Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/30961
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dc.contributor.authorMaestro García-Donas, Beatriz-
dc.contributor.authorNovaková, Linda-
dc.contributor.authorHesek, Dusan-
dc.contributor.authorLeyva, Eduardo-
dc.contributor.authorMobashery, Shahriar-
dc.contributor.authorSanz, Jesús M.-
dc.contributor.authorBranny, Pavel-
dc.date.accessioned2024-02-02T09:52:08Z-
dc.date.available2024-02-02T09:52:08Z-
dc.date.created2010-
dc.identifier.citationFEBS Letters . 2011 Jan 21;585(2):357-63es_ES
dc.identifier.issn1873-3468-
dc.identifier.urihttps://hdl.handle.net/11000/30961-
dc.description.abstractThe eukaryotic-type serine/threonine kinase StkP from Streptococcus pneumoniae is an important signal-transduction element that regulates the expression of numerous pneumococcal genes. We have expressed the extracellular C-terminal domain of StkP kinase (C-StkP), elaborated a three-dimensional structural model and performed a spectroscopical characterization of its structure and stability. Biophysical experiments show that C-StkP binds to synthetic samples of the cell wall peptidoglycan (PGN) and to β-lactam antibiotics, which mimic the terminal portions of the PGN stem peptide. This is the first experimental report on the recognition of a minimal PGN unit by a PASTA-containing kinase, suggesting that non-crosslinked PGN may act as a signal for StkP function and pointing to this protein as an interesting target for β-lactam antibiotics.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent9es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleRecognition of peptidoglycan and b-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniaees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.contributor.instituteInstitutos de la UMH::Instituto de Bioingenieríaes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.febslet.2010.12.016es_ES
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