Please use this identifier to cite or link to this item: https://hdl.handle.net/11000/30911
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dc.contributor.authorMontero, David-
dc.contributor.authorWALTHER, Guillaume-
dc.contributor.authorPérez Martín, Antonia-
dc.contributor.authorVicente Salar, Néstor-
dc.contributor.authorRoche, Enrique-
dc.contributor.authorVinet, Agnes-
dc.contributor.otherDepartamentos de la UMH::Biología Aplicadaes_ES
dc.date.accessioned2024-02-01T07:54:12Z-
dc.date.available2024-02-01T07:54:12Z-
dc.date.created2013-07-18-
dc.identifier.citationDiabetologia (2013) 56:2122–2133es_ES
dc.identifier.issn1432-0428-
dc.identifier.issn0012-186X-
dc.identifier.urihttps://hdl.handle.net/11000/30911-
dc.description.abstractAims/hypothesis In type 2 diabetes, in contrast to the well-documented endothelial dysfunction, studies assessing vascular smooth muscle (VSM) function have yielded discrepant results over the last two decades. We therefore sought to determine whether or not VSM function is impaired in individuals with type 2 diabetes. Methods We conducted a systematic search of MEDLINE, Cochrane, Scopus and Web of Science databases, from their respective inceptions until December 2012, for articles evaluating VSM function in individuals with type 2 diabetes. A meta-analysis was performed to compare the standardised mean difference (SMD) in VSM function between individuals with type 2 diabetes and age-matched controls. Subgroup analyses and meta-regression were used to identify sources of heterogeneity. Results Twenty-seven articles (1,042 individuals with type 2 diabetes and 601 control subjects) were included in this analysis. VSM function was significantly impaired in diabetic compared with control subjects (SMD −0.68, 95% CI −0.84, −0.52; p < 0.001). Although moderate heterogeneity among studies was found (I 2 = 52%), no significant publication bias was detected. Subgroup analyses showed a further decline in VSM function assessed in the microcirculation compared with the macrocirculation of individuals with type 2 diabetes (p = 0.009). In meta-regression, VSM function in the microcirculation was inversely associated with BMI and triacylglycerols and was positively associated with HDL-cholesterol. Conclusions/interpretation In addition to the endothelium, the VSM is a source of vascular dysfunction in type 2 diabetes. An exacerbation of VSM function in the microcirculation may be a distinctive feature in type 2 diabetes.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent12es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsinfo:eu-repo/semantics/closedAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMeta-analysises_ES
dc.subjectType 2 diabetes mellituses_ES
dc.subjectVascular smooth muscle functiones_ES
dc.subject.classificationNutrición y bromatologíaes_ES
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biologíaes_ES
dc.titleVascular smooth muscle function in type 2 diabetes mellitus: a systematic review and meta-analysises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1007/s00125-013-2974-1es_ES
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