B) in HIV-infected.pdf

166,73 kB
Adobe PDF
Share:


Creative Commons ???jsp.display-item.text9???